Hyal3 hyaluronidase 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Hyal3provided by RGD
Official Full Name: hyaluronidase 3provided by RGD
Primary source: RGD:1303334
See related: Ensembl:ENSRNOG00000070382 AllianceGenome:RGD:1303334
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable hyaluronoglucuronidase activity and hyalurononglucosaminidase activity. Predicted to be involved in several processes, including cellular response to UV-B; cellular response to cytokine stimulus; and hyaluronan catabolic process. Predicted to be located in several cellular components, including cytoplasmic vesicle; lysosome; and sperm midpiece. Predicted to be active in acrosomal vesicle. Orthologous to human HYAL3 (hyaluronidase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Adrenal (RPKM 99.8), Lung (RPKM 53.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q32

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (117133028..117138663)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (108254385..108260020)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (116336512..116342147)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH139126 (e-PCR)
- UniSTS:221212

Nat6 (e-PCR), detects polymorphism
- UniSTS:526016

BF387601 (e-PCR)
- UniSTS:244420

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables hyaluronoglucuronidase activity	ISO Inferred from Sequence Orthology more info
enables hyalurononglucosaminidase activity	IEA Inferred from Electronic Annotation more info
NOT enables hyalurononglucosaminidase activity	ISO Inferred from Sequence Orthology more info
enables hyalurononglucosaminidase activity	ISO Inferred from Sequence Orthology more info
enables hyalurononglucosaminidase activity	ISS Inferred from Sequence or Structural Similarity more info
NOT enables virus receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in cartilage development	ISO Inferred from Sequence Orthology more info
involved_in cellular response to UV-B	ISO Inferred from Sequence Orthology more info
involved_in cellular response to interleukin-1	ISO Inferred from Sequence Orthology more info
involved_in cellular response to tumor necrosis factor	ISO Inferred from Sequence Orthology more info
involved_in hyaluronan catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in hyaluronan catabolic process	IEA Inferred from Electronic Annotation more info
involved_in hyaluronan catabolic process	ISO Inferred from Sequence Orthology more info
involved_in hyaluronan catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of ovarian follicle development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of ovarian follicle development	ISS Inferred from Sequence or Structural Similarity more info
involved_in ovarian follicle atresia	ISO Inferred from Sequence Orthology more info
involved_in ovarian follicle atresia	ISS Inferred from Sequence or Structural Similarity more info
involved_in penetration of zona pellucida	ISO Inferred from Sequence Orthology more info
involved_in penetration of zona pellucida	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of acrosomal vesicle exocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of acrosomal vesicle exocytosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to antibiotic	ISO Inferred from Sequence Orthology more info
involved_in response to virus	ISO Inferred from Sequence Orthology more info
involved_in single fertilization	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in acrosomal membrane	ISO Inferred from Sequence Orthology more info
located_in acrosomal membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in acrosomal vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in acrosomal vesicle	IEA Inferred from Electronic Annotation more info
located_in acrosomal vesicle	ISO Inferred from Sequence Orthology more info
located_in acrosomal vesicle	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	ISS Inferred from Sequence or Structural Similarity more info
located_in early endosome	IEA Inferred from Electronic Annotation more info
located_in early endosome	ISO Inferred from Sequence Orthology more info
located_in early endosome	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in lysosome	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in sperm midpiece	ISO Inferred from Sequence Orthology more info
located_in sperm midpiece	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: hyaluronidase-3

Names: hyal-3; hyaluronoglucosaminidase 3

NP_997482.2

EC 3.2.1.35

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.