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    UPK1A uroplakin 1A [ Bos taurus (cattle) ]

    Gene ID: 282112, updated on 5-Mar-2024

    Summary

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    Official Symbol
    UPK1Aprovided by VGNC
    Official Full Name
    uroplakin 1Aprovided by VGNC
    Primary source
    VGNC:VGNC:36684
    See related
    BGD:BT21758; Ensembl:ENSBTAG00000020543
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 18
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 18 NC_037345.1 (46395892..46405039)

    Chromosome 18 - NC_037345.1Genomic Context describing neighboring genes Neighboring gene cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) Neighboring gene transfer RNA threonine (anticodon UGU) Neighboring gene zinc finger and BTB domain containing 32 Neighboring gene lysine methyltransferase 2B

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037345.1 Chromosome 18 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Uroplakins Ia and Ib, two major differentiation products of bladder epithelium, belong to a family of four transmembrane domain (4TM) proteins. Yu J, et al. J Cell Biol, 1994 Apr. PMID 8138569, Free PMC Article
    2. Uroplakin Ia is the urothelial receptor for uropathogenic Escherichia coli: evidence from in vitro FimH binding. Zhou G, et al. J Cell Sci, 2001 Nov. PMID 11739641
    3. Organization of uroplakin subunits: transmembrane topology, pair formation and plaque composition. Liang FX, et al. Biochem J, 2001 Apr 1. PMID 11256943, Free PMC Article
    4. SNX31: a novel sorting nexin associated with the uroplakin-degrading multivesicular bodies in terminally differentiated urothelial cells. Vieira N, et al. PLoS One, 2014. PMID 24914955, Free PMC Article
    5. Selective interactions of UPIa and UPIb, two members of the transmembrane 4 superfamily, with distinct single transmembrane-domained proteins in differentiated urothelial cells. Wu XR, et al. J Biol Chem, 1995 Dec 15. PMID 8530366

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These data support a model in which SNX31 mediates the endocytic degradation of uroplakins.
      Title: SNX31: a novel sorting nexin associated with the uroplakin-degrading multivesicular bodies in terminally differentiated urothelial cells.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    uroplakin-1a
    Names
    UP1a
    UPIa
    uroplakin IA

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_176611.2 → NP_788784.1  uroplakin-1a

      See identical proteins and their annotated locations for NP_788784.1

      Status: PROVISIONAL

      Source sequence(s)
      Z29475
      UniProtKB/Swiss-Prot
      P38572
      Related
      ENSBTAP00000027372.6, ENSBTAT00000027372.6
      Conserved Domains (2) summary
      cd03156
      Location:112 → 230
      uroplakin_I_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
      pfam00335
      Location:19 → 255
      Tetraspannin; Tetraspanin family

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037345.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      46395892..46405039
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005218903.5 → XP_005218960.1  uroplakin-1a isoform X1

      UniProtKB/TrEMBL
      F1N7A6
      Conserved Domains (2) summary
      cd03156
      Location:139 → 257
      uroplakin_I_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
      pfam00335
      Location:51 → 282
      Tetraspannin; Tetraspanin family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38572.1 GenPept UniProtKB/Swiss-Prot:P38572

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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