Zc3h12a zinc finger CCCH type containing 12A [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Zc3h12aprovided by RGD
Full Name: zinc finger CCCH type containing 12Aprovided by RGD
Primary source: RGD:1306776
See related: Ensembl:ENSRNOG00000009131 AllianceGenome:RGD:1306776
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Reg1; MCPIP-1; RGD1306776
Summary: Predicted to enable several functions, including nucleic acid binding activity; ribonuclease activity; and ribosome binding activity. Predicted to contribute to thiol-dependent deubiquitinase. Predicted to be involved in several processes, including cellular response to cytokine stimulus; negative regulation of gene expression; and regulation of intracellular signal transduction. Predicted to be located in several cellular components, including P-body; nucleoplasm; and rough endoplasmic reticulum. Predicted to be extrinsic component of endoplasmic reticulum membrane. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasmic ribonucleoprotein granule and nucleus. Human ortholog(s) of this gene implicated in hepatitis B. Orthologous to human ZC3H12A (zinc finger CCCH-type containing 12A). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 63.1), Thymus (RPKM 39.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (142661193..142670051, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (137376562..137385351, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (143111342..143120131, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

With the help of a cecal ligation puncture-induced model of acute lung injury (ALI) in rats, we demonstrated that MCPIP1 overexpression induced by MG132 can alleviate sepsis-induced pathologic changes, increase in water content and protein leakage in the lungs, and induction of systemic inflammatory mediators, and thereby improve the 7-day mortality rate in sepsis-induced ALI.
Title: MCP-induced protein 1 attenuates sepsis-induced acute lung injury by modulating macrophage polarization via the JNK/c-Myc pathway.
Since MCPIP1 expression undergoes fluctuations in islets during type 1 diabetes development in the IDDM rat and regulates the beta-cell fate upon exposure to proinflammatory cytokines, manipulations of its expression and activity might open new perspectives for type 1 diabetes treatment.
Title: MCPIP1 regulates the sensitivity of pancreatic beta-cells to cytokine toxicity.
Data suggest a vital role for MCPIP1 in alveolar macrophage apoptosis and pulmonary fibroblast activation/migration induced by SiO2.
Title: MCPIP1 Regulates Alveolar Macrophage Apoptosis and Pulmonary Fibroblast Activation After in vitro Exposure to Silica.
Regnase-1 can be induced by HMGB1 in microglia and negatively regulates HMGB1-mediated neuroinflammation and neuronal toxicity
Title: Regnase-1 in microglia negatively regulates high mobility group box 1-mediated inflammation and neuronal injury.
MiR-9 expression in acute spinal cord injury tissue was significantly lower than that in normal spinal cord tissue.
Title: MicroRNA-9 controls apoptosis of neurons by targeting monocyte chemotactic protein-induced protein 1 expression in rat acute spinal cord injury model.
Glucose-induced cardiomyocyte death is mediated via MCP-1 production and MCPIP induction, which causes ROS production, ER stress, autophagy, and cell death.
Title: Hyperglycaemia-induced cardiomyocyte death is mediated via MCP-1 production and induction of a novel zinc-finger protein MCPIP.

