klhl21 kelch-like family member 21 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: klhl21provided by ZNC
Official Full Name: kelch-like family member 21provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2627
See related: Ensembl:ENSDARG00000039255 AllianceGenome:ZFIN:ZDB-GENE-040426-2627
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:76933
Summary: Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in chromosome passenger complex localization to spindle midzone; protein ubiquitination; and regulation of cytokinesis. Predicted to act upstream of or within cell division. Predicted to be located in polar microtubule. Predicted to be part of Cul3-RING ubiquitin ligase complex. Orthologous to human KLHL21 (kelch like family member 21). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 23

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	23	NC_007134.7 (24926353..24939148)
105	previous assembly	GRCz10 (GCF_000002035.5)	23	NC_007134.6 (24999809..25012607)

Chromosome 23 - NC_007134.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
contributes_to ubiquitin-protein transferase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
involved_in chromosome passenger complex localization to spindle midzone	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein ubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cytokinesis	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of Cul3-RING ubiquitin ligase complex	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in polar microtubule	ISS Inferred from Sequence or Structural Similarity more info
located_in spindle	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: kelch-like protein 21

Names: kelch-like 21

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001320407.1 → NP_001307336.1 kelch-like protein 21

Status: VALIDATED

Source sequence(s)

CR376748

UniProtKB/Swiss-Prot

Q6NYM1

UniProtKB/TrEMBL

A0A8M9P526

Related

ENSDARP00000121765.1, ENSDART00000137486.3

Conserved Domains (2) summary

sd00038
Location:328 → 370

Kelch; KELCH repeat [structural motif]

cl28614
Location:35 → 549

BTB; Broad-Complex, Tramtrack and Bric a brac

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007134.7 Reference GRCz11 Primary Assembly

Range

24926353..24939148

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005162160.4 → XP_005162217.1 kelch-like protein 21 isoform X1

See identical proteins and their annotated locations for XP_005162217.1

UniProtKB/Swiss-Prot

Q6NYM1

UniProtKB/TrEMBL

A0A8M9P526

Conserved Domains (2) summary

sd00038
Location:328 → 370

Kelch; KELCH repeat [structural motif]

cl28614
Location:35 → 549

BTB; Broad-Complex, Tramtrack and Bric a brac
XM_021469772.1 → XP_021325447.1 kelch-like protein 21 isoform X1

UniProtKB/Swiss-Prot

Q6NYM1

UniProtKB/TrEMBL

A0A8M9P526

Related

ENSDARP00000115156.1, ENSDART00000140335.3

Conserved Domains (2) summary

sd00038
Location:328 → 370

Kelch; KELCH repeat [structural motif]

cl28614
Location:35 → 549

BTB; Broad-Complex, Tramtrack and Bric a brac

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_207081.1: Suppressed sequence

Description

NM_207081.1: This RefSeq was removed because currently there is insufficient support for the transcript.