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    LMO7 LIM domain 7 [ Homo sapiens (human) ]

    Gene ID: 4008, updated on 7-Apr-2024

    Summary

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    Official Symbol
    LMO7provided by HGNC
    Official Full Name
    LIM domain 7provided by HGNC
    Primary source
    HGNC:HGNC:6646
    See related
    Ensembl:ENSG00000136153 MIM:604362; AllianceGenome:HGNC:6646
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LOMP; FBX20; LMO7b; FBXO20
    Summary
    This gene encodes a protein containing a calponin homology (CH) domain, a PDZ domain, and a LIM domain, and may be involved in protein-protein interactions. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene, however, the full-length nature of some variants is not known. [provided by RefSeq, Jan 2009]
    Expression
    Broad expression in lung (RPKM 43.5), esophagus (RPKM 32.9) and 17 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    13q22.2
    Exon count:
    40
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (75620434..75859870)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (74844083..75083598)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (76194570..76434006)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7829 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7830 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7831 Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:76123825-76124385 Neighboring gene COMM domain containing 6 Neighboring gene ubiquitin C-terminal hydrolase L3 Neighboring gene ReSE screen-validated silencer GRCh37_chr13:76200739-76200877 Neighboring gene LMO7 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5403 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5404 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5405 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7834 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr13:76259126-76259626 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr13:76259627-76260127 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr13:76279181-76280380 Neighboring gene family with sequence similarity 204 member C, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7835 Neighboring gene NANOG hESC enhancer GRCh37_chr13:76377179-76377853 Neighboring gene NANOG hESC enhancer GRCh37_chr13:76399228-76399729 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5406 Neighboring gene LMO7DN intronic transcript 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr13:76463404-76463962 Neighboring gene LMO7 downstream neighbor Neighboring gene long intergenic non-protein coding RNA 561

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Association of LIM Domain 7 Gene Polymorphisms and Plasma Levels of LIM Domain 7 with Dilated Cardiomyopathy in a Chinese Population. Li C, et al. Appl Biochem Biotechnol, 2017 Jul. PMID 27988857
    2. Analysis of a human cDNA containing a tissue-specific alternatively spliced LIM domain. Putilina T, et al. Biochem Biophys Res Commun, 1998 Nov 18. PMID 9826547
    3. Identification of a Recurrent LMO7-BRAF Fusion in Papillary Thyroid Carcinoma. He H, et al. Thyroid, 2018 Jun. PMID 29768105, Free PMC Article
    4. Circulating exosomal microRNA-96 promotes cell proliferation, migration and drug resistance by targeting LMO7. Wu H, et al. J Cell Mol Med, 2017 Jun. PMID 28026121, Free PMC Article
    5. Knockdown of Lmo7 inhibits chick myogenesis. Possidonio AC, et al. FEBS Lett, 2016 Feb. PMID 26786059

