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    Lsp1 lymphocyte-specific protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361680, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Lsp1provided by RGD
    Official Full Name
    lymphocyte-specific protein 1provided by RGD
    Primary source
    RGD:1306133
    See related
    Ensembl:ENSRNOG00000020300 AllianceGenome:RGD:1306133
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable actin binding activity. Predicted to be involved in signal transduction. Predicted to act upstream of or within cellular response to interleukin-7; chemotaxis; and defense response. Orthologous to human LSP1 (lymphocyte specific protein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 323.0), Thymus (RPKM 309.2) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    1q41
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (207044157..207077891)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (197614677..197648414)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (215628750..215662505)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene troponin I2, fast skeletal type Neighboring gene RNA, U6 small nuclear 81 Neighboring gene synaptotagmin 8 Neighboring gene proline rich 33 Neighboring gene troponin T3, fast skeletal type Neighboring gene mitochondrial ribosomal protein L23

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Leukocyte-specific protein 1: a novel regulator of hepatocellular proliferation and migration deleted in human hepatocellular carcinoma. Koral K, et al. Hepatology, 2015 Feb. PMID 25234543, Free PMC Article
    2. LSP1 modulates leukocyte populations in resting and inflamed peritoneum. Jongstra-Bilen J, et al. Blood, 2000 Sep 1. PMID 10961883
    3. IL-7-induced phosphorylation of the adaptor Crk-like and other targets. Aiello FB, et al. Cell Signal, 2018 Jul. PMID 29581031, Free PMC Article
    4. MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Buschow SI, et al. Immunol Cell Biol, 2010 Nov-Dec. PMID 20458337
    5. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. functions as a negative regulator of proliferation and migration in hepatoma
      Title: Leukocyte-specific protein 1: a novel regulator of hepatocellular proliferation and migration deleted in human hepatocellular carcinoma.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to interleukin-7 ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within chemotaxis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within defense response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    lymphocyte-specific protein 1
    Names
    1 BAC CH230-300K22 (Children's Hospital Oakland Research Institute) complete
    lymphocyte specific 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001415989.1 → NP_001402918.1  lymphocyte-specific protein 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      Q4QQV6
      Related
      ENSRNOP00000096511.1, ENSRNOT00000119046.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      207044157..207077891
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001025420.1: Suppressed sequence

      Description
      NM_001025420.1: This RefSeq was removed because currently there is insufficient support for the transcript.
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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