Submit: New GeneRIF Correction

General gene information

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Markers

RH141495 (e-PCR)
- UniSTS:223489

RH135324 (e-PCR)
- UniSTS:218601

BE101710 (e-PCR)
- UniSTS:243701

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables RNA binding	ISO Inferred from Sequence Orthology more info
enables RNA endonuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA endonuclease activity	ISO Inferred from Sequence Orthology more info
enables RNA endonuclease activity	ISS Inferred from Sequence or Structural Similarity more info
enables RNA exonuclease activity	ISO Inferred from Sequence Orthology more info
enables RNA exonuclease activity	ISS Inferred from Sequence or Structural Similarity more info
enables RNA nuclease activity	ISO Inferred from Sequence Orthology more info
enables RNA stem-loop binding	ISO Inferred from Sequence Orthology more info
enables RNA stem-loop binding	ISS Inferred from Sequence or Structural Similarity more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISS Inferred from Sequence or Structural Similarity more info
contributes_to cysteine-type deubiquitinase activity	ISO Inferred from Sequence Orthology more info
contributes_to cysteine-type deubiquitinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables mRNA 3'-UTR AU-rich region binding	ISO Inferred from Sequence Orthology more info
enables mRNA 3'-UTR AU-rich region binding	ISS Inferred from Sequence or Structural Similarity more info
enables mRNA 3'-UTR binding	ISO Inferred from Sequence Orthology more info
enables mRNA 3'-UTR binding	ISS Inferred from Sequence or Structural Similarity more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA binding	ISO Inferred from Sequence Orthology more info
enables mRNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables miRNA binding	ISO Inferred from Sequence Orthology more info
enables miRNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables nuclease activity	ISO Inferred from Sequence Orthology more info
enables nuclease activity	ISS Inferred from Sequence or Structural Similarity more info
enables ribosome binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in 3'-UTR-mediated mRNA destabilization	IBA Inferred from Biological aspect of Ancestor more info
involved_in 3'-UTR-mediated mRNA destabilization	ISO Inferred from Sequence Orthology more info
involved_in 3'-UTR-mediated mRNA destabilization	ISS Inferred from Sequence or Structural Similarity more info
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in DNA damage response	ISS Inferred from Sequence or Structural Similarity more info
involved_in T cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in T cell receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cellular response to chemokine	ISO Inferred from Sequence Orthology more info
involved_in cellular response to chemokine	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to glucose starvation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to ionomycin	ISO Inferred from Sequence Orthology more info
involved_in cellular response to ionomycin	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
involved_in cellular response to lipopolysaccharide	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to oxidative stress	ISO Inferred from Sequence Orthology more info
involved_in cellular response to sodium arsenite	ISO Inferred from Sequence Orthology more info
involved_in cellular response to tumor necrosis factor	ISO Inferred from Sequence Orthology more info
involved_in cellular response to tumor necrosis factor	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to virus	ISO Inferred from Sequence Orthology more info
involved_in immune response-activating signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in immune response-activating signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in mRNA catabolic process	ISO Inferred from Sequence Orthology more info
involved_in miRNA catabolic process	ISO Inferred from Sequence Orthology more info
involved_in miRNA catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation by host of viral genome replication	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T-helper 17 cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T-helper 17 cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of canonical NF-kappaB signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cardiac muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cardiac muscle contraction	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cytokine production involved in inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cytokine production involved in inflammatory response	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-1 beta production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-1 beta production	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-6 production	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of muscle cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of muscle cell apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of nitric oxide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of nitric oxide biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of non-canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of non-canonical NF-kappaB signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of tumor necrosis factor production	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of type II interferon production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of type II interferon production	ISS Inferred from Sequence or Structural Similarity more info
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of angiogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of autophagy	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of defense response to virus by host	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of execution phase of apoptosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fat cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fat cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of lipid storage	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mRNA catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mRNA catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of miRNA catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of p38MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein deubiquitination	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein deubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein import into nucleus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of reactive oxygen species metabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein complex oligomerization	ISO Inferred from Sequence Orthology more info
involved_in protein complex oligomerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of gene expression	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in P-body	ISO Inferred from Sequence Orthology more info
located_in P-body	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasmic ribonucleoprotein granule	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic ribonucleoprotein granule	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISS Inferred from Sequence or Structural Similarity more info
located_in rough endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in rough endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in rough endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: endoribonuclease ZC3H12A

Names: MCP-induced protein 1; Zinc finger CCCH domain-containing protein 12A; bifunctional endoribonuclease and deubiquitinase ZC3H12A; monocyte chemotactic protein-induced protein 1; regnase-1; ribonuclease ZC3H12A

NP_001071139.1

EC 3.4.19.12

XP_063143821.1

EC 3.4.19.12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.