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    Klhdc1 kelch domain containing 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314190, updated on 13-Apr-2024

    Summary

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    Symbol
    Klhdc1provided by RGD
    Full Name
    kelch domain containing 1provided by RGD
    Primary source
    RGD:1308211
    See related
    Ensembl:ENSRNOG00000004425 AllianceGenome:RGD:1308211
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ubiquitin ligase-substrate adaptor activity. Predicted to be involved in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway. Predicted to be part of Cul5-RING ubiquitin ligase complex. Predicted to be active in cytosol. Orthologous to human KLHDC1 (kelch domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 32.4), Brain (RPKM 31.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    6q24
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (93406226..93501475)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (87670182..87765431)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (91532380..91584112)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L36A like 1 Neighboring gene alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase Neighboring gene dynein, axonemal, assembly factor 2 Neighboring gene DNA polymerase epsilon 2, accessory subunit Neighboring gene transcription factor BTF3-like Neighboring gene kelch domain containing 2 Neighboring gene nuclear export mediator factor Neighboring gene microRNA mir-3084a-4 Neighboring gene uncharacterized LOC134479213

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ubiquitin-like ligase-substrate adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul5-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    kelch domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108027.2 → NP_001101497.1  kelch domain-containing protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001101497.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A6HBV4, B0K005, E9PTH6
      Conserved Domains (4) summary
      sd00038
      Location:70 → 120
      Kelch; KELCH repeat [structural motif]
      pfam13415
      Location:206 → 256
      Kelch_3; Galactose oxidase, central domain
      pfam13418
      Location:247 → 295
      Kelch_4; Galactose oxidase, central domain
      pfam13854
      Location:13 → 54
      Kelch_5; Kelch motif

    2. NM_001414927.1 → NP_001401856.1  kelch domain-containing protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A0G2KAE3
      Related
      ENSRNOP00000075367.1, ENSRNOT00000082500.2

    3. NM_001414928.1 → NP_001401857.1  kelch domain-containing protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      93406226..93501475
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039112250.2 → XP_038968178.1  kelch domain-containing protein 1 isoform X2

      Conserved Domains (3) summary
      PLN02153
      Location:126 → 266
      PLN02153; epithiospecifier protein
      PLN02193
      Location:6 → 225
      PLN02193; nitrile-specifier protein
      sd00038
      Location:13 → 63
      Kelch; KELCH repeat [structural motif]

    2. XM_006240170.5 → XP_006240232.1  kelch domain-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6GDD5
      Related
      ENSRNOP00000085804.1
      Conserved Domains (4) summary
      sd00038
      Location:13 → 65
      Kelch; KELCH repeat [structural motif]
      pfam13415
      Location:78 → 124
      Kelch_3; Galactose oxidase, central domain
      pfam13418
      Location:219 → 267
      Kelch_4; Galactose oxidase, central domain
      pfam13854
      Location:13 → 54
      Kelch_5; Kelch motif

    RNA

    1. XR_010052088.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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