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    Rdh10 retinol dehydrogenase 10 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 353252, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Rdh10provided by RGD
    Official Full Name
    retinol dehydrogenase 10provided by RGD
    Primary source
    RGD:727793
    See related
    Ensembl:ENSRNOG00000006681 AllianceGenome:RGD:727793
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable NAD-retinol dehydrogenase activity. Involved in positive regulation of retinoic acid biosynthetic process. Located in intracellular membrane-bounded organelle. Orthologous to human RDH10 (retinol dehydrogenase 10). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Liver (RPKM 180.5), Kidney (RPKM 145.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rdh10 in Genome Data Viewer
    Location:
    5q11
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (7969931..7998834, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (3186671..3215572, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (2605265..2631905, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486907 Neighboring gene staufen double-stranded RNA binding protein 2 Neighboring gene uncharacterized LOC102555040 Neighboring gene uncharacterized LOC134486911 Neighboring gene similar to human chromosome 8 open reading frame 89 Neighboring gene ribosomal protein L7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of RDH10, an All-trans Retinol Dehydrogenase, in Retinal Muller Cells. Wu BX, et al. Invest Ophthalmol Vis Sci, 2004 Nov. PMID 15505029
    2. The 11-cis-retinol dehydrogenase activity of RDH10 and its interaction with visual cycle proteins. Farjo KM, et al. Invest Ophthalmol Vis Sci, 2009 Nov. PMID 19458327
    3. Cloning and characterization of a novel all-trans retinol short-chain dehydrogenase/reductase from the RPE. Wu BX, et al. Invest Ophthalmol Vis Sci, 2002 Nov. PMID 12407145
    4. Multiple retinol and retinal dehydrogenases catalyze all-trans-retinoic acid biosynthesis in astrocytes. Wang C, et al. J Biol Chem, 2011 Feb 25. PMID 21138835, Free PMC Article
    5. Key enzymes of the retinoid (visual) cycle in vertebrate retina. Kiser PD, et al. Biochim Biophys Acta, 2012 Jan. PMID 21447403, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables all-trans-retinol dehydrogenase (NAD+) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables all-trans-retinol dehydrogenase (NADP+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within animal organ morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within bud elongation involved in lung branching ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within ear development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within embryonic camera-type eye development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within embryonic forelimb morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within embryonic organ development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within embryonic viscerocranium morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within gonad development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within in utero embryonic development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within metanephros development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neural crest cell development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within nose development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of retinoic acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within primary lung bud formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in retinal metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within retinoic acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in retinol metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retinol metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within visual perception ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in lipid droplet IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    retinol dehydrogenase 10
    Names
    retinol dehydrogenase 10 (all-trans)
    NP_852143.1
    XP_038966079.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_181478.2 → NP_852143.1  retinol dehydrogenase 10

      See identical proteins and their annotated locations for NP_852143.1

      Status: PROVISIONAL

      Source sequence(s)
      AY178865
      UniProtKB/Swiss-Prot
      Q80ZF7
      UniProtKB/TrEMBL
      A6JFB5
      Related
      ENSRNOP00000009096.2, ENSRNOT00000009096.5
      Conserved Domains (1) summary
      cd05339
      Location:38 → 307
      17beta-HSDXI-like_SDR_c; human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      7969931..7998834 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039110151.2 → XP_038966079.1  retinol dehydrogenase 10 isoform X1

      Conserved Domains (1) summary
      cd05339
      Location:1 → 142
      17beta-HSDXI-like_SDR_c; human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80ZF7.1 GenPept UniProtKB/Swiss-Prot:Q80ZF7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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