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    drd3 dopamine receptor D3 [ Danio rerio (zebrafish) ]

    Gene ID: 282554, updated on 11-Apr-2024

    Summary

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    Official Symbol
    drd3provided by ZNC
    Official Full Name
    dopamine receptor D3provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-021119-1
    See related
    Ensembl:ENSDARG00000032131 AllianceGenome:ZFIN:ZDB-GENE-021119-1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Summary
    Predicted to enable G protein-coupled receptor activity and dopamine neurotransmitter receptor activity, coupled via Gi/Go. Predicted to be involved in several processes, including G protein-coupled receptor signaling pathway; negative regulation of adenylate cyclase activity; and regulation of ion transport. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Is expressed in myotome; nervous system; and somite. Human ortholog(s) of this gene implicated in Parkinson's disease; essential tremor; essential tremor 1; and schizophrenia. Orthologous to human DRD3 (dopamine receptor D3). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 24
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (20967237..21006357)
    105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (20823724..20861900)

    Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene si:ch211-161h7.8 Neighboring gene karyopherin alpha 1 (importin alpha 5) Neighboring gene queuine tRNA-ribosyltransferase accessory subunit 2 Neighboring gene coiled-coil domain containing 191

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Evolution and expression of D2 and D3 dopamine receptor genes in zebrafish. Boehmler W, et al. Dev Dyn, 2004 Jul. PMID 15188433
    2. Dopamine Receptors Gene Expression Pattern and Locomotor Improvement Differ Between Female and Male Zebrafish During Spinal Cord Auto Repair. Hosseini P, et al. Zebrafish, 2022 Aug. PMID 35905303
    3. Neuroprotective effects of Tongtian oral liquid, a Traditional Chinese Medicine in the Parkinson's disease-induced zebrafish model. Dongjie S, et al. Biomed Pharmacother, 2022 Apr. PMID 35152046
    4. Heritable and precise zebrafish genome editing using a CRISPR-Cas system. Hwang WY, et al. PLoS One, 2013. PMID 23874735, Free PMC Article
    5. Sleep deprivation caused a memory defects and emotional changes in a rotenone-based zebrafish model of Parkinson's disease. Lv DJ, et al. Behav Brain Res, 2019 Oct 17. PMID 31195038

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The evolution and expression of derd3 were studied.
      Title: Evolution and expression of D2 and D3 dopamine receptor genes in zebrafish.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables alpha2-adrenergic receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dopamine neurotransmitter receptor activity, coupled via Gi/Go IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in adenylate cyclase-activating adrenergic receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in adenylate cyclase-inhibiting adrenergic receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in adenylate cyclase-inhibiting dopamine receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of adenylate cyclase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of cytosolic calcium ion concentration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of synaptic transmission, glutamatergic IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of voltage-gated calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipase C-activating dopamine receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of dopamine secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of potassium ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    D(3) dopamine receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_183067.1 → NP_898890.1  D(3) dopamine receptor

      See identical proteins and their annotated locations for NP_898890.1

      Status: PROVISIONAL

      Source sequence(s)
      AY183455
      UniProtKB/TrEMBL
      Q8AWE1
      Related
      ENSDARP00000104546.1, ENSDART00000129675.2
      Conserved Domains (2) summary
      pfam00001
      Location:52 → 437
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:50 → 225
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007135.7 Reference GRCz11 Primary Assembly

      Range
      20967237..21006357
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021470111.1 → XP_021325786.1  D(3) dopamine receptor isoform X2

      UniProtKB/TrEMBL
      A0A8M9PTW6
      Conserved Domains (2) summary
      cd14964
      Location:51 → 75
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:49 → 461
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    2. XM_005162673.4 → XP_005162730.1  D(3) dopamine receptor isoform X1

      UniProtKB/TrEMBL
      A0A8M2B9M1, F1QG18
      Related
      ENSDARP00000109548.2, ENSDART00000130568.4
      Conserved Domains (2) summary
      pfam00001
      Location:70 → 455
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:68 → 243
      7tm_4; Olfactory receptor

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395170.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      4652..32540
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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