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    CSNK1A1 casein kinase 1 alpha 1 [ Bos taurus (cattle) ]

    Gene ID: 282684, updated on 3-Apr-2024

    Summary

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    Official Symbol
    CSNK1A1provided by VGNC
    Official Full Name
    casein kinase 1 alpha 1provided by VGNC
    Primary source
    VGNC:VGNC:55205
    See related
    BGD:BT25775; Ensembl:ENSBTAG00000005326
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 7
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 7 NC_037334.1 (60856710..60906241, complement)

    Chromosome 7 - NC_037334.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC132345768 Neighboring gene microRNA mir-143 Neighboring gene microRNA mir-145 Neighboring gene Rho guanine nucleotide exchange factor 37 Neighboring gene transfer RNA cysteine (anticodon ACA) Neighboring gene PPARG coactivator 1 beta Neighboring gene microRNA mir-378-1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037334.1 Chromosome 7 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Development of a biosensor immunoassay for the quantification of alphas1-casein in milk. Muller-Renaud S, et al. J Dairy Res, 2005 Feb. PMID 15747732
    2. Isolation and solubilization of casein kinase from Golgi apparatus of bovine mammary gland and phosphorylation of peptides. Szymanski ES, et al. Biochim Biophys Acta, 1982 Apr 3. PMID 6952938
    3. Purification of casein kinase I and isolation of cDNAs encoding multiple casein kinase I-like enzymes. Rowles J, et al. Proc Natl Acad Sci U S A, 1991 Nov 1. PMID 1946367, Free PMC Article
    4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Sensitivy of a biosensor to detect alphas1-CN concentrations ranging from 8.8 to 12.06 mg/ml.
      Title: Development of a biosensor immunoassay for the quantification of alphas1-casein in milk.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC133860

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of canonical Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in peptidyl-serine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    casein kinase I isoform alpha; casein kinase I
    Names
    CK1
    CKI-alpha
    casein kinase I-alpha
    NP_777136.1
    XP_005209607.1
    XP_005209608.1
    XP_005209609.1
    XP_005209610.1
    XP_005209611.1
    XP_005209613.1
    XP_005209614.1
    XP_010805724.1
    XP_024849629.1
    XP_024849630.1
    XP_024849631.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174711.2 → NP_777136.1  casein kinase I isoform alpha

      See identical proteins and their annotated locations for NP_777136.1

      Status: PROVISIONAL

      Source sequence(s)
      M76543
      UniProtKB/Swiss-Prot
      P35506, P67827, Q9GLY1, Q9GLY2, Q9GLY3
      UniProtKB/TrEMBL
      A0A3Q1MI36
      Conserved Domains (1) summary
      cd14128
      Location:16 → 281
      STKc_CK1_alpha; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 alpha

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037334.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      60856710..60906241 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005209556.5 → XP_005209613.1  casein kinase I isoform X10

      See identical proteins and their annotated locations for XP_005209613.1

      UniProtKB/TrEMBL
      A0A3Q1MI36
      Related
      ENSBTAP00000096556.1, ENSBTAT00000113060.1
      Conserved Domains (1) summary
      cd14128
      Location:16 → 281
      STKc_CK1_alpha; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 alpha

    2. XM_005209554.5 → XP_005209611.1  casein kinase I isoform X7

      See identical proteins and their annotated locations for XP_005209611.1

      UniProtKB/TrEMBL
      A0A3Q1MI36
      Conserved Domains (1) summary
      cd14128
      Location:16 → 309
      STKc_CK1_alpha; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 alpha

    3. XM_005209551.5 → XP_005209608.1  casein kinase I isoform X4

      See identical proteins and their annotated locations for XP_005209608.1

      UniProtKB/TrEMBL
      A0A3Q1MI36
      Related
      ENSBTAP00000098382.1, ENSBTAT00000118261.1
      Conserved Domains (1) summary
      cd14128
      Location:16 → 309
      STKc_CK1_alpha; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 alpha

    4. XM_024993861.2 → XP_024849629.1  casein kinase I isoform X3

      UniProtKB/TrEMBL
      A0A3Q1MI36
      Conserved Domains (1) summary
      cd14128
      Location:16 → 309
      STKc_CK1_alpha; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 alpha

    5. XM_024993862.2 → XP_024849630.1  casein kinase I isoform X8

      UniProtKB/TrEMBL
      A0A3Q1MI36
      Conserved Domains (1) summary
      cd14128
      Location:16 → 281
      STKc_CK1_alpha; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 alpha

    6. XM_010807422.3 → XP_010805724.1  casein kinase I isoform X1

      UniProtKB/TrEMBL
      A0A3Q1LK11, A0A3Q1MI36
      Related
      ENSBTAP00000056925.1, ENSBTAT00000086663.2
      Conserved Domains (2) summary
      COG0515
      Location:16 → 267
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd14128
      Location:16 → 309
      STKc_CK1_alpha; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 alpha

    7. XM_005209557.2 → XP_005209614.1  casein kinase I isoform X11

      See identical proteins and their annotated locations for XP_005209614.1

      UniProtKB/TrEMBL
      A0A3Q1MI36, Q32LI4
      Related
      ENSBTAP00000035028.2, ENSBTAT00000035150.3
      Conserved Domains (1) summary
      cd14128
      Location:16 → 281
      STKc_CK1_alpha; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 alpha

    8. XM_024993863.2 → XP_024849631.1  casein kinase I isoform X9

      UniProtKB/TrEMBL
      A0A3Q1MI36
      Related
      ENSBTAP00000007007.4, ENSBTAT00000007007.5
      Conserved Domains (1) summary
      cd14128
      Location:16 → 281
      STKc_CK1_alpha; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 alpha

    9. XM_005209553.2 → XP_005209610.1  casein kinase I isoform X6

      See identical proteins and their annotated locations for XP_005209610.1

      UniProtKB/TrEMBL
      A0A3Q1MI36
      Conserved Domains (1) summary
      cd14128
      Location:16 → 309
      STKc_CK1_alpha; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 alpha

    10. XM_005209550.2 → XP_005209607.1  casein kinase I isoform X2

      See identical proteins and their annotated locations for XP_005209607.1

      UniProtKB/TrEMBL
      A0A3Q1MI36
      Conserved Domains (1) summary
      cd14128
      Location:16 → 309
      STKc_CK1_alpha; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 alpha

    11. XM_005209552.2 → XP_005209609.1  casein kinase I isoform X5

      See identical proteins and their annotated locations for XP_005209609.1

      UniProtKB/TrEMBL
      A0A3Q1MI36
      Conserved Domains (1) summary
      cd14128
      Location:16 → 309
      STKc_CK1_alpha; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 alpha

    RNA

    1. XR_003035337.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P67827.1 GenPept UniProtKB/Swiss-Prot:P67827

    Gene LinkOut

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