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    PAFAH1B1 platelet activating factor acetylhydrolase 1b regulatory subunit 1 [ Gallus gallus (chicken) ]

    Gene ID: 374224, updated on 3-Apr-2024

    Summary

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    Official Symbol
    PAFAH1B1provided by CGNC
    Official Full Name
    platelet activating factor acetylhydrolase 1b regulatory subunit 1provided by CGNC
    Primary source
    CGNC:4356
    See related
    Ensembl:ENSGALG00010029593
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    LIS1
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 19
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 19 NC_052550.1 (9923300..9952429)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 19 NC_052591.1 (9660934..9690066)

    Chromosome 19 - NC_052550.1Genomic Context describing neighboring genes Neighboring gene translation initiation factor IF-2-like Neighboring gene microRNA 1592 Neighboring gene MAX network transcriptional repressor Neighboring gene microRNA 1689 Neighboring gene clustered mitochondria homolog Neighboring gene spidroin-1-like Neighboring gene coiled-coil domain containing 92B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expression of chLIS1, a chicken homolog of LIS1. Shmueli O, et al. Dev Genes Evol, 2000 Jan. PMID 10603088
    2. Cytoplasmic dynein and LIS1 are required for microtubule advance during growth cone remodeling and fast axonal outgrowth. Grabham PW, et al. J Neurosci, 2007 May 23. PMID 17522326, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LIS1/PAFAH1B1 plays a prominent role in microtubule advance during growth cone remodeling associated with axonogenesis.
      Title: Cytoplasmic dynein and LIS1 are required for microtubule advance during growth cone remodeling and fast axonal outgrowth.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in intra-Golgi vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of COPI vesicle coat IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    lissencephaly-1 homolog
    Names
    LIS-1
    PAF acetylhydrolase 45 kDa subunit
    PAF-AH 45 kDa subunit
    PAF-AH alpha
    PAFAH alpha
    chLIS1
    platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
    platelet-activating factor acetylhydrolase IB subunit alpha
    NP_989655.1
    XP_015151145.1
    XP_015151146.1
    XP_015151147.1
    XP_024997649.1
    XP_040505935.1
    XP_040505936.1
    XP_040505937.1
    XP_040505939.1
    XP_040505940.1
    XP_040505941.1
    XP_040505942.1
    XP_046758238.1
    XP_046758239.1
    XP_046758240.1
    XP_046758241.1
    XP_046758242.1
    XP_046785830.1
    XP_046785831.1
    XP_046785833.1
    XP_046785834.1
    XP_046785835.1
    XP_046785836.1
    XP_046785837.1
    XP_046785838.1
    XP_046785839.1
    XP_046785840.1
    XP_046785841.1
    XP_046785842.1
    XP_046785844.1
    XP_046785845.1
    XP_046785846.1
    XP_046785847.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_204324.2 → NP_989655.1  lissencephaly-1 homolog

      See identical proteins and their annotated locations for NP_989655.1

      Status: PROVISIONAL

      Source sequence(s)
      JAENSK010000323
      UniProtKB/Swiss-Prot
      Q9PTR5
      UniProtKB/TrEMBL
      A0A8V1AJB6
      Conserved Domains (3) summary
      smart00667
      Location:7 → 39
      LisH; Lissencephaly type-1-like homology motif
      cd00200
      Location:104 → 408
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:111 → 148
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052550.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      9923300..9952429
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015295661.4 → XP_015151147.1  lissencephaly-1 homolog isoform X1

      UniProtKB/Swiss-Prot
      Q9PTR5
      UniProtKB/TrEMBL
      A0A8V1AJB6
      Conserved Domains (3) summary
      smart00667
      Location:7 → 39
      LisH; Lissencephaly type-1-like homology motif
      cd00200
      Location:104 → 408
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:111 → 148
      7WD40; WD40 repeat [structural motif]

    2. XM_040650001.2 → XP_040505935.1  lissencephaly-1 homolog isoform X1

      UniProtKB/Swiss-Prot
      Q9PTR5
      UniProtKB/TrEMBL
      A0A8V1AJB6
      Conserved Domains (3) summary
      smart00667
      Location:7 → 39
      LisH; Lissencephaly type-1-like homology motif
      cd00200
      Location:104 → 408
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:111 → 148
      7WD40; WD40 repeat [structural motif]