    See all (119) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Novel Long Non-Coding RNA (lncRNA) Transcript AL137782.1 Promotes the Migration of Normal Lung Epithelial Cells through Positively Regulating LMO7.
      Title: Novel Long Non-Coding RNA (lncRNA) Transcript AL137782.1 Promotes the Migration of Normal Lung Epithelial Cells through Positively Regulating LMO7.
    2. New Findings on LMO7 Transcripts, Proteins and Regulatory Regions in Human and Vertebrate Model Organisms and the Intracellular Distribution in Skeletal Muscle Cells.
      Title: New Findings on LMO7 Transcripts, Proteins and Regulatory Regions in Human and Vertebrate Model Organisms and the Intracellular Distribution in Skeletal Muscle Cells.
    3. LMO7 and LIMCH1 co-localized and co-immunoprecipitated.
      Title: LMO7 and LIMCH1 interact with LRIG proteins in lung cancer, with prognostic implications for early-stage disease.
    4. the LMO7-BRAF fusion behaves as an oncogenic alteration in papillary thyroid carcinoma
      Title: Identification of a Recurrent LMO7-BRAF Fusion in Papillary Thyroid Carcinoma.
    5. Data suggest that LMO7 interacts with MAD1 during spindle assembly phase of mitosis; LMO7 plays role in control of mitosis progression and exerts effect on spindle assembly checkpoint; LMO7 colocalizes with actin filaments; LMO7 does not colocalize with MAD1 at kinetochores in prometaphase nor at spindle poles in metaphase. (LMO7 = LIM domain only protein-7; MAD1 = mitotic spindle assembly checkpoint protein MAD1)
      Title: LMO7 exerts an effect on mitosis progression and the spindle assembly checkpoint.
    6. The miR-96-LMO7 axis may be a therapeutic target for lung cancer patients, and new diagnostic or therapeutic strategies could be developed by targeting the miR-96-LMO7 axis.
      Title: Circulating exosomal microRNA-96 promotes cell proliferation, migration and drug resistance by targeting LMO7.
    7. study suggested that the LMO7 gene may play an important role in the pathogenesis of DCM in the Han Chinese population.
      Title: Association of LIM Domain 7 Gene Polymorphisms and Plasma Levels of LIM Domain 7 with Dilated Cardiomyopathy in a Chinese Population.
    8. Data suggest that Lmo7 is localized at the perinuclear region and in fibril-like structures along subsarcolemma of human skeletal myoblasts whereas in human myotubes Lmo7 is found diffuse throughout the cytoplasm.
      Title: Knockdown of Lmo7 inhibits chick myogenesis.
    9. show that LMO7 is upregulated in the stroma of invasive breast carcinoma in a manner that correlates with the increased expression of serum response factor target genes
      Title: LMO7 mediates cell-specific activation of the Rho-myocardin-related transcription factor-serum response factor pathway and plays an important role in breast cancer cell migration.
    10. functional interaction between emerin and Lmo7 is crucial for temporally regulating the expression of key myogenic differentiation genes.
      Title: Emerin inhibits Lmo7 binding to the Pax3 and MyoD promoters and expression of myoblast proliferation genes.
    Submit: New GeneRIF Correction See all GeneRIFs (12)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci.
    EBI GWAS Catalog
    Interrogation of the platelet-derived growth factor receptor alpha locus and corneal astigmatism in Australians of Northern European ancestry: results of a genome-wide association study.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Vpr vpr HIV-1 Vpr upregulates LMO7 in HeLa cells within 12 hours of exposure PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0858

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin-protein transferase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein ubiquitination NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in apical plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in focal adhesion HDA PubMed 
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ubiquitin ligase complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    LIM domain only protein 7
    Names
    F-box only protein 20
    F-box protein Fbx20
    LIM domain only 7 protein
    LMO-7
    zinc-finger domain-containing protein
    NP_001293009.1
    NP_001317512.1
    NP_001353561.1
    NP_001353562.1
    NP_001353563.1
    NP_001353565.1
    NP_005349.3
    NP_056667.2
    XP_011533397.3
    XP_024305127.1
    XP_024305131.2
    XP_047286263.1
    XP_047286264.1
    XP_047286265.1
    XP_047286266.1
    XP_047286267.1
    XP_047286268.1
    XP_047286270.1
    XP_047286271.1
    XP_047286272.1
    XP_047286273.1
    XP_047286274.1
    XP_047286275.1
    XP_047286276.1
    XP_047286277.1
    XP_047286278.1
    XP_047286279.1
    XP_047286280.1
    XP_047286281.1
    XP_047286282.1
    XP_047286283.1
    XP_047286284.1
    XP_047286285.1
    XP_047286286.1
    XP_047286287.1
    XP_047286289.1
    XP_047286290.1
    XP_047286291.1
    XP_047286292.1
    XP_047286293.1
    XP_047286294.1
    XP_047286295.1
    XP_047286296.1
    XP_047286297.1
    XP_047286298.1
    XP_047286299.1
    XP_047286300.1
    XP_047286301.1
    XP_047286302.1
    XP_047286303.1
    XP_047286304.1
    XP_047286305.1
    XP_047286306.1
    XP_047286307.1
    XP_047286308.1
    XP_047286309.1
    XP_054230496.1
    XP_054230497.1
    XP_054230498.1
    XP_054230499.1
    XP_054230500.1
    XP_054230501.1
    XP_054230502.1
    XP_054230503.1
    XP_054230504.1
    XP_054230505.1
    XP_054230506.1
    XP_054230507.1
    XP_054230508.1
    XP_054230509.1
    XP_054230510.1
    XP_054230511.1
    XP_054230512.1
    XP_054230513.1
    XP_054230514.1
    XP_054230515.1
    XP_054230516.1
    XP_054230517.1
    XP_054230518.1
    XP_054230519.1
    XP_054230520.1
    XP_054230521.1
    XP_054230522.1
    XP_054230523.1
    XP_054230524.1
    XP_054230525.1
    XP_054230526.1
    XP_054230527.1
    XP_054230528.1
    XP_054230529.1
    XP_054230530.1
    XP_054230531.1
    XP_054230532.1
    XP_054230533.1
    XP_054230534.1
    XP_054230535.1
    XP_054230536.1
    XP_054230537.1
    XP_054230538.1
    XP_054230539.1
    XP_054230540.1
    XP_054230541.1
    XP_054230542.1
    XP_054230543.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001306080.2 → NP_001293009.1  LIM domain only protein 7 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) is alternatively spliced at the 5' end, and contains two additional internal coding exons, compared to transcript variant 1. The encoded isoform (3) has a distinct N-terminus and is longer than isoform 1.
      Source sequence(s)
      AF144237, AF330045, AL137782, DA313248, FJ711162
      Consensus CDS
      CCDS81773.1
      UniProtKB/TrEMBL
      F8J2B5, F8WD26
      Related
      ENSP00000366757.4, ENST00000377534.8
      Conserved Domains (6) summary
      cd00014
      Location:17 → 129
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00136
      Location:1003 → 1070
      PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
      cd08368
      Location:1562 → 1620
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
      pfam15949
      Location:588 → 734
      DUF4757; Domain of unknown function (DUF4757)
      cd16269
      Location:1218 → 1229
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:1175 → 1231
      GBP_C; Guanylate-binding protein, C-terminal domain

