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    USF1 upstream transcription factor 1 [ Bos taurus (cattle) ]

    Gene ID: 407239, updated on 5-Mar-2024

    Summary

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    Official Symbol
    USF1provided by VGNC
    Official Full Name
    upstream transcription factor 1provided by VGNC
    Primary source
    VGNC:VGNC:55695
    See related
    Ensembl:ENSBTAG00000017873
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 3
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 3 NC_037330.1 (8436862..8442550)

    Chromosome 3 - NC_037330.1Genomic Context describing neighboring genes Neighboring gene nectin cell adhesion molecule 4 Neighboring gene Rho GTPase activating protein 30 Neighboring gene uncharacterized LOC132344818 Neighboring gene thiosulfate sulfurtransferase like domain containing 1 Neighboring gene F11 receptor Neighboring gene small ribosomal subunit protein uS10-like

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037330.1 Chromosome 3 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Requirement of the transcription factor USF1 in bovine oocyte and early embryonic development. Datta TK, et al. Reproduction, 2015 Feb. PMID 25385722, Free PMC Article
    2. Upstream stimulating factors 1 and 2 enhance transcription from the placenta-specific promoter 1.1 of the bovine cyp19 gene. Fürbass R, et al. BMC Mol Biol, 2010 Jan 18. PMID 20082704, Free PMC Article
    3. Molecular characterization and role of bovine upstream stimulatory factor 1 and 2 in the regulation of the prostaglandin G/H synthase-2 promoter in granulosa cells. Sayasith K, et al. J Biol Chem, 2004 Feb 20. PMID 14660559
    4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. study demonstrates that upstream transcription factor 1 (USF1) is a maternally derived transcription factor required for bovine early embryonic development
      Title: Requirement of the transcription factor USF1 in bovine oocyte and early embryonic development.
    2. Depletion of the USFs by RNAi and expression of a dominant-negative USF mutant, were both associated with a significant decrease in P1.1-dependent reporter gene expression.
      Title: Upstream stimulating factors 1 and 2 enhance transcription from the placenta-specific promoter 1.1 of the bovine cyp19 gene.
    3. bovine upstream stimulatory factor 1 and 2 have roles regulating the prostaglandin G/H synthase-2 promoter in granulosa cells [USF1/USF2]
      Title: Molecular characterization and role of bovine upstream stimulatory factor 1 and 2 in the regulation of the prostaglandin G/H synthase-2 promoter in granulosa cells.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC137781

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    upstream stimulatory factor 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001001161.2 → NP_001001161.1  upstream stimulatory factor 1

      See identical proteins and their annotated locations for NP_001001161.1

      Status: PROVISIONAL

      Source sequence(s)
      BC114684
      UniProtKB/Swiss-Prot
      Q6XBT4
      Related
      ENSBTAP00000023760.5, ENSBTAT00000023760.6
      Conserved Domains (1) summary
      cd18924
      Location:196 → 260
      bHLHzip_USF1; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in upstream stimulatory factor 1 (USF1) and similar proteins

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037330.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      8436862..8442550
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024985344.2 → XP_024841112.1  upstream stimulatory factor 1 isoform X1

      UniProtKB/Swiss-Prot
      Q6XBT4
      Conserved Domains (1) summary
      cd18924
      Location:196 → 260
      bHLHzip_USF1; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in upstream stimulatory factor 1 (USF1) and similar proteins

    2. XM_024985356.2 → XP_024841124.1  upstream stimulatory factor 1 isoform X1

      UniProtKB/Swiss-Prot
      Q6XBT4
      Conserved Domains (1) summary
      cd18924
      Location:196 → 260
      bHLHzip_USF1; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in upstream stimulatory factor 1 (USF1) and similar proteins

    3. XM_024985340.2 → XP_024841108.1  upstream stimulatory factor 1 isoform X1

      UniProtKB/Swiss-Prot
      Q6XBT4
      Conserved Domains (1) summary
      cd18924
      Location:196 → 260
      bHLHzip_USF1; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in upstream stimulatory factor 1 (USF1) and similar proteins

    4. XM_024985378.2 → XP_024841146.1  upstream stimulatory factor 1 isoform X3

      Conserved Domains (1) summary
      cd18924
      Location:135 → 199
      bHLHzip_USF1; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in upstream stimulatory factor 1 (USF1) and similar proteins

    5. XM_024985349.2 → XP_024841117.1  upstream stimulatory factor 1 isoform X1

      UniProtKB/Swiss-Prot
      Q6XBT4
      Conserved Domains (1) summary
      cd18924
      Location:196 → 260
      bHLHzip_USF1; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in upstream stimulatory factor 1 (USF1) and similar proteins

    6. XM_024985366.2 → XP_024841134.1  upstream stimulatory factor 1 isoform X2

      Conserved Domains (1) summary
      cd18924
      Location:137 → 201
      bHLHzip_USF1; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in upstream stimulatory factor 1 (USF1) and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6XBT4.1 GenPept UniProtKB/Swiss-Prot:Q6XBT4

    Gene LinkOut

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