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    Thoc6 THO complex 6 [ Mus musculus (house mouse) ]

    Gene ID: 386612, updated on 19-Mar-2024

    Summary

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    Official Symbol
    Thoc6provided by MGI
    Official Full Name
    THO complex 6provided by MGI
    Primary source
    MGI:MGI:2677480
    See related
    Ensembl:ENSMUSG00000041319 AllianceGenome:MGI:2677480
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Wdr58; F830014G06Rik
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in several processes, including mRNA export from nucleus; negative regulation of apoptotic process; and viral mRNA export from host cell nucleus. Predicted to act upstream of or within RNA processing; apoptotic process; and mRNA transport. Predicted to be located in nuclear speck. Predicted to be part of THO complex part of transcription export complex. Predicted to colocalize with chromosome, telomeric region. Orthologous to human THOC6 (THO complex 6). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in thymus adult (RPKM 19.7), CNS E11.5 (RPKM 13.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    17 A3.3; 17 11.97 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (23887592..23892891, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (23668618..23673917, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene calcium binding protein 39-like pseudogene Neighboring gene matrix metallopeptidase 25 Neighboring gene ribosomal protein L36 pseudogene Neighboring gene BICD family like cargo adaptor 2 Neighboring gene STARR-positive B cell enhancer ABC_E8656 Neighboring gene host cell factor C1 regulator 1 (XPO1-dependent) Neighboring gene tumor necrosis factor receptor superfamily, member 12a Neighboring gene claudin 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The THO complex regulates pluripotency gene mRNA export and controls embryonic stem cell self-renewal and somatic cell reprogramming. Wang L, et al. Cell Stem Cell, 2013 Dec 5. PMID 24315442, Free PMC Article
    2. Proteomics analysis of Ring1B/Rnf2 interactors identifies a novel complex with the Fbxl10/Jhdm1B histone demethylase and the Bcl6 interacting corepressor. Sánchez C, et al. Mol Cell Proteomics, 2007 May. PMID 17296600
    3. Analysis of early nephron patterning reveals a role for distal RV proliferation in fusion to the ureteric tip via a cap mesenchyme-derived connecting segment. Georgas K, et al. Dev Biol, 2009 Aug 15. PMID 19501082
    4. ATG5 is required for B cell polarization and presentation of particulate antigens. Arbogast F, et al. Autophagy, 2019 Feb. PMID 30196744, Free PMC Article
    5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC107304, MGC109691

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in central nervous system development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA export from nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within mRNA transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of THO complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of THO complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of THO complex part of transcription export complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    colocalizes_with chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription export complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription export complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    THO complex subunit 6 homolog
    Names
    WD repeat domain 58
    WD repeat-containing protein 58

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008425.2 → NP_001008425.1  THO complex subunit 6 homolog

      See identical proteins and their annotated locations for NP_001008425.1

      Status: VALIDATED

      Source sequence(s)
      AC154766, AI850888, BC085131, CX224561
      Consensus CDS
      CCDS28454.1
      UniProtKB/Swiss-Prot
      Q5U4D9
      UniProtKB/TrEMBL
      D3Z132
      Related
      ENSMUSP00000038137.5, ENSMUST00000047436.11
      Conserved Domains (2) summary
      sd00039
      Location:28 → 74
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:31 → 196
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. NM_001357380.1 → NP_001344309.1  THO complex subunit 6 homolog

      Status: VALIDATED

      Source sequence(s)
      AC154766, AI850888, BC085131, CO428739
      Consensus CDS
      CCDS28454.1
      UniProtKB/Swiss-Prot
      Q5U4D9
      UniProtKB/TrEMBL
      D3Z132
      Related
      ENSMUSP00000093239.5, ENSMUST00000095579.11
      Conserved Domains (2) summary
      sd00039
      Location:28 → 74
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:31 → 196
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      23887592..23892891 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030249886.1 → XP_030105746.1  THO complex subunit 6 homolog isoform X1

      UniProtKB/Swiss-Prot
      Q5U4D9
      UniProtKB/TrEMBL
      D3Z132
      Related
      ENSMUSP00000111153.3, ENSMUST00000115490.9
      Conserved Domains (2) summary
      sd00039
      Location:28 → 74
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:31 → 196
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5U4D9.1 GenPept UniProtKB/Swiss-Prot:Q5U4D9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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