    2. NM_001330583.1 → NP_001317512.1  LIM domain only protein 7 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) represents use of an alternate promoter and therefore differs in the 5' UTR and 5' coding region, compared to variant 1. These differences cause translation initiation at a downstream start codon and result in an isoform (4) with a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AA777749, AF144237, AF330045, AL137782, DA438537, FJ711162
      Consensus CDS
      CCDS81774.1
      UniProtKB/TrEMBL
      A0A8V8TKQ1, E9PMT2
      Related
      ENSP00000317802.8, ENST00000321797.12
      Conserved Domains (5) summary
      cd00136
      Location:770 → 837
      PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
      cd08368
      Location:1329 → 1387
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
      pfam15949
      Location:355 → 501
      DUF4757; Domain of unknown function (DUF4757)
      cd16269
      Location:985 → 996
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:942 → 998
      GBP_C; Guanylate-binding protein, C-terminal domain

    3. NM_001366632.2 → NP_001353561.1  LIM domain only protein 7 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AL137121, AL137782, AL359392
      Consensus CDS
      CCDS53876.1
      UniProtKB/TrEMBL
      A0A0A0MTE2, A0A8V8TKQ1
      Related
      ENSP00000513106.1, ENST00000605961.2
      Conserved Domains (5) summary
      cd00136
      Location:770 → 837
      PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
      cd16269
      Location:985 → 996
      GBP_C; coiled coil [structural motif]
      pfam15949
      Location:355 → 502
      DUF4757; Domain of unknown function (DUF4757)
      cl20817
      Location:942 → 998
      GBP_C; Guanylate-binding protein, C-terminal domain
      cl26511
      Location:943 → 1101
      Neuromodulin_N; Gap junction protein N-terminal region

    4. NM_001366633.2 → NP_001353562.1  LIM domain only protein 7 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AL137121, AL137782, AL359392
      UniProtKB/TrEMBL
      F8J2B5
      Conserved Domains (5) summary
      cd00136
      Location:961 → 1028
      PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
      cd16269
      Location:1176 → 1187
      GBP_C; coiled coil [structural motif]
      pfam15949
      Location:546 → 693
      DUF4757; Domain of unknown function (DUF4757)
      cl20817
      Location:1133 → 1189
      GBP_C; Guanylate-binding protein, C-terminal domain
      cl26511
      Location:1134 → 1292
      Neuromodulin_N; Gap junction protein N-terminal region

    5. NM_001366634.2 → NP_001353563.1  LIM domain only protein 7 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AL137121, AL137782, AL359392
      UniProtKB/TrEMBL
      A0A8V8TKQ1
      Conserved Domains (6) summary
      cd00136
      Location:676 → 743
      PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
      cd08368
      Location:1235 → 1293
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
      cd16269
      Location:891 → 902
      GBP_C; coiled coil [structural motif]
      pfam15949
      Location:261 → 408
      DUF4757; Domain of unknown function (DUF4757)
      cl20817
      Location:848 → 904
      GBP_C; Guanylate-binding protein, C-terminal domain
      cl26511
      Location:849 → 1007
      Neuromodulin_N; Gap junction protein N-terminal region

