M6pr mannose-6-phosphate receptor, cation dependent [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: M6prprovided by RGD
Full Name: mannose-6-phosphate receptor, cation dependentprovided by RGD
Primary source: RGD:1359355
See related: Ensembl:ENSRNOG00000014992 AllianceGenome:RGD:1359355
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable retromer complex binding activity. Predicted to be involved in protein targeting to lysosome. Predicted to act upstream of or within secretion of lysosomal enzymes. Predicted to be located in late endosome and perinuclear region of cytoplasm. Predicted to be active in trans-Golgi network. Orthologous to human M6PR (mannose-6-phosphate receptor, cation dependent). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Adrenal (RPKM 377.0), Kidney (RPKM 319.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q42

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (157173154..157182293)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (155501080..155510219)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (155084755..155093896)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

expression and distribution of CD-MPR is affected by decrease of testosterone in the epididymis, and this could change the distribution of lysosomal enzymes
Title: Testosterone influences the expression and distribution of the cation-dependent mannose-6-phosphate receptor in rat epididymis. Implications in the distribution of enzymes.
This evidence may also suggest that CD-MPR and CI-MPR have different functions, mainly at early stages in the development of organs.
Title: The distribution of mannose-6-phosphate receptors changes from newborns to adults in rat liver.
Data show that the CD-MPR might be regulated by hormones and that this receptor might be involved in the secretion of specific enzymes into the rat epididymis.
Title: Castration induces changes in the cation-dependent mannose-6-phosphate receptor in rat epididymis: possible implications in secretion of lysosomal enzymes.
Expression of the cation-dependent MPR (CD-MPR) and the cation-independent MPR (CI-MPR) was measured by Western blot in rat organs at 3 ages, i.e. in newborn and 10- and 90-day-old rats.
Title: Organ-specific changes in the expression of mannose-6-phosphate receptors during postnatal development in rats.
We concluded that lysosome maturation in the rat liver occurs around the 10th day after birth, and that the CD-MPR may participate in that event.
Title: Changes in phosphomannosyl ligands correlate with cation-dependent mannose-6-phosphate receptors in rat liver during perinatal development.
The distribution of the cation-independent mannose 6-phosphate receptors was studied in postnuclear subcellular fractions from two rat liver cell lines.
Title: Cation-independent mannose 6-phosphate and 78 kDa receptors for lysosomal enzyme targeting are located in different cell compartments.
The CI-MPR and components of the endosomal-lysosomal system in surviving neurons after 192-IgG-saporin treatment represents an adaptive mechanism to restore the metabolic/structural abnormalities induced by the loss of cholin-ergic neurons.
Title: Up-regulation of cation-independent mannose 6-phosphate receptor and endosomal-lysosomal markers in surviving neurons after 192-IgG-saporin administrations into the adult rat brain.

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General gene information

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Markers

AA955967 (e-PCR)
- UniSTS:246787

RH141124 (e-PCR)
- UniSTS:223120

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein domain specific binding	IEA Inferred from Electronic Annotation more info
enables retromer complex binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in lysosomal transport	ISO Inferred from Sequence Orthology more info
involved_in lysosomal transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein targeting to lysosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein targeting to lysosome	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within secretion of lysosomal enzymes	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in late endosome	ISO Inferred from Sequence Orthology more info
located_in lysosomal membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in trans-Golgi network	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: cation-dependent mannose-6-phosphate receptor

Names: CD Man-6-P receptor; CD-MPR; cation-dependent mannose-6-phosphate receptor-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.