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    Atp23 ATP23 metallopeptidase and ATP synthase assembly factor homolog [ Rattus norvegicus (Norway rat) ]

    Gene ID: 299828, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Atp23provided by RGD
    Official Full Name
    ATP23 metallopeptidase and ATP synthase assembly factor homologprovided by RGD
    Primary source
    RGD:1588587
    See related
    Ensembl:ENSRNOG00000045629 AllianceGenome:RGD:1588587
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Xrcc6bp1
    Summary
    Predicted to enable metal ion binding activity and metalloendopeptidase activity. Predicted to be involved in mitochondrial protein processing and mitochondrial proton-transporting ATP synthase complex assembly. Predicted to be located in several cellular components, including cell junction; cytosol; and plasma membrane. Predicted to be extrinsic component of mitochondrial inner membrane. Orthologous to human ATP23 (ATP23 metallopeptidase and ATP synthase assembly factor homolog). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 92.8), Spleen (RPKM 39.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    7q22
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (64600100..64615240, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (62714752..62729893, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (70183625..70198655, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102557532 Neighboring gene Parkinsonism associated deglycase, pseudogene 1 Neighboring gene uncharacterized LOC120093628 Neighboring gene uncharacterized LOC108351472

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Gene and alternative splicing annotation with AIR. Florea L, et al. Genome Res, 2005 Jan. PMID 15632090, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial protein processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial proton-transporting ATP synthase complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mitochondrial inner membrane protease ATP23 homolog
    Names
    XRCC6 binding protein 1
    NP_001127938.1
    XP_038934672.1
    XP_038934674.1
    XP_038934675.1
    XP_038934676.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134466.1 → NP_001127938.1  mitochondrial inner membrane protease ATP23 homolog

      See identical proteins and their annotated locations for NP_001127938.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473950
      UniProtKB/TrEMBL
      A6HQQ8
      Conserved Domains (1) summary
      pfam09768
      Location:52 → 220
      Peptidase_M76; Peptidase M76 family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      64600100..64615240 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039078744.2 → XP_038934672.1  mitochondrial inner membrane protease ATP23 homolog isoform X1

      UniProtKB/TrEMBL
      M0R4I7
      Related
      ENSRNOP00000064274.2
      Conserved Domains (1) summary
      pfam09768
      Location:52 → 234
      Peptidase_M76; Peptidase M76 family

    2. XM_039078747.2 → XP_038934675.1  mitochondrial inner membrane protease ATP23 homolog isoform X3

      Conserved Domains (1) summary
      pfam09768
      Location:1 → 148
      Peptidase_M76; Peptidase M76 family

    3. XM_039078748.2 → XP_038934676.1  mitochondrial inner membrane protease ATP23 homolog isoform X3

      Conserved Domains (1) summary
      pfam09768
      Location:1 → 148
      Peptidase_M76; Peptidase M76 family

    4. XM_039078746.2 → XP_038934674.1  mitochondrial inner membrane protease ATP23 homolog isoform X2

      Conserved Domains (1) summary
      pfam09768
      Location:52 → 165
      Peptidase_M76; Peptidase M76 family
    Nucleotide Protein Strain
    Heading Accession and Version

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