    6. NM_001366636.2 → NP_001353565.1  LIM domain only protein 7 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AL137121, AL137782, AL359392
      UniProtKB/TrEMBL
      A0A8V8TKQ1
      Conserved Domains (6) summary
      cd00136
      Location:676 → 743
      PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
      cd08368
      Location:1235 → 1293
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
      cd16269
      Location:891 → 902
      GBP_C; coiled coil [structural motif]
      pfam15949
      Location:261 → 408
      DUF4757; Domain of unknown function (DUF4757)
      cl20817
      Location:848 → 904
      GBP_C; Guanylate-binding protein, C-terminal domain
      cl26511
      Location:849 → 1007
      Neuromodulin_N; Gap junction protein N-terminal region

    7. NM_005358.5 → NP_005349.3  LIM domain only protein 7 isoform 1

      See identical proteins and their annotated locations for NP_005349.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AA777749, AB020665, AF330045, AL137244, AW805522, DB064574
      Consensus CDS
      CCDS9454.1
      UniProtKB/TrEMBL
      A0A1P7ZIM8
      Related
      ENSP00000342112.4, ENST00000341547.8
      Conserved Domains (6) summary
      cd00014
      Location:74 → 181
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00136
      Location:721 → 788
      PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
      cd08368
      Location:1280 → 1338
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
      pfam15949
      Location:294 → 452
      DUF4757; Domain of unknown function (DUF4757)
      cd16269
      Location:936 → 947
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:893 → 949
      GBP_C; Guanylate-binding protein, C-terminal domain

    8. NM_015842.2 → NP_056667.2  LIM domain only protein 7 isoform 2

      See identical proteins and their annotated locations for NP_056667.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) is alternatively spliced at the 5' and 3' ends, and contains two additional internal coding exons, compared to transcript variant 1. The encoded isoform (2) has distinct N- and C-termini, and is longer than isoform 1.
      Source sequence(s)
      AA777749, AB020665, AF330045, AK055465, AW805522, DB064574, DB227898
      Consensus CDS
      CCDS53876.1
      UniProtKB/TrEMBL
      A0A0A0MTE2, A0A8V8TKQ1
      Related
      ENSP00000433352.1, ENST00000465261.6
      Conserved Domains (5) summary
      cd00136
      Location:770 → 837
      PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
      cd16269
      Location:985 → 996
      GBP_C; coiled coil [structural motif]
      pfam15949
      Location:355 → 502
      DUF4757; Domain of unknown function (DUF4757)
      cl20817
      Location:942 → 998
      GBP_C; Guanylate-binding protein, C-terminal domain
      cl26511
      Location:943 → 1101
      Neuromodulin_N; Gap junction protein N-terminal region

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

      Range
      75620434..75859870
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047430323.1 → XP_047286279.1  LIM domain only protein 7 isoform X17

    2. XM_047430329.1 → XP_047286285.1  LIM domain only protein 7 isoform X20

    3. XM_047430352.1 → XP_047286308.1  LIM domain only protein 7 isoform X44

    4. XM_047430307.1 → XP_047286263.1  LIM domain only protein 7 isoform X1

    5. XM_047430308.1 → XP_047286264.1  LIM domain only protein 7 isoform X2

    6. XM_047430310.1 → XP_047286266.1  LIM domain only protein 7 isoform X4

    7. XM_047430309.1 → XP_047286265.1  LIM domain only protein 7 isoform X3

    8. XM_047430311.1 → XP_047286267.1  LIM domain only protein 7 isoform X5

    9. XM_047430312.1 → XP_047286268.1  LIM domain only protein 7 isoform X6

    10. XM_047430316.1 → XP_047286272.1  LIM domain only protein 7 isoform X9

    11. XM_047430317.1 → XP_047286273.1  LIM domain only protein 7 isoform X10

      UniProtKB/TrEMBL
      A0A0A0MTE2

    12. XM_047430320.1 → XP_047286276.1  LIM domain only protein 7 isoform X13

    13. XM_024449359.2 → XP_024305127.1  LIM domain only protein 7 isoform X14

      UniProtKB/TrEMBL
      A0A8V8TKQ1
      Conserved Domains (4) summary
      cd00136
      Location:676 → 743
      PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
      cd16269
      Location:918 → 929
      GBP_C; coiled coil [structural motif]
      pfam17380
      Location:878 → 1033
      DUF5401; Family of unknown function (DUF5401)
      cl20817
      Location:875 → 931
      GBP_C; Guanylate-binding protein, C-terminal domain