    3. XM_040650002.2 → XP_040505936.1  lissencephaly-1 homolog isoform X1

      UniProtKB/Swiss-Prot
      Q9PTR5
      UniProtKB/TrEMBL
      A0A8V1AJB6
      Conserved Domains (3) summary
      smart00667
      Location:7 → 39
      LisH; Lissencephaly type-1-like homology motif
      cd00200
      Location:104 → 408
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:111 → 148
      7WD40; WD40 repeat [structural motif]

    4. XM_046902283.1 → XP_046758239.1  lissencephaly-1 homolog isoform X1

      UniProtKB/Swiss-Prot
      Q9PTR5

    5. XM_015295660.3 → XP_015151146.1  lissencephaly-1 homolog isoform X1

      UniProtKB/Swiss-Prot
      Q9PTR5
      UniProtKB/TrEMBL
      A0A8V1AJB6
      Related
      ENSGALP00010044227.1, ENSGALT00010071537.1
      Conserved Domains (3) summary
      smart00667
      Location:7 → 39
      LisH; Lissencephaly type-1-like homology motif
      cd00200
      Location:104 → 408
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:111 → 148
      7WD40; WD40 repeat [structural motif]

    6. XM_015295659.4 → XP_015151145.1  lissencephaly-1 homolog isoform X1

      UniProtKB/Swiss-Prot
      Q9PTR5
      UniProtKB/TrEMBL
      A0A8V1AJB6
      Related
      ENSGALP00010044228.1, ENSGALT00010071538.1
      Conserved Domains (3) summary
      smart00667
      Location:7 → 39
      LisH; Lissencephaly type-1-like homology motif
      cd00200
      Location:104 → 408
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:111 → 148
      7WD40; WD40 repeat [structural motif]

    7. XM_046902282.1 → XP_046758238.1  lissencephaly-1 homolog isoform X1

      UniProtKB/Swiss-Prot
      Q9PTR5

    8. XM_040650005.2 → XP_040505939.1  lissencephaly-1 homolog isoform X1

      UniProtKB/Swiss-Prot
      Q9PTR5
      UniProtKB/TrEMBL
      A0A8V1AJB6
      Conserved Domains (3) summary
      smart00667
      Location:7 → 39
      LisH; Lissencephaly type-1-like homology motif
      cd00200
      Location:104 → 408
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:111 → 148
      7WD40; WD40 repeat [structural motif]

    9. XM_046902286.1 → XP_046758242.1  lissencephaly-1 homolog isoform X1

      UniProtKB/Swiss-Prot
      Q9PTR5

    10. XM_040650003.2 → XP_040505937.1  lissencephaly-1 homolog isoform X1

      UniProtKB/Swiss-Prot
      Q9PTR5
      UniProtKB/TrEMBL
      A0A8V1AJB6
      Conserved Domains (3) summary
      smart00667
      Location:7 → 39
      LisH; Lissencephaly type-1-like homology motif
      cd00200
      Location:104 → 408
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:111 → 148
      7WD40; WD40 repeat [structural motif]

    11. XM_040650006.2 → XP_040505940.1  lissencephaly-1 homolog isoform X1

      UniProtKB/Swiss-Prot
      Q9PTR5
      UniProtKB/TrEMBL
      A0A8V1AJB6
      Conserved Domains (3) summary
      smart00667
      Location:7 → 39
      LisH; Lissencephaly type-1-like homology motif
      cd00200
      Location:104 → 408
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:111 → 148
      7WD40; WD40 repeat [structural motif]

    12. XM_040650008.2 → XP_040505942.1  lissencephaly-1 homolog isoform X1

      UniProtKB/Swiss-Prot
      Q9PTR5
      UniProtKB/TrEMBL
      A0A8V1AJB6
      Conserved Domains (3) summary
      smart00667
      Location:7 → 39
      LisH; Lissencephaly type-1-like homology motif
      cd00200
      Location:104 → 408
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:111 → 148
      7WD40; WD40 repeat [structural motif]

