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    NBL1 neuroblastoma 1, DAN family BMP antagonist [ Gallus gallus (chicken) ]

    Gene ID: 373952, updated on 3-Apr-2024

    Summary

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    Official Symbol
    NBL1provided by CGNC
    Official Full Name
    neuroblastoma 1, DAN family BMP antagonistprovided by CGNC
    Primary source
    CGNC:2967
    See related
    Ensembl:ENSGALG00010020636
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    DAN
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 21
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 21 NC_052552.1 (4762283..4771648)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 21 NC_052593.1 (4795525..4804882)

    Chromosome 21 - NC_052552.1Genomic Context describing neighboring genes Neighboring gene capping actin protein of muscle Z-line beta subunit Neighboring gene mitochondrial inner membrane organizing system 1 Neighboring gene 5-hydroxytryptamine receptor 6 Neighboring gene transmembrane and coiled-coil domains 4 Neighboring gene ring finger protein 186

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. DAN (NBL1) promotes collective neural crest migration by restraining uncontrolled invasion. McLennan R, et al. J Cell Biol, 2017 Oct 2. PMID 28811280, Free PMC Article
    2. DAN directs endolymphatic sac and duct outgrowth in the avian inner ear. Gerlach-Bank LM, et al. Dev Dyn, 2004 Feb. PMID 14745948
    3. Cloning and expression analysis of the chick DAN gene, an antagonist of the BMP family of growth factors. Gerlach-Bank LM, et al. Dev Dyn, 2002 May. PMID 11984879
    4. Expression of the Dan gene during chicken embryonic development. Ogita J, et al. Mech Dev, 2001 Dec. PMID 11731250
    5. BMP inhibition by DAN in Hensen's node is a critical step for the establishment of left-right asymmetry in the chick embryo. Katsu K, et al. Dev Biol, 2012 Mar 1. PMID 22202776

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. results identify DAN as a novel factor that inhibits uncontrolled neural crest and metastatic melanoma invasion and promotes collective migration in a manner consistent with the inhibition of BMP signaling.
      Title: DAN (NBL1) promotes collective neural crest migration by restraining uncontrolled invasion.
    2. Data show that regulation of asymmetric Dan expression by SHH and BMP4 in Hensen's node.
      Title: BMP inhibition by DAN in Hensen's node is a critical step for the establishment of left-right asymmetry in the chick embryo.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables BMP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables receptor ligand activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in animal organ morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in sequestering of BMP from receptor via BMP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    neuroblastoma suppressor of tumorigenicity 1
    Names
    cDAN
    cysteine knot secreted protein DAN
    neuroblastoma, suppression of tumorigenicity 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_204149.5 → NP_989480.2  neuroblastoma suppressor of tumorigenicity 1 precursor

      See identical proteins and their annotated locations for NP_989480.2

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000329
      UniProtKB/TrEMBL
      A0A8V0ZF40
      Related
      ENSGALP00010029436.1, ENSGALT00010049821.1
      Conserved Domains (1) summary
      pfam03045
      Location:39 → 137
      DAN; DAN domain

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052552.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      4762283..4771648
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_040651090.2 → XP_040507024.1  neuroblastoma suppressor of tumorigenicity 1 isoform X1

      UniProtKB/Swiss-Prot
      Q8QGI6, Q90YC9
      Conserved Domains (1) summary
      cl21545
      Location:40 → 122
      GHB_like; Glycoprotein hormone beta chain homologues

    2. XM_040651089.2 → XP_040507023.1  neuroblastoma suppressor of tumorigenicity 1 isoform X1

      UniProtKB/Swiss-Prot
      Q8QGI6, Q90YC9
      Conserved Domains (1) summary
      cl21545
      Location:40 → 122
      GHB_like; Glycoprotein hormone beta chain homologues

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052593.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      4795525..4804882
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046931118.1 → XP_046787074.1  neuroblastoma suppressor of tumorigenicity 1 isoform X1

    2. XM_046931117.1 → XP_046787073.1  neuroblastoma suppressor of tumorigenicity 1 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q90YC9.2 GenPept UniProtKB/Swiss-Prot:Q90YC9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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