    14. XM_047430321.1 → XP_047286277.1  LIM domain only protein 7 isoform X15

    15. XM_047430322.1 → XP_047286278.1  LIM domain only protein 7 isoform X16

    16. XM_047430324.1 → XP_047286280.1  LIM domain only protein 7 isoform X18

      Related
      ENSP00000388955.1, ENST00000447038.5

    17. XM_011535095.3 → XP_011533397.3  LIM domain only protein 7 isoform X22

    18. XM_047430333.1 → XP_047286289.1  LIM domain only protein 7 isoform X24

    19. XM_047430334.1 → XP_047286290.1  LIM domain only protein 7 isoform X25

    20. XM_047430331.1 → XP_047286287.1  LIM domain only protein 7 isoform X23

    21. XM_047430337.1 → XP_047286293.1  LIM domain only protein 7 isoform X28

    22. XM_047430338.1 → XP_047286294.1  LIM domain only protein 7 isoform X29

    23. XM_047430330.1 → XP_047286286.1  LIM domain only protein 7 isoform X21

    24. XM_047430335.1 → XP_047286291.1  LIM domain only protein 7 isoform X26

    25. XM_047430336.1 → XP_047286292.1  LIM domain only protein 7 isoform X27

    26. XM_047430340.1 → XP_047286296.1  LIM domain only protein 7 isoform X31

    27. XM_047430343.1 → XP_047286299.1  LIM domain only protein 7 isoform X34

    28. XM_047430315.1 → XP_047286271.1  LIM domain only protein 7 isoform X8

    29. XM_047430319.1 → XP_047286275.1  LIM domain only protein 7 isoform X12

    30. XM_047430341.1 → XP_047286297.1  LIM domain only protein 7 isoform X32

    31. XM_047430345.1 → XP_047286301.1  LIM domain only protein 7 isoform X37

    32. XM_047430347.1 → XP_047286303.1  LIM domain only protein 7 isoform X39

    33. XM_047430350.1 → XP_047286306.1  LIM domain only protein 7 isoform X42

    34. XM_047430344.1 → XP_047286300.1  LIM domain only protein 7 isoform X35

    35. XM_047430327.1 → XP_047286283.1  LIM domain only protein 7 isoform X17

    36. XM_047430326.1 → XP_047286282.1  LIM domain only protein 7 isoform X17

    37. XM_047430353.1 → XP_047286309.1  LIM domain only protein 7 isoform X45

    38. XM_047430314.1 → XP_047286270.1  LIM domain only protein 7 isoform X7

    39. XM_047430318.1 → XP_047286274.1  LIM domain only protein 7 isoform X11

    40. XM_047430325.1 → XP_047286281.1  LIM domain only protein 7 isoform X19

    41. XM_047430339.1 → XP_047286295.1  LIM domain only protein 7 isoform X30

    42. XM_047430342.1 → XP_047286298.1  LIM domain only protein 7 isoform X33

    43. XM_047430346.1 → XP_047286302.1  LIM domain only protein 7 isoform X38

    44. XM_047430348.1 → XP_047286304.1  LIM domain only protein 7 isoform X40

    45. XM_047430351.1 → XP_047286307.1  LIM domain only protein 7 isoform X43

    46. XM_024449363.2 → XP_024305131.2  LIM domain only protein 7 isoform X36

      Related
      ENSP00000431129.1, ENST00000526202.5

    47. XM_047430349.1 → XP_047286305.1  LIM domain only protein 7 isoform X41

    48. XM_047430328.1 → XP_047286284.1  LIM domain only protein 7 isoform X17

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060937.1 Alternate T2T-CHM13v2.0

      Range
      74844083..75083598
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054374537.1 → XP_054230512.1  LIM domain only protein 7 isoform X17

