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    Birc7 baculoviral IAP repeat-containing 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 296468, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Birc7provided by RGD
    Official Full Name
    baculoviral IAP repeat-containing 7provided by RGD
    Primary source
    RGD:1562883
    See related
    Ensembl:ENSRNOG00000043311 AllianceGenome:RGD:1562883
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1562883
    Summary
    Predicted to enable cysteine-type endopeptidase inhibitor activity involved in apoptotic process and ubiquitin protein ligase activity. Predicted to be involved in several processes, including positive regulation of protein ubiquitination; protein ubiquitination; and regulation of apoptotic process. Predicted to act upstream of or within lens development in camera-type eye. Predicted to be located in several cellular components, including Golgi apparatus; centrosome; and nucleoplasm. Predicted to be active in cytoplasm and nucleus. Orthologous to human BIRC7 (baculoviral IAP repeat containing 7). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 8.0), Lung (RPKM 5.6) and 3 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    3q43
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (188425392..188430174)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (168047824..168052606)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (176438335..176443864)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene microRNA 124-3 Neighboring gene YTH N6-methyladenosine RNA binding protein F1 Neighboring gene Sodium/potassium transporting ATPase interacting 4 Neighboring gene ADP-ribosylation factor GTPase activating protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Research progress on Livin protein: an inhibitor of apoptosis. Yan B. Mol Cell Biochem, 2011 Nov. PMID 21617971
    2. Manipulation of NK cytotoxicity by the IAP family member Livin. Nachmias B, et al. Eur J Immunol, 2007 Dec. PMID 18034418
    3. Subcellular localization determines the delicate balance between the anti- and pro-apoptotic activity of Livin. Nachmias B, et al. Apoptosis, 2007 Jul. PMID 17294084
    4. Expression patterns of inhibitor of apoptosis proteins in malignant pleural mesothelioma. Gordon GJ, et al. J Pathol, 2007 Mar. PMID 17253596
    5. Birc7: A Late Fiber Gene of the Crystalline Lens. De Maria A, et al. Invest Ophthalmol Vis Sci, 2015 Jul. PMID 26218911, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within lens development in camera-type eye ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of tumor necrosis factor-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_negative_effect regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of natural killer cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    baculoviral IAP repeat-containing protein 7
    Names
    baculoviral IAP repeat-containing 7 (livin)
    NP_001292139.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001305210.1 → NP_001292139.1  baculoviral IAP repeat-containing protein 7

      See identical proteins and their annotated locations for NP_001292139.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      D4A690
      Related
      ENSRNOP00000059533.3, ENSRNOT00000068252.4
      Conserved Domains (3) summary
      cd00022
      Location:94 → 161
      BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
      pfam13920
      Location:235 → 276
      zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
      cl16941
      Location:194 → 236
      NTP-PPase; Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      188425392..188430174
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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