Fcar Fc alpha receptor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fcarprovided by RGD
Official Full Name: Fc alpha receptorprovided by RGD
Primary source: RGD:1303082
See related: AllianceGenome:RGD:1303082
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: CD89
Summary: Predicted to enable IgA binding activity and IgA receptor activity. Predicted to be involved in several processes, including cellular response to cytokine stimulus; cellular response to lipopolysaccharide; and positive regulation of cell death. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in IgA glomerulonephritis; granulomatosis with polyangiitis; and renal fibrosis. Orthologous to human FCAR (Fc fragment of IgA receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 4.4), Spleen (RPKM 3.9) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1q12

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (78669119..78703223, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (69626458..69660558, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (73230392..73263462, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The rat Fcar gene has an exon-intron structure essentially identical to that of the human counterpart and is encoded in the leukocyte receptor complex on Chromosome 1.
Title: Identification of the rat IgA Fc receptor encoded in the leukocyte receptor complex.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables IgA binding	ISO Inferred from Sequence Orthology more info
enables IgA receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Fc receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cellular response to granulocyte macrophage colony-stimulating factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to interferon-alpha	ISO Inferred from Sequence Orthology more info
involved_in cellular response to interleukin-6	ISO Inferred from Sequence Orthology more info
involved_in cellular response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
involved_in cellular response to tumor necrosis factor	ISO Inferred from Sequence Orthology more info
involved_in cellular response to type II interferon	ISO Inferred from Sequence Orthology more info
involved_in immune response-regulating signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in neutrophil activation	ISO Inferred from Sequence Orthology more info
involved_in neutrophil mediated immunity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neutrophil apoptotic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: immunoglobulin alpha Fc receptor

Names: Fc fragment of IgA receptor; Fc fragment of IgA, receptor for; IgA Fc receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_201992.1 → NP_973721.1 immunoglobulin alpha Fc receptor precursor

See identical proteins and their annotated locations for NP_973721.1

Status: PROVISIONAL

Source sequence(s)

AB109766

UniProtKB/TrEMBL

A6KNK6

Conserved Domains (1) summary

cl11960
Location:122 → 212

Ig; Immunoglobulin domain