Trim55 tripartite motif-containing 55 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Trim55provided by MGI
Official Full Name: tripartite motif-containing 55provided by MGI
Primary source: MGI:MGI:3036269
See related: Ensembl:ENSMUSG00000060913 AllianceGenome:MGI:3036269
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Murf2; Rnf29; MuRF-2; D830041C10Rik
Summary: Predicted to enable identical protein binding activity and ubiquitin protein ligase activity. Acts upstream of or within with a positive effect on diapedesis and leukocyte migration involved in inflammatory response. Acts upstream of or within with a negative effect on macrophage migration. Predicted to be active in cytoplasm. Is expressed in cardiac muscle tissue; heart; heart left ventricle; and left atrium. Orthologous to human TRIM55 (tripartite motif containing 55). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in heart adult (RPKM 18.9), limb E14.5 (RPKM 5.3) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 A2; 3 5.65 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (19698591..19746748)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (19644344..19692584)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TRIM55 promotes noncanonical NF-kappaB signaling and B cell-mediated immune responses by coordinating p100 ubiquitination and processing.
Title: TRIM55 promotes noncanonical NF-κB signaling and B cell-mediated immune responses by coordinating p100 ubiquitination and processing.
Expression of MuRF1 or MuRF2 is essential for the induction of skeletal muscle atrophy and dysfunction in a murine pulmonary hypertension model.
Title: Expression of MuRF1 or MuRF2 is essential for the induction of skeletal muscle atrophy and dysfunction in a murine pulmonary hypertension model.
MuRF2 regulates PPARgamma1 activity to protect against diabetic cardiomyopathy and enhance weight gain induced by a high fat diet.
Title: MuRF2 regulates PPARγ1 activity to protect against diabetic cardiomyopathy and enhance weight gain induced by a high fat diet.
MuRF1 and MuRF2 play a redundant role in regulating developmental physiologic hypertrophy, by regulating E2F transcription factors essential for normal cardiac development and by supporting E2F localization to the nucleus, but not through degradation.
Title: Muscle ring finger 1 and muscle ring finger 2 are necessary but functionally redundant during developmental cardiac growth and regulate E2F1-mediated gene expression in vivo.
results indicate that MURF2A and MURF2B proteins could participate in the molecular switch between the two ubiquitin degradative pathways.
Title: MURF2B, a novel LC3-binding protein, participates with MURF2A in the switch between autophagy and ubiquitin proteasome system during differentiation of C2C12 muscle cells.
MURF2 isoforms undergo pre- and postnatal switching and overall downregulation in developing skeletal muscle.
Title: Developmental regulation of MURF E3 ubiquitin ligases in skeletal muscle.
MURF2 expression parallels that of the autophagy-associated proteins LC3, p62/SQSTM1 and nbr1
Title: Developmental regulation of MURF ubiquitin ligases and autophagy proteins nbr1, p62/SQSTM1 and LC3 during cardiac myofibril assembly and turnover.
Data suggest that expression of MuRF1 is required for remodeling of type-II fibers under pathophysiological stress states, whereas MuRF1 and MuRF2 together are required for maintenance of type-II fibers, possibly via the regulation of myozenin-1.
Title: MuRF1 is a muscle fiber-type II associated factor and together with MuRF2 regulates type-II fiber trophicity and maintenance.
Double knockout (dKO) mice obtained by the inactivation of all four MuRF1 and MuRF2 alleles developed extreme cardiac and milder skeletal muscle hypertrophy.
Title: Cooperative control of striated muscle mass and metabolism by MuRF1 and MuRF2.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D3Mit91 (e-PCR), detects polymorphism
- UniSTS:129862

Trim55 (e-PCR), detects polymorphism
- UniSTS:536426

Trim55 (e-PCR), detects polymorphism
- UniSTS:536443

Trim55 (e-PCR), detects polymorphism
- UniSTS:536449

Trim55 (e-PCR), detects polymorphism
- UniSTS:536450

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables protein-macromolecule adaptor activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within_positive_effect diapedesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within_negative_effect interleukin-6 production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within_positive_effect leukocyte migration involved in inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within_negative_effect macrophage cytokine production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within_negative_effect macrophage migration	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of non-canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in protein K48-linked ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: tripartite motif-containing 55; tripartite motif-containing protein 55

Names: muscle-specific RING finger protein 2; ring finger protein 29

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081281.2 → NP_001074750.1 tripartite motif-containing 55

See identical proteins and their annotated locations for NP_001074750.1

Status: VALIDATED

Source sequence(s)

AC141209

Consensus CDS

CCDS38399.1

UniProtKB/Swiss-Prot

G3X8Y1, Q8C6Y1

Related

ENSMUSP00000029139.8, ENSMUST00000029139.9

Conserved Domains (3) summary

cd00162
Location:26 → 85

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

pfam00643
Location:120 → 161

zf-B_box; B-box zinc finger

cl23765
Location:168 → 294

iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

19698591..19746748

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006535489.5 → XP_006535552.1 tripartite motif-containing protein 55 isoform X1

Conserved Domains (4) summary

smart00502
Location:168 → 294

BBC; B-Box C-terminal domain

cd16760
Location:21 → 84

RING-HC_MuRF2; RING finger, HC subclass, found in muscle-specific RING finger protein 2 (MuRF-2) and similar proteins

pfam05466
Location:360 → 502

BASP1; Brain acid soluble protein 1 (BASP1 protein)

cd19832
Location:122 → 166

Bbox2_MuRF2_C-II; B-box-type 2 zinc finger found in muscle-specific RING finger protein 2 (MuRF-2) and similar proteins
XM_006535490.4 → XP_006535553.1 tripartite motif-containing protein 55 isoform X2

Conserved Domains (3) summary

smart00502
Location:168 → 294

BBC; B-Box C-terminal domain

cd16760
Location:21 → 84

RING-HC_MuRF2; RING finger, HC subclass, found in muscle-specific RING finger protein 2 (MuRF-2) and similar proteins

cd19832
Location:122 → 166

Bbox2_MuRF2_C-II; B-box-type 2 zinc finger found in muscle-specific RING finger protein 2 (MuRF-2) and similar proteins