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    Tesc tescalcin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 288689, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Tescprovided by RGD
    Official Full Name
    tescalcinprovided by RGD
    Primary source
    RGD:1566317
    See related
    Ensembl:ENSRNOG00000001128 AllianceGenome:RGD:1566317
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1566317
    Summary
    Predicted to enable metal ion binding activity; phosphatase inhibitor activity; and protein homodimerization activity. Predicted to be involved in several processes, including cellular response to retinoic acid; positive regulation of macromolecule metabolic process; and positive regulation of myeloid cell differentiation. Predicted to act upstream of or within male gonad development and megakaryocyte differentiation. Predicted to be located in several cellular components, including lamellipodium; nucleoplasm; and ruffle. Orthologous to human TESC (tescalcin). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 1395.4), Brain (RPKM 203.9) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    12q16
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (44182741..44216574, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (38521832..38555665, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (44141258..44174701, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene harakiri, BCL2 interacting protein Neighboring gene F-box and WD repeat domain containing 8 Neighboring gene uncharacterized LOC134481299 Neighboring gene F-box protein 21 Neighboring gene uncharacterized LOC120095990 Neighboring gene nitric oxide synthase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Megakaryocyte development is normal in mice with targeted disruption of Tescalcin. Ukarapong S, et al. Exp Cell Res, 2012 Mar 10. PMID 22285131
    2. Up- or downregulation of tescalcin in HL-60 cells is associated with their differentiation to either granulocytic or macrophage-like lineage. Levay K, et al. Exp Cell Res, 2010 Apr 15. PMID 20060826, Free PMC Article
    3. Calcineurin B homologous protein 3 promotes the biosynthetic maturation, cell surface stability, and optimal transport of the Na+/H+ exchanger NHE1 isoform. Zaun HC, et al. J Biol Chem, 2008 May 2. PMID 18321853, Free PMC Article
    4. Characterization of tescalcin, a novel EF-hand protein with a single Ca2+-binding site: metal-binding properties, localization in tissues and cells, and effect on calcineurin. Gutierrez-Ford C, et al. Biochemistry, 2003 Dec 16. PMID 14661968
    5. Controlled release systems containing solid dispersions: strategies and mechanisms. Tran PH, et al. Pharm Res, 2011 Oct. PMID 21553168

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calcium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to retinoic acid ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in male gonad development ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT involved_in megakaryocyte development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in megakaryocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell population proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of gene expression ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of granulocyte differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of granulocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of megakaryocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of megakaryocyte differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of sodium:proton antiporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein maturation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein stabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell adhesion mediated by integrin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cell adhesion mediated by integrin ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell adhesion mediated by integrin ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lamellipodium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lamellipodium ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in ruffle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ruffle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    calcineurin B homologous protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001398612.1 → NP_001385541.1  calcineurin B homologous protein 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      Related
      ENSRNOP00000088101.1, ENSRNOT00000114089.1
      Conserved Domains (1) summary
      COG5126
      Location:20 → 142
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      44182741..44216574 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006249426.4 → XP_006249488.1  calcineurin B homologous protein 3 isoform X1

      Conserved Domains (2) summary
      pfam13499
      Location:148 → 223
      EF-hand_7; EF-hand domain pair
      cl08302
      Location:147 → 175
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    2. XM_039090180.1 → XP_038946108.1  calcineurin B homologous protein 3 isoform X3

      UniProtKB/TrEMBL
      A0A8I6AI44
      Related
      ENSRNOP00000092418.1, ENSRNOT00000104891.1
      Conserved Domains (1) summary
      COG5126
      Location:10 → 132
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

    3. XM_039090179.1 → XP_038946107.1  calcineurin B homologous protein 3 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AI44
      Conserved Domains (2) summary
      COG5126
      Location:103 → 165
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      pfam13499
      Location:135 → 215
      EF-hand_7; EF-hand domain pair
    Nucleotide Protein Strain
    Heading Accession and Version

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