    13. XM_046902284.1 → XP_046758240.1  lissencephaly-1 homolog isoform X1

      UniProtKB/Swiss-Prot
      Q9PTR5

    14. XM_040650007.2 → XP_040505941.1  lissencephaly-1 homolog isoform X1

      UniProtKB/Swiss-Prot
      Q9PTR5
      UniProtKB/TrEMBL
      A0A8V1AJB6
      Conserved Domains (3) summary
      smart00667
      Location:7 → 39
      LisH; Lissencephaly type-1-like homology motif
      cd00200
      Location:104 → 408
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:111 → 148
      7WD40; WD40 repeat [structural motif]

    15. XM_025141881.3 → XP_024997649.1  lissencephaly-1 homolog isoform X1

      UniProtKB/Swiss-Prot
      Q9PTR5
      UniProtKB/TrEMBL
      A0A8V1AJB6
      Conserved Domains (3) summary
      smart00667
      Location:7 → 39
      LisH; Lissencephaly type-1-like homology motif
      cd00200
      Location:104 → 408
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:111 → 148
      7WD40; WD40 repeat [structural motif]

    16. XM_046902285.1 → XP_046758241.1  lissencephaly-1 homolog isoform X1

      UniProtKB/Swiss-Prot
      Q9PTR5

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052591.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      9660934..9690066
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046929877.1 → XP_046785833.1  lissencephaly-1 homolog isoform X1

      UniProtKB/Swiss-Prot
      Q9PTR5

    2. XM_046929878.1 → XP_046785834.1  lissencephaly-1 homolog isoform X1

      UniProtKB/Swiss-Prot
      Q9PTR5

    3. XM_046929880.1 → XP_046785836.1  lissencephaly-1 homolog isoform X1

      UniProtKB/Swiss-Prot
      Q9PTR5

    4. XM_046929885.1 → XP_046785841.1  lissencephaly-1 homolog isoform X1

      UniProtKB/Swiss-Prot
      Q9PTR5

    5. XM_046929875.1 → XP_046785831.1  lissencephaly-1 homolog isoform X1

      UniProtKB/Swiss-Prot
      Q9PTR5

    6. XM_046929874.1 → XP_046785830.1  lissencephaly-1 homolog isoform X1

      UniProtKB/Swiss-Prot
      Q9PTR5

    7. XM_046929884.1 → XP_046785840.1  lissencephaly-1 homolog isoform X1

      UniProtKB/Swiss-Prot
      Q9PTR5

    8. XM_046929882.1 → XP_046785838.1  lissencephaly-1 homolog isoform X1

      UniProtKB/Swiss-Prot
      Q9PTR5

    9. XM_046929891.1 → XP_046785847.1  lissencephaly-1 homolog isoform X1

      UniProtKB/Swiss-Prot
      Q9PTR5

    10. XM_046929881.1 → XP_046785837.1  lissencephaly-1 homolog isoform X1

      UniProtKB/Swiss-Prot
      Q9PTR5

    11. XM_046929883.1 → XP_046785839.1  lissencephaly-1 homolog isoform X1

      UniProtKB/Swiss-Prot
      Q9PTR5

    12. XM_046929888.1 → XP_046785844.1  lissencephaly-1 homolog isoform X1

      UniProtKB/Swiss-Prot
      Q9PTR5

    13. XM_046929889.1 → XP_046785845.1  lissencephaly-1 homolog isoform X1

      UniProtKB/Swiss-Prot
      Q9PTR5

    14. XM_046929886.1 → XP_046785842.1  lissencephaly-1 homolog isoform X1

      UniProtKB/Swiss-Prot
      Q9PTR5

    15. XM_046929879.1 → XP_046785835.1  lissencephaly-1 homolog isoform X1

      UniProtKB/Swiss-Prot
      Q9PTR5

    16. XM_046929890.1 → XP_046785846.1  lissencephaly-1 homolog isoform X1

      UniProtKB/Swiss-Prot
      Q9PTR5
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9PTR5.3 GenPept UniProtKB/Swiss-Prot:Q9PTR5

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