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    Pmel premelanosome protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362818, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Pmelprovided by RGD
    Official Full Name
    premelanosome proteinprovided by RGD
    Primary source
    RGD:1307513
    See related
    Ensembl:ENSRNOG00000023085 AllianceGenome:RGD:1307513
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Silv
    Summary
    Predicted to enable identical protein binding activity. Predicted to be involved in melanosome organization and positive regulation of melanin biosynthetic process. Predicted to act upstream of or within melanin biosynthetic process. Predicted to be located in Golgi apparatus; endoplasmic reticulum membrane; and multivesicular body membrane. Predicted to be active in melanosome. Predicted to be integral component of plasma membrane. Orthologous to human PMEL (premelanosome protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 19.0), Thymus (RPKM 13.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pmel in Genome Data Viewer
    Location:
    7q11
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (1721948..1733248)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (1138202..1148735)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (3133347..3143827)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene sulfite oxidase Neighboring gene RAB5B, member RAS oncogene family Neighboring gene uncharacterized LOC120093528 Neighboring gene cyclin dependent kinase 2 Neighboring gene diacylglycerol kinase, alpha Neighboring gene roadblock domain containing 3, pseudogene 1 Neighboring gene PYM homolog 1, exon junction complex associated factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. TYRP1 Protects Against the Apoptosis and Oxidative Stress of Retinal Ganglion Cells by Binding to PMEL. Gao Y, et al. Ocul Immunol Inflamm, 2023 Jul. PMID 35708352
    2. Effects of pH on aggregation kinetics of the repeat domain of a functional amyloid, Pmel17. Pfefferkorn CM, et al. Proc Natl Acad Sci U S A, 2010 Dec 14. PMID 21106765, Free PMC Article
    3. Epitope mapping of the melanosomal matrix protein gp100 (PMEL17): rapid processing in the endoplasmic reticulum and glycosylation in the early Golgi compartment. Yasumoto K, et al. J Biol Chem, 2004 Jul 2. PMID 15096515
    4. Pmel17 initiates premelanosome morphogenesis within multivesicular bodies. Berson JF, et al. Mol Biol Cell, 2001 Nov. PMID 11694580, Free PMC Article
    5. The repeat domain of the melanosome fibril protein Pmel17 forms the amyloid core promoting melanin synthesis. McGlinchey RP, et al. Proc Natl Acad Sci U S A, 2009 Aug 18. PMID 19666488, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TYRP1 Protects Against the Apoptosis and Oxidative Stress of Retinal Ganglion Cells by Binding to PMEL.
      Title: TYRP1 Protects Against the Apoptosis and Oxidative Stress of Retinal Ganglion Cells by Binding to PMEL.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within melanin biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in melanosome organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in melanosome organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of melanin biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cis-Golgi network membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in melanosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in melanosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in melanosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in multivesicular body membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in multivesicular body, internal vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    melanocyte protein PMEL
    Names
    melanocyte protein Pmel 17
    silver homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427188.1 → NP_001414117.1  melanocyte protein PMEL precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      1721948..1733248
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063263712.1 → XP_063119782.1  melanocyte protein PMEL isoform X2

    2. XM_039080007.2 → XP_038935935.1  melanocyte protein PMEL isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZTD1, D3ZED8
      Related
      ENSRNOP00000082328.1
      Conserved Domains (2) summary
      pfam05109
      Location:295 → 417
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam00801
      Location:223 → 289
      PKD; PKD domain

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001108729.1: Suppressed sequence

      Description
      NM_001108729.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from zebrafish: pmela (GeneID:321239).
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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