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    Tnfaip8 TNF alpha induced protein 8 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 307428, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Tnfaip8provided by RGD
    Official Full Name
    TNF alpha induced protein 8provided by RGD
    Primary source
    RGD:1305908
    See related
    Ensembl:ENSRNOG00000026136 AllianceGenome:RGD:1305908
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable cysteine-type endopeptidase inhibitor activity involved in apoptotic process. Predicted to be involved in positive regulation of apoptotic process. Predicted to act upstream of or within defense response to Gram-positive bacterium. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm. Orthologous to human TNFAIP8 (TNF alpha induced protein 8). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 129.3), Thymus (RPKM 124.8) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    18q11
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (45370334..45486036)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (43183854..43299512)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (44664310..44779914)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene Dmx-like 1 Neighboring gene uncharacterized LOC120098294 Neighboring gene uncharacterized LOC120098293 Neighboring gene hydroxysteroid (17-beta) dehydrogenase 4 Neighboring gene uncharacterized LOC120098292 Neighboring gene family with sequence similarity 170, member A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. MiR-379 relieves myocardial injury after acute myocardial infarction by regulating tumor necrosis factor-α-induced protein 8. Dai H, et al. Panminerva Med, 2022 Mar. PMID 32414226
    2. Expression and regulation of a novel identified TNFAIP8 family is associated with diabetic nephropathy. Zhang S, et al. Biochim Biophys Acta, 2010 Nov. PMID 20699119
    3. Expression of SCC-S2, an antiapoptotic molecule, correlates with enhanced proliferation and tumorigenicity of MDA-MB 435 cells. Kumar D, et al. Oncogene, 2004 Jan 15. PMID 14724590
    4. Identification of a novel tumor necrosis factor-alpha-inducible gene, SCC-S2, containing the consensus sequence of a death effector domain of fas-associated death domain-like interleukin- 1beta-converting enzyme-inhibitory protein. Kumar D, et al. J Biol Chem, 2000 Jan 28. PMID 10644768
    5. Two genes on A/J chromosome 18 are associated with susceptibility to Staphylococcus aureus infection by combined microarray and QTL analyses. Ahn SH, et al. PLoS Pathog, 2010 Sep 2. PMID 20824097, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MiR-379 relieves myocardial injury after acute myocardial infarction by regulating tumor necrosis factor-alpha-induced protein 8.
      Title: MiR-379 relieves myocardial injury after acute myocardial infarction by regulating tumor necrosis factor-α-induced protein 8.
    2. Findings demonstrate that TNFAIP8 is one of critical components of a signal transduction pathway that links mesangial cell proliferation to diabetic renal injury.
      Title: Expression and regulation of a novel identified TNFAIP8 family is associated with diabetic nephropathy.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables molecular sequestering activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables small molecule binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within defense response to Gram-positive bacterium ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    tumor necrosis factor alpha-induced protein 8
    Names
    tumor necrosis factor, alpha-induced protein 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107387.2 → NP_001100857.2  tumor necrosis factor alpha-induced protein 8

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/TrEMBL
      A6IX01, D4A9G3
      Related
      ENSRNOP00000021972.4, ENSRNOT00000021972.6
      Conserved Domains (1) summary
      pfam05527
      Location:51 → 205
      DUF758; Domain of unknown function (DUF758)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      45370334..45486036
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006254709.5 → XP_006254771.1  tumor necrosis factor alpha-induced protein 8 isoform X3

      UniProtKB/TrEMBL
      A0A8I5Y0F2
      Related
      ENSRNOP00000076830.1
      Conserved Domains (1) summary
      pfam05527
      Location:27 → 181
      DUF758; Domain of unknown function (DUF758)

    2. XM_039096838.2 → XP_038952766.1  tumor necrosis factor alpha-induced protein 8 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K2P3
      Related
      ENSRNOP00000072322.2
      Conserved Domains (1) summary
      pfam05527
      Location:37 → 191
      DUF758; Domain of unknown function (DUF758)

    3. XM_006254708.5 → XP_006254770.1  tumor necrosis factor alpha-induced protein 8 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AJX1
      Related
      ENSRNOP00000095552.1
      Conserved Domains (1) summary
      pfam05527
      Location:31 → 185
      DUF758; Domain of unknown function (DUF758)

    4. XM_063277358.1 → XP_063133428.1  tumor necrosis factor alpha-induced protein 8 isoform X4

      UniProtKB/TrEMBL
      A6IX03
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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