    2. XM_054374543.1 → XP_054230518.1  LIM domain only protein 7 isoform X20

    3. XM_054374567.1 → XP_054230542.1  LIM domain only protein 7 isoform X44

    4. XM_054374521.1 → XP_054230496.1  LIM domain only protein 7 isoform X1

    5. XM_054374522.1 → XP_054230497.1  LIM domain only protein 7 isoform X2

    6. XM_054374524.1 → XP_054230499.1  LIM domain only protein 7 isoform X4

    7. XM_054374523.1 → XP_054230498.1  LIM domain only protein 7 isoform X3

    8. XM_054374525.1 → XP_054230500.1  LIM domain only protein 7 isoform X5

    9. XM_054374526.1 → XP_054230501.1  LIM domain only protein 7 isoform X6

    10. XM_054374529.1 → XP_054230504.1  LIM domain only protein 7 isoform X9

    11. XM_054374530.1 → XP_054230505.1  LIM domain only protein 7 isoform X10

      UniProtKB/TrEMBL
      A0A0A0MTE2

    12. XM_054374533.1 → XP_054230508.1  LIM domain only protein 7 isoform X13

    13. XM_054374534.1 → XP_054230509.1  LIM domain only protein 7 isoform X14

    14. XM_054374535.1 → XP_054230510.1  LIM domain only protein 7 isoform X15

    15. XM_054374536.1 → XP_054230511.1  LIM domain only protein 7 isoform X16

    16. XM_054374538.1 → XP_054230513.1  LIM domain only protein 7 isoform X18

    17. XM_054374545.1 → XP_054230520.1  LIM domain only protein 7 isoform X22

    18. XM_054374547.1 → XP_054230522.1  LIM domain only protein 7 isoform X24

    19. XM_054374548.1 → XP_054230523.1  LIM domain only protein 7 isoform X25

    20. XM_054374546.1 → XP_054230521.1  LIM domain only protein 7 isoform X23

    21. XM_054374551.1 → XP_054230526.1  LIM domain only protein 7 isoform X28

    22. XM_054374552.1 → XP_054230527.1  LIM domain only protein 7 isoform X29

    23. XM_054374544.1 → XP_054230519.1  LIM domain only protein 7 isoform X21

    24. XM_054374549.1 → XP_054230524.1  LIM domain only protein 7 isoform X26

    25. XM_054374550.1 → XP_054230525.1  LIM domain only protein 7 isoform X27

    26. XM_054374554.1 → XP_054230529.1  LIM domain only protein 7 isoform X31

    27. XM_054374557.1 → XP_054230532.1  LIM domain only protein 7 isoform X34

    28. XM_054374528.1 → XP_054230503.1  LIM domain only protein 7 isoform X8

    29. XM_054374532.1 → XP_054230507.1  LIM domain only protein 7 isoform X12

    30. XM_054374555.1 → XP_054230530.1  LIM domain only protein 7 isoform X32

    31. XM_054374560.1 → XP_054230535.1  LIM domain only protein 7 isoform X37

    32. XM_054374562.1 → XP_054230537.1  LIM domain only protein 7 isoform X39

    33. XM_054374565.1 → XP_054230540.1  LIM domain only protein 7 isoform X42

    34. XM_054374558.1 → XP_054230533.1  LIM domain only protein 7 isoform X35

    35. XM_054374541.1 → XP_054230516.1  LIM domain only protein 7 isoform X17

    36. XM_054374540.1 → XP_054230515.1  LIM domain only protein 7 isoform X17

    37. XM_054374564.1 → XP_054230539.1  LIM domain only protein 7 isoform X41

    38. XM_054374527.1 → XP_054230502.1  LIM domain only protein 7 isoform X7

    39. XM_054374568.1 → XP_054230543.1  LIM domain only protein 7 isoform X45

    40. XM_054374531.1 → XP_054230506.1  LIM domain only protein 7 isoform X11

    41. XM_054374539.1 → XP_054230514.1  LIM domain only protein 7 isoform X19

    42. XM_054374553.1 → XP_054230528.1  LIM domain only protein 7 isoform X30

    43. XM_054374556.1 → XP_054230531.1  LIM domain only protein 7 isoform X33

    44. XM_054374561.1 → XP_054230536.1  LIM domain only protein 7 isoform X38

    45. XM_054374563.1 → XP_054230538.1  LIM domain only protein 7 isoform X40

    46. XM_054374566.1 → XP_054230541.1  LIM domain only protein 7 isoform X43

    47. XM_054374559.1 → XP_054230534.1  LIM domain only protein 7 isoform X36

    48. XM_054374542.1 → XP_054230517.1  LIM domain only protein 7 isoform X17

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_015843.1: Suppressed sequence

      Description
      NM_015843.1: This RefSeq was temporarily suppressed because the CDS is 5'' partial, and currently there is not sufficient data to support this transcript variant.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8WWI1.3 GenPept UniProtKB/Swiss-Prot:Q8WWI1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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