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    Alg8 ALG8, alpha-1,3-glucosyltransferase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 293129, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Alg8provided by RGD
    Official Full Name
    ALG8, alpha-1,3-glucosyltransferaseprovided by RGD
    Primary source
    RGD:1305468
    See related
    Ensembl:ENSRNOG00000012292 AllianceGenome:RGD:1305468
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable alpha-1,3-mannosyltransferase activity and dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity. Predicted to be involved in oligosaccharide-lipid intermediate biosynthetic process and protein N-linked glycosylation via asparagine. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Ih and polycystic liver disease. Orthologous to human ALG8 (ALG8 alpha-1,3-glucosyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 42.6), Adrenal (RPKM 39.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    1q32
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (161095570..161115533)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (151684344..151704310)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (162342061..162362139)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 35 Neighboring gene potassium channel tetramerization domain containing 21 Neighboring gene NADH:ubiquinone oxidoreductase subunit C2 Neighboring gene thyroid hormone responsive

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A deficiency in dolichyl-P-glucose:Glc1Man9GlcNAc2-PP-dolichyl alpha3-glucosyltransferase defines a new subtype of congenital disorders of glycosylation. Chantret I, et al. J Biol Chem, 2003 Mar 14. PMID 12480927
    2. Isolated polycystic liver disease genes define effectors of polycystin-1 function. Besse W, et al. J Clin Invest, 2017 May 1. PMID 28375157, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC124750

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables alpha-1,3-mannosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in oligosaccharide-lipid intermediate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein N-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein N-linked glycosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein N-linked glycosylation via asparagine ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase
    Names
    asparagine-linked glycosylation 8 homolog (S. cerevisiae, alpha-1,3-glucosyltransferase)
    asparagine-linked glycosylation 8 homolog (yeast, alpha-1,3-glucosyltransferase)
    asparagine-linked glycosylation 8, alpha-1,3-glucosyltransferase homolog
    dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase
    NP_001029299.1
    XP_038961896.1
    XP_038961899.1
    XP_038961911.1
    XP_063141081.1
    XP_063141092.1
    XP_063141103.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001034127.1 → NP_001029299.1  probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase precursor

      See identical proteins and their annotated locations for NP_001029299.1

      Status: PROVISIONAL

      Source sequence(s)
      BC100614
      UniProtKB/TrEMBL
      E9PT91, Q497D1
      Related
      ENSRNOP00000016478.5, ENSRNOT00000016478.7
      Conserved Domains (1) summary
      pfam03155
      Location:22 → 507
      Alg6_Alg8; ALG6, ALG8 glycosyltransferase family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      161095570..161115533
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039105968.2 → XP_038961896.1  probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase isoform X1

      Conserved Domains (1) summary
      pfam03155
      Location:22 → 370
      Alg6_Alg8; ALG6, ALG8 glycosyltransferase family

    2. XM_063285022.1 → XP_063141092.1  probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase isoform X5

    3. XM_063285011.1 → XP_063141081.1  probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase isoform X4

    4. XM_063285033.1 → XP_063141103.1  probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase isoform X6

    5. XM_039105971.2 → XP_038961899.1  probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase isoform X2

      UniProtKB/TrEMBL
      E9PT91
      Conserved Domains (1) summary
      pfam03155
      Location:1 → 419
      Alg6_Alg8; ALG6, ALG8 glycosyltransferase family

    6. XM_039105983.2 → XP_038961911.1  probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase isoform X3

      UniProtKB/TrEMBL
      A6I689
      Conserved Domains (1) summary
      cl21590
      Location:75 → 264
      PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase

    RNA

    1. XR_005501993.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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