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    CTLA4 cytotoxic T-lymphocyte associated protein 4 [ Canis lupus familiaris (dog) ]

    Gene ID: 403696, updated on 4-Apr-2024

    Summary

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    Official Symbol
    CTLA4provided by VGNC
    Official Full Name
    cytotoxic T-lymphocyte associated protein 4provided by VGNC
    Primary source
    VGNC:VGNC:59440
    See related
    Ensembl:ENSCAFG00845018252
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Also known as
    CD152
    Orthologs
    human mouse all
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    Genomic context

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    See CTLA4 in Genome Data Viewer
    Location:
    chromosome: 37
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 37 NC_051841.1 (12584278..12590425)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 37 NC_006619.4 (13530863..13537025)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 37 NC_049258.1 (12505745..12511890)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 37 NC_049297.1 (12541354..12547516)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 37 NC_049778.1 (12504724..12510894)

    Chromosome 37 - NC_051841.1Genomic Context describing neighboring genes Neighboring gene CD28 molecule Neighboring gene 60S ribosomal protein L26-like Neighboring gene inducible T cell costimulator Neighboring gene uncharacterized LOC119867940 Neighboring gene uncharacterized LOC119867939

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Gene and protein expression of a soluble form of CTLA-4 in a healthy dog. Tagawa M, et al. J Vet Med Sci, 2017 May 18. PMID 28392507, Free PMC Article
    2. Establishment of long-term tolerance to SRBC in dogs by recombinant canine CTLA4-Ig. Graves SS, et al. Transplantation, 2009 Aug 15. PMID 19667932, Free PMC Article
    3. Increased programmed death ligand (PD-L1) and cytotoxic T-lymphocyte antigen-4 (CTLA-4) expression is associated with metastasis and poor prognosis in malignant canine mammary gland tumours. Ariyarathna H, et al. Vet Immunol Immunopathol, 2020 Dec. PMID 33129194
    4. Cloning and sequencing of dog cDNA encoding the T-cell costimulatory molecule (CTLA-4). Khatlani TS, et al. Immunogenetics, 2000 Jan. PMID 10663567

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Increased programmed death ligand (PD-L1) and cytotoxic T-lymphocyte antigen-4 (CTLA-4) expression is associated with metastasis and poor prognosis in malignant canine mammary gland tumours.
      Title: Increased programmed death ligand (PD-L1) and cytotoxic T-lymphocyte antigen-4 (CTLA-4) expression is associated with metastasis and poor prognosis in malignant canine mammary gland tumours.
    2. Establishment of long-term tolerance to sheep red blood cells in dogs by recombinant canine CTLA4-Ig.
      Title: Establishment of long-term tolerance to SRBC in dogs by recombinant canine CTLA4-Ig.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Process Evidence Code Pubs
    involved_in B cell receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in T cell receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of regulatory T cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of T cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cytotoxic T-lymphocyte protein 4
    Names
    CTLA-4
    costimulatory molecule B7 receptor CD152
    cytotoxic T-lymphocyte antigen 4
    cytotoxic T-lymphocyte-associated antigen 4
    soluble form of cytotoxic T-lymphocyte antigen 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003106.1 → NP_001003106.1  cytotoxic T-lymphocyte protein 4 precursor

      See identical proteins and their annotated locations for NP_001003106.1

      Status: PROVISIONAL

      Source sequence(s)
      AF154843
      UniProtKB/Swiss-Prot
      Q9TT02, Q9XSI1
      UniProtKB/TrEMBL
      A0A8C0QTI4, A0A8C0TW59, F1PUZ6, Q9GKP2
      Related
      ENSCAFP00845025290.1, ENSCAFT00845032352.1
      Conserved Domains (1) summary
      cd05721
      Location:39 → 153
      IgV_CTLA-4; Immunoglobulin Variable (IgV) domain of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4)

    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051841.1 Reference ROS_Cfam_1.0

      Range
      12584278..12590425
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038447290.1 → XP_038303218.1  cytotoxic T-lymphocyte protein 4 isoform X1

      UniProtKB/TrEMBL
      A0A8I3P3L7, A0A8P0PDF5
      Conserved Domains (1) summary
      cd05721
      Location:2 → 116
      IgV_CTLA-4; Immunoglobulin Variable (IgV) domain of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4)

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049297.1 Alternate UMICH_Zoey_3.1

      Range
      12541354..12547516
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049778.1 Alternate UNSW_CanFamBas_1.0

      Range
      12504724..12510894
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049258.1 Alternate UU_Cfam_GSD_1.0

      Range
      12505745..12511890
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006619.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      13530863..13537025
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9XSI1.1 GenPept UniProtKB/Swiss-Prot:Q9XSI1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.