Carm1 coactivator-associated arginine methyltransferase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Carm1provided by RGD
Official Full Name: coactivator-associated arginine methyltransferase 1provided by RGD
Primary source: RGD:1305879
See related: Ensembl:ENSRNOG00000031129 AllianceGenome:RGD:1305879
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Prmt4
Summary: Predicted to enable several functions, including lysine-acetylated histone binding activity; nuclear receptor coactivator activity; and protein-arginine N-methyltransferase activity. Involved in several processes, including negative regulation of dendrite development; regulation of mRNA binding activity; and response to cAMP. Located in cytoplasm and nucleus. Biomarker of asthma; hepatocellular adenoma; and hepatocellular carcinoma. Orthologous to human CARM1 (coactivator associated arginine methyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Muscle (RPKM 111.1), Heart (RPKM 110.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q13

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (28373370..28418056)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (20097262..20141950)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (22577723..22622555)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Blocking the Spinal Fbxo3/CARM1/K(+) Channel Epigenetic Silencing Pathway as a Strategy for Neuropathic Pain Relief.
Title: Blocking the Spinal Fbxo3/CARM1/K(+) Channel Epigenetic Silencing Pathway as a Strategy for Neuropathic Pain Relief.
Mechanistically, PRMT4 overexpression promoted hypoxia-induced cardiomyocytes apoptosis, while its inhibition abolished these effects.
Title: PRMT4 overexpression aggravates cardiac remodeling following myocardial infarction by promoting cardiomyocyte apoptosis.
These results suggest that CARM1 is a post-synaptic protein that plays roles in dendritic maturation and synaptic formation and that spatiotemporal regulation of CARM1 activity modulates neuronal connectivity and improves synaptic dysfunction.
Title: Inhibition of coactivator-associated arginine methyltransferase 1 modulates dendritic arborization and spine maturation of cultured hippocampal neurons.
The silencing of CARM1 using siRNA increased Notch1 expression, the transcriptional activity of Hes, and podocyte apoptosis.
Title: Ubiquitination-dependent CARM1 degradation facilitates Notch1-mediated podocyte apoptosis in diabetic nephropathy.
high-glucose-induced CARM1 expression increases RPE cell apoptosis via H3R17 asymmetric dimethylation
Title: High-glucose-induced CARM1 expression regulates apoptosis of human retinal pigment epithelial cells via histone 3 arginine 17 dimethylation: role in diabetic retinopathy.
aberrantly expressed CARM1 in tumor marker-positive cells promotes tumorigenesis in the early stages of hepatocarcinogenesis.
Title: Elevated expression of coactivator-associated arginine methyltransferase 1 is associated with early hepatocarcinogenesis.
PKC may play an important role in neuronal differentiation and synaptogenesis via stimulating HuD-mediated mRNA stability and inhibiting CARM1 in hippocampal neurons
Title: Protein kinase C stimulates HuD-mediated mRNA stability and protein expression of neurotrophic factors and enhances dendritic maturation of hippocampal neurons in culture.
the N-terminal and the C-terminal end of CARM1 catalytic module contain molecular switches that may determine how CARM1 regulates its biological activities by protein-protein interactions
Title: Functional insights from structures of coactivator-associated arginine methyltransferase 1 domains.
biochemical analysis of CARM1 methyltransferase and the histone code
Title: Insights into histone code syntax from structural and biochemical studies of CARM1 methyltransferase.
CARM1 has a role in signal-dependent control of gluconeogenic key enzyme genes
Title: Signal-dependent control of gluconeogenic key enzyme genes through coactivator-associated arginine methyltransferase 1.

Submit: New GeneRIF Correction See all GeneRIFs (11)

General gene information

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Markers

RH133576 (e-PCR)
- UniSTS:216859

RH141547 (e-PCR)
- UniSTS:223541

RH132083 (e-PCR)
- UniSTS:215366

Carm1 (e-PCR), detects polymorphism
- UniSTS:515959

Carm1 (e-PCR), detects polymorphism
- UniSTS:479133

RH135268 (e-PCR)
- UniSTS:218545

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables histone H3R17 methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone H3R17 methyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables histone H3R2 methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables histone H3R2 methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone H3R2 methyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables histone H3R26 methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone H3R26 methyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables histone arginine N-methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone methyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables lysine-acetylated histone binding	ISO Inferred from Sequence Orthology more info
enables lysine-acetylated histone binding	ISS Inferred from Sequence or Structural Similarity more info
enables nuclear receptor coactivator activity	ISO Inferred from Sequence Orthology more info
enables nuclear receptor coactivator activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables protein-arginine N-methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein-arginine N-methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables protein-arginine N-methyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein-arginine omega-N asymmetric methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables protein-arginine omega-N asymmetric methyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables transcription cis-regulatory region binding	ISO Inferred from Sequence Orthology more info
enables transcription cis-regulatory region binding	ISS Inferred from Sequence or Structural Similarity more info
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info
enables transcription coactivator activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in RNA splicing	IEA Inferred from Electronic Annotation more info
acts_upstream_of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in chromatin remodeling	IBA Inferred from Biological aspect of Ancestor more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within endochondral bone morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within intracellular estrogen receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in intracellular steroid hormone receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in methylation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of dendrite development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidyl-arginine methylation, to asymmetrical-dimethyl arginine	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fat cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fat cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of transcription by RNA polymerase I	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein localization to chromatin	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of growth plate cartilage chondrocyte proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of intracellular estrogen receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of intracellular estrogen receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in replication fork reversal	ISO Inferred from Sequence Orthology more info
involved_in replication fork reversal	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to cAMP	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription regulator complex	ISO Inferred from Sequence Orthology more info
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nuclear replication fork	ISO Inferred from Sequence Orthology more info
is_active_in nuclear replication fork	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: histone-arginine methyltransferase CARM1

Names: protein arginine N-methyltransferase 4

NP_001025212.1

EC 2.1.1.319

NP_001029260.1

EC 2.1.1.319

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001030041.4 → NP_001025212.1 histone-arginine methyltransferase CARM1 isoform a

See identical proteins and their annotated locations for NP_001025212.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/TrEMBL

A0A068FP44, A6JNT0

Related

ENSRNOP00000042739.3, ENSRNOT00000048245.7

Conserved Domains (2) summary

cd02440
Location:189 → 284

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

pfam11531
Location:35 → 139

CARM1; Coactivator-associated arginine methyltransferase 1 N terminal
NM_001034088.3 → NP_001029260.1 histone-arginine methyltransferase CARM1 isoform b

See identical proteins and their annotated locations for NP_001029260.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/TrEMBL

A0A068FP44

Related

ENSRNOP00000049428.5, ENSRNOT00000041577.5

Conserved Domains (2) summary

cd02440
Location:189 → 284

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

pfam11531
Location:35 → 139

CARM1; Coactivator-associated arginine methyltransferase 1 N terminal

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

28373370..28418056

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001034086.1: Suppressed sequence

Description

NM_001034086.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
NM_001034087.1: Suppressed sequence

Description

NM_001034087.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.