hsd17b1 hydroxysteroid (17-beta) dehydrogenase 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: hsd17b1provided by ZNC
Official Full Name: hydroxysteroid (17-beta) dehydrogenase 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-040901-5
See related: Ensembl:ENSDARG00000027469 AllianceGenome:ZFIN:ZDB-GENE-040901-5
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary: Enables estradiol 17-beta-dehydrogenase activity. Acts upstream of or within androgen metabolic process and estrogen biosynthetic process. Predicted to be located in cytoplasm. Is expressed in brain and gonad. Orthologous to human HSD17B1 (hydroxysteroid 17-beta dehydrogenase 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 3

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (18040324..18047297, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (17889565..17897474, complement)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A role for G143 in zebrafish 17beta-HSD 1 and M146 and M147 in the two zebrafish paralogs prRDH 1 and prRDH 2, respectively, in substrate specificity.
Title: Functional aspects of 17beta-hydroxysteroid dehydrogenase 1 determined by comparison to a closely related retinol dehydrogenase.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables estradiol 17-beta-dehydrogenase [NAD(P)] activity	IBA Inferred from Biological aspect of Ancestor more info
enables estradiol 17-beta-dehydrogenase [NAD(P)] activity	IDA Inferred from Direct Assay more info	PubMed
enables estradiol 17-beta-dehydrogenase [NAD(P)] activity	IEA Inferred from Electronic Annotation more info
enables steroid dehydrogenase activity	IDA Inferred from Direct Assay more info	PubMed
NOT enables testosterone dehydrogenase (NAD+) activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within androgen metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in estrogen biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within estrogen biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within estrogen biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in estrogen biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: estradiol 17-beta-dehydrogenase 1

Names: 17-beta hydroxysteroid dehydrogenase; zf 1.2

XP_021329033.1

EC 1.1.1.62

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_205584.2 → NP_991147.2 estradiol 17-beta-dehydrogenase 1

Status: VALIDATED

Source sequence(s)

CU463849

UniProtKB/TrEMBL

A0A8M9PPS5, F1QUP2

Conserved Domains (1) summary

cl25409
Location:4 → 257

SDR; Short-chain dehydrogenases/reductases (SDR)

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007114.7 Reference GRCz11 Primary Assembly

Range

18040324..18047297 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021473358.1 → XP_021329033.1 estradiol 17-beta-dehydrogenase 1

UniProtKB/TrEMBL

A0A8M9PPS5, F1QUP2

Related

ENSDARP00000026566.6, ENSDART00000020376.8

Conserved Domains (1) summary

cl25409
Location:4 → 257

SDR; Short-chain dehydrogenases/reductases (SDR)