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    Mocs2 molybdenum cofactor synthesis 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 294753, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Mocs2provided by RGD
    Official Full Name
    molybdenum cofactor synthesis 2provided by RGD
    Primary source
    RGD:1359477
    See related
    Ensembl:ENSRNOG00000056325 AllianceGenome:RGD:1359477
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable identical protein binding activity and molybdopterin synthase activity. Predicted to be involved in Mo-molybdopterin cofactor biosynthetic process. Predicted to be located in nuclear speck. Predicted to be part of molybdopterin synthase complex. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in molybdenum cofactor deficiency type B. Orthologous to human MOCS2 (molybdenum cofactor synthesis 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Liver (RPKM 403.0), Adrenal (RPKM 365.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mocs2 in Genome Data Viewer
    Location:
    2q14
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (48237655..48249394)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (46504588..46516327)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (46980964..46992886)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103691459 Neighboring gene developmental pluripotency-associated protein 4-like Neighboring gene integrin subunit alpha 2 Neighboring gene small nucleolar RNA SNORA44 Neighboring gene integrin subunit alpha 1 Neighboring gene pelota mRNA surveillance and ribosome rescue factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The two subunits of human molybdopterin synthase: evidence for a bicistronic messenger RNA with overlapping reading frames. Sloan J, et al. Nucleic Acids Res, 1999 Feb 1. PMID 9889283, Free PMC Article
    2. Mechanistic studies of human molybdopterin synthase reaction and characterization of mutants identified in group B patients of molybdenum cofactor deficiency. Leimkuhler S, et al. J Biol Chem, 2003 Jul 11. PMID 12732628
    3. Human molybdopterin synthase gene: genomic structure and mutations in molybdenum cofactor deficiency type B. Reiss J, et al. Am J Hum Genet, 1999 Mar. PMID 10053004, Free PMC Article
    4. Cell biology of molybdenum. Mendel RR, et al. Biochim Biophys Acta, 2006 Jul. PMID 16784786
    5. Evidence for the physiological role of a rhodanese-like protein for the biosynthesis of the molybdenum cofactor in humans. Matthies A, et al. Proc Natl Acad Sci U S A, 2004 Apr 20. PMID 15073332, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC94220

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to molybdopterin synthase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to molybdopterin synthase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in Mo-molybdopterin cofactor biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in Mo-molybdopterin cofactor biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in molybdopterin cofactor biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of molybdopterin synthase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    molybdopterin synthase catalytic subunit; molybdopterin synthase sulfur carrier subunit
    Names
    MOCS2B
    molybdenum cofactor synthesis protein 2 large subunit
    molybdenum cofactor synthesis protein 2B
    NP_001007634.1
    NP_001155885.1
    NP_001382596.1
    NP_001382597.1
    NP_001382598.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007633.2 → NP_001007634.1  molybdopterin synthase catalytic subunit isoform Mocs2B-1

      See identical proteins and their annotated locations for NP_001007634.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the 5' end, compared to variant 1, and encodes the large subunit (Mocs2B).
      Source sequence(s)
      BC079181, CO554692, FM123325
      UniProtKB/Swiss-Prot
      Q6AY59
      UniProtKB/TrEMBL
      A6I5S7, A6I5T0
      Related
      ENSRNOP00000073722.1, ENSRNOT00000082990.2
      Conserved Domains (1) summary
      cd00756
      Location:65 → 189
      MoaE; MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and ...

    2. NM_001162413.1 → NP_001155885.1  molybdopterin synthase sulfur carrier subunit isoform Mocs2A

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the small subunit (Mocs2A).
      Source sequence(s)
      BC079181, CO554692
      UniProtKB/Swiss-Prot
      Q6AY59
      Conserved Domains (1) summary
      cd00754
      Location:7 → 88
      Ubl_MoaD; ubiquitin-like (Ubl) domain found in molybdenum cofactor biosynthesis protein D (MoaD) and similar proteins

    3. NM_001395667.1 → NP_001382596.1  molybdopterin synthase catalytic subunit isoform Mocs2B-2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A6I5S8, A6I5T1
      Conserved Domains (1) summary
      cd00756
      Location:54 → 178
      MoaE; MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and ...

    4. NM_001395668.1 → NP_001382597.1  molybdopterin synthase sulfur carrier subunit isoform Mocs2A

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      Conserved Domains (1) summary
      cd00754
      Location:7 → 88
      Ubl_MoaD; ubiquitin-like (Ubl) domain found in molybdenum cofactor biosynthesis protein D (MoaD) and similar proteins

    5. NM_001395669.1 → NP_001382598.1  molybdopterin synthase sulfur carrier subunit isoform Mocs2A

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      Conserved Domains (1) summary
      cd00754
      Location:7 → 88
      Ubl_MoaD; ubiquitin-like (Ubl) domain found in molybdenum cofactor biosynthesis protein D (MoaD) and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      48237655..48249394
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6AY59.1 GenPept UniProtKB/Swiss-Prot:Q6AY59

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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