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    GPR3 G protein-coupled receptor 3 [ Homo sapiens (human) ]

    Gene ID: 2827, updated on 5-Mar-2024

    Summary

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    Official Symbol
    GPR3provided by HGNC
    Official Full Name
    G protein-coupled receptor 3provided by HGNC
    Primary source
    HGNC:HGNC:4484
    See related
    Ensembl:ENSG00000181773 MIM:600241; AllianceGenome:HGNC:4484
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ACCA
    Summary
    This gene is a member of the G protein-coupled receptor family and is found in the cell membrane. G protein-coupled receptors, characterized by a seven transmembrane domain motif, are involved in translating outside signals into G protein mediated intracellular effects. The encoded protein activates adenylate cyclase and modulates amyloid-beta production in a mouse model, suggesting that it may play a role in Alzheimer's disease. [provided by RefSeq, Oct 2012]
    Expression
    Broad expression in brain (RPKM 2.0), thyroid (RPKM 0.6) and 17 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    1p36.11
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (27392622..27395814)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (27233946..27237138)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (27719126..27722318)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ficolin 3 Neighboring gene CD164 molecule like 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:27717742-27718278 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:27718279-27718815 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 515 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:27719353-27719888 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:27720717-27721514 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:27725651-27726603 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 547 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 548 Neighboring gene Sharpr-MPRA regulatory region 8314 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 549 Neighboring gene WASP family member 2 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:27756559-27757532 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 550 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 516 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 551 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 552 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 517 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 518 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:27816920-27817464 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:27817465-27818009 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 554 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:27830147-27830734 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:27830735-27831320 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:27831321-27831907 Neighboring gene uncharacterized LOC105376892 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:27849319-27849901 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:27851813-27852451 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 519 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 520 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:27855359-27856073

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Development of a High-Throughput Screening-Compatible Assay for Discovery of GPR3 Inverse Agonists Using a cAMP Biosensor. Ayukawa K, et al. SLAS Discov, 2020 Mar. PMID 31516076
    2. [G protein-coupled receptor 3: a key factor in the regulation of the nervous system and follicle development]. Zhang BL, et al. Yi Chuan, 2013 May. PMID 23732663
    3. GPR3 may not be a potential candidate gene for premature ovarian failure. Zhou S, et al. Reprod Biomed Online, 2010 Jan. PMID 20158988
    4. Oocyte-specific G-protein-coupled receptor 3 (GPR3): no perturbations found in 82 women with premature ovarian failure (first report). Kovanci E, et al. Fertil Steril, 2008 Oct. PMID 17953967
    5. Molecular cloning of an orphan G-protein-coupled receptor that constitutively activates adenylate cyclase. Eggerickx D, et al. Biochem J, 1995 Aug 1. PMID 7639700, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Rare variants in GPR3 in POI patients: a case series with review of literature.
      Title: Rare variants in GPR3 in POI patients: a case series with review of literature.
    2. Lipolysis drives expression of the constitutively active receptor GPR3 to induce adipose thermogenesis.
      Title: Lipolysis drives expression of the constitutively active receptor GPR3 to induce adipose thermogenesis.
    3. Silencing the G-protein coupled receptor 3-salt inducible kinase 2 pathway promotes human beta cell proliferation.
      Title: Silencing the G-protein coupled receptor 3-salt inducible kinase 2 pathway promotes human β cell proliferation.
    4. Development of a High-Throughput Screening-Compatible Assay for Discovery of GPR3 Inverse Agonists Using a cAMP Biosensor.
      Title: Development of a High-Throughput Screening-Compatible Assay for Discovery of GPR3 Inverse Agonists Using a cAMP Biosensor.
    5. these results suggest an important role of the allosteric sodium binding site for GPR3 activity and open a possible avenue for the modulation of Abeta production in the Alzheimer's Disease.
      Title: Allosteric sodium binding cavity in GPR3: a novel player in modulation of Aβ production.
    6. Results demonstrate that GPR3 signals at the plasma membrane and can be silenced by GRK2/beta-arrestin overexpression. These results also strongly implicate the serine and/or threonine residues in the third intracellular loop in the regulation of GPR3 activity.
      Title: Regulation of Constitutive GPR3 Signaling and Surface Localization by GRK2 and β-arrestin-2 Overexpression in HEK293 Cells.
    7. Gpr3 stimulates Abeta production via interactions with APP and beta-arrestin2.
      Title: Gpr3 stimulates Aβ production via interactions with APP and β-arrestin2.
    8. GPR3 is a key factor in the regulation of the nervous system and follicle development.[review]
      Title: [G protein-coupled receptor 3: a key factor in the regulation of the nervous system and follicle development].
    9. GPR3 is expressed in the ovary and testes, and is necessary for the regulation of meiosis in mouse.
      Title: The Gs-linked receptor GPR3 maintains meiotic arrest in mammalian oocytes.
    10. Mutations in GPR3 are not a common cause of premature ovarian failure in Chinese women.
      Title: GPR3 may not be a potential candidate gene for premature ovarian failure.
    Submit: New GeneRIF Correction See all GeneRIFs (13)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cAMP-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cold-induced thermogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in regulation of cytosolic calcium ion concentration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of meiotic nuclear division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    G-protein coupled receptor 3
    Names
    ACCA orphan receptor
    adenylate cyclase constitutive activator

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005281.4 → NP_005272.1  G-protein coupled receptor 3

      See identical proteins and their annotated locations for NP_005272.1

      Status: REVIEWED

      Source sequence(s)
      FO393419
      Consensus CDS
      CCDS303.1
      UniProtKB/Swiss-Prot
      A8K570, P46089
      UniProtKB/TrEMBL
      F1DAM5
      Related
      ENSP00000363136.3, ENST00000374024.4
      Conserved Domains (2) summary
      cd14964
      Location:43 → 67
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:41 → 308
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      27392622..27395814
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      27233946..27237138
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P46089.1 GenPept UniProtKB/Swiss-Prot:P46089

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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