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    Mtf1 metal-regulatory transcription factor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362591, updated on 3-Apr-2024

    Summary

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    Symbol
    Mtf1provided by RGD
    Full Name
    metal-regulatory transcription factor 1provided by RGD
    Primary source
    RGD:1308956
    See related
    Ensembl:ENSRNOG00000025724 AllianceGenome:RGD:1308956
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and histone acetyltransferase binding activity. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be active in nucleus. Orthologous to human MTF1 (metal regulatory transcription factor 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 40.7), Brain (RPKM 40.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    5q36
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (142347024..142391810)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (137062319..137107136)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (142797340..142843896)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene splicing factor 3a, subunit 3 Neighboring gene uncharacterized LOC120102976 Neighboring gene inositol polyphosphate-5-phosphatase B Neighboring gene similar to human chromosome 1 open reading frame 122 Neighboring gene yrdC N(6)-threonylcarbamoyltransferase domain containing

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The hypoxia sensitive metal transcription factor MTF-1 activates NCX1 brain promoter and participates in remote postconditioning neuroprotection in stroke. Valsecchi V, et al. Cell Death Dis, 2021 Apr 30. PMID 33931586, Free PMC Article
    2. The transcription factor MTF-1 mediates metal regulation of the mouse ZnT1 gene. Langmade SJ, et al. J Biol Chem, 2000 Nov 3. PMID 10952993
    3. STAT5 proteins are involved in down-regulation of iron regulatory protein 1 gene expression by nitric oxide. Starzynski RR, et al. Biochem J, 2006 Dec 1. PMID 16886906, Free PMC Article
    4. Regulation of the catabolic cascade in osteoarthritis by the zinc-ZIP8-MTF1 axis. Kim JH, et al. Cell, 2014 Feb 13. PMID 24529376
    5. Chromium(VI) inhibits mouse metallothionein-I gene transcription by preventing the zinc-dependent formation of an MTF-1-p300 complex. Kimura T, et al. Biochem J, 2008 Nov 1. PMID 18605988

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The hypoxia sensitive metal transcription factor MTF-1 activates NCX1 brain promoter and participates in remote postconditioning neuroprotection in stroke.
      Title: The hypoxia sensitive metal transcription factor MTF-1 activates NCX1 brain promoter and participates in remote postconditioning neuroprotection in stroke.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone acetyltransferase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of cartilage homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to zinc ion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in central nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within response to cadmium ion ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    metal regulatory transcription factor 1
    Names
    metal regulatory transcription factor 1-like
    metal response element binding transcription factor 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108677.1 → NP_001102147.1  metal regulatory transcription factor 1

      See identical proteins and their annotated locations for NP_001102147.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473968
      UniProtKB/TrEMBL
      A6IS54, D3ZBT4
      Related
      ENSRNOP00000031224.4, ENSRNOT00000031928.5
      Conserved Domains (3) summary
      COG5048
      Location:92 → 290
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:235 → 252
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:244 → 270
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      142347024..142391810
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006238884.5 → XP_006238946.1  metal regulatory transcription factor 1 isoform X2

      Conserved Domains (3) summary
      COG5048
      Location:92 → 290
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:235 → 252
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:244 → 270
      zf-H2C2_2; Zinc-finger double domain

    2. XM_063288017.1 → XP_063144087.1  metal regulatory transcription factor 1 isoform X2

    3. XM_063288016.1 → XP_063144086.1  metal regulatory transcription factor 1 isoform X1

      UniProtKB/TrEMBL
      A6IS54, D3ZBT4

    4. XM_039110342.2 → XP_038966270.1  metal regulatory transcription factor 1 isoform X3

      Conserved Domains (2) summary
      COG5048
      Location:81 → 239
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:184 → 201
      ZF_C2H2; C2H2 Zn finger [structural motif]

    5. XM_039110343.2 → XP_038966271.1  metal regulatory transcription factor 1 isoform X4

      Conserved Domains (2) summary
      COG5048
      Location:76 → 241
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:174 → 191
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version

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