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    Agpat5 1-acylglycerol-3-phosphate O-acyltransferase 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 306582, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Agpat5provided by RGD
    Official Full Name
    1-acylglycerol-3-phosphate O-acyltransferase 5provided by RGD
    Primary source
    RGD:1306405
    See related
    Ensembl:ENSRNOG00000028623 AllianceGenome:RGD:1306405
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1306405
    Summary
    Predicted to enable 1-acylglycerol-3-phosphate O-acyltransferase activity. Predicted to act upstream of or within acylglycerol metabolic process and hematopoietic progenitor cell differentiation. Predicted to be located in endoplasmic reticulum membrane and nuclear envelope. Predicted to be active in endomembrane system and mitochondrion. Orthologous to human AGPAT5 (1-acylglycerol-3-phosphate O-acyltransferase 5). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 82.9), Heart (RPKM 73.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    16q12.5
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (77641887..77688148, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (70939480..70985745, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (75812837..75855996, complement)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene pyruvate kinase M1/2 like 1 Neighboring gene XK related 5 Neighboring gene microtubule-associated protein 1 light chain 3 beta 2 Neighboring gene uncharacterized LOC134482416 Neighboring gene microcephalin 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Enzymatic activities of the human AGPAT isoform 3 and isoform 5: localization of AGPAT5 to mitochondria. Prasad SS, et al. J Lipid Res, 2011 Mar. PMID 21173190, Free PMC Article
    2. Expression and regulation of 1-acyl-sn-glycerol- 3-phosphate acyltransferases in the epidermis. Lu B, et al. J Lipid Res, 2005 Nov. PMID 16150824
    3. Cloning and characterization of murine 1-acyl-sn-glycerol 3-phosphate acyltransferases and their regulation by PPARalpha in murine heart. Lu B, et al. Biochem J, 2005 Jan 15. PMID 15367102, Free PMC Article
    4. Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7. Nagamachi A, et al. Cancer Cell, 2013 Sep 9. PMID 24029230
    5. Gene and alternative splicing annotation with AIR. Florea L, et al. Genome Res, 2005 Jan. PMID 15632090, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC188222

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 1-acylglycerol-3-phosphate O-acyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within acylglycerol metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within hematopoietic progenitor cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphatidylinositol acyl-chain remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon
    Names
    1-acylglycerol-3-phosphate O-acyltransferase 5 (lysophosphatidic acid acyltransferase, epsilon)
    NP_001128216.1
    NP_001386354.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134744.2 → NP_001128216.1  1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon isoform 1

      See identical proteins and their annotated locations for NP_001128216.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      A0A8I5ZPQ7, A0A8J8YCS6
      Conserved Domains (2) summary
      cd07990
      Location:63 → 258
      LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
      pfam16076
      Location:252 → 313
      Acyltransf_C; Acyltransferase C-terminus

    2. NM_001399425.1 → NP_001386354.1  1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      A6IWB3, B4F7C8, G3V965
      Related
      ENSRNOP00000037069.6, ENSRNOT00000031291.6
      Conserved Domains (2) summary
      cd07990
      Location:63 → 264
      LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
      pfam16076
      Location:251 → 320
      Acyltransf_C; Acyltransferase C-terminus

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      77641887..77688148 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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