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    IKBKG inhibitor of nuclear factor kappa B kinase regulatory subunit gamma [ Bos taurus (cattle) ]

    Gene ID: 281855, updated on 4-Apr-2024

    Summary

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    Official Symbol
    IKBKGprovided by VGNC
    Official Full Name
    inhibitor of nuclear factor kappa B kinase regulatory subunit gammaprovided by VGNC
    Primary source
    VGNC:VGNC:30102
    See related
    BGD:BT11757; Ensembl:ENSBTAG00000006268
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: X
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) X NC_037357.1 (37582609..37641404)

    Chromosome X - NC_037357.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 10 member 3 Neighboring gene FAM3 metabolism regulating signaling molecule A Neighboring gene glucose-6-phosphate dehydrogenase Neighboring gene putative RNA-binding protein 15B Neighboring gene uncharacterized LOC112445126 Neighboring gene EKC/KEOPS complex subunit LAGE3-like Neighboring gene protein PRRC2B-like Neighboring gene small nucleolar RNA SNORD62

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037357.1 Chromosome X Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of the bovine IkappaB kinases (IKK)alpha and IKKbeta, the regulatory subunit NEMO and their substrate IkappaBalpha. Rottenberg S, et al. Gene, 2002 Oct 16. PMID 12459277
    2. Sequence evaluation of four pooled-tissue normalized bovine cDNA libraries and construction of a gene index for cattle. Smith TP, et al. Genome Res, 2001 Apr. PMID 11282978, Free PMC Article
    3. Characterization of 954 bovine full-CDS cDNA sequences. Harhay GP, et al. BMC Genomics, 2005 Nov 23. PMID 16305752, Free PMC Article
    4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables K63-linked polyubiquitin modification-dependent protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of canonical NF-kappaB signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of IkappaB kinase complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    NF-kappa-B essential modulator
    Names
    I-kappa-B kinase gamma
    I-kappa-B kinase subunit gamma
    IKK-gamma
    IKKAP1
    IKKG
    NEMO
    NF-kappa-B essential modifier
    ikB kinase subunit gamma
    ikB kinase-associated protein 1
    inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
    inhibitor of nuclear factor kappa B kinase subunit gamma

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174354.3 → NP_776779.1  NF-kappa-B essential modulator

      See identical proteins and their annotated locations for NP_776779.1

      Status: PROVISIONAL

      Source sequence(s)
      BC133306
      UniProtKB/Swiss-Prot
      A2VDM3, Q5E9T0, Q5EA16, Q95KU9
      Related
      ENSBTAP00000008224.5, ENSBTAT00000008224.6
      Conserved Domains (3) summary
      pfam11577
      Location:44 → 111
      NEMO; NF-kappa-B essential modulator NEMO
      pfam16516
      Location:259 → 344
      CC2-LZ; Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
      cl00459
      Location:182 → 287
      MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037357.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      37582609..37641404
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005227728.5 → XP_005227785.1  NF-kappa-B essential modulator isoform X6

      See identical proteins and their annotated locations for XP_005227785.1

      UniProtKB/Swiss-Prot
      A2VDM3, Q5E9T0, Q5EA16, Q95KU9
      Conserved Domains (3) summary
      pfam11577
      Location:44 → 111
      NEMO; NF-kappa-B essential modulator NEMO
      pfam16516
      Location:259 → 344
      CC2-LZ; Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
      cl00459
      Location:182 → 287
      MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily

    2. XM_005227729.5 → XP_005227786.1  NF-kappa-B essential modulator isoform X6

      See identical proteins and their annotated locations for XP_005227786.1

      UniProtKB/Swiss-Prot
      A2VDM3, Q5E9T0, Q5EA16, Q95KU9
      Conserved Domains (3) summary
      pfam11577
      Location:44 → 111
      NEMO; NF-kappa-B essential modulator NEMO
      pfam16516
      Location:259 → 344
      CC2-LZ; Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
      cl00459
      Location:182 → 287
      MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily

    3. XM_015461503.3 → XP_015316989.1  NF-kappa-B essential modulator isoform X6

      UniProtKB/Swiss-Prot
      A2VDM3, Q5E9T0, Q5EA16, Q95KU9
      Conserved Domains (3) summary
      pfam11577
      Location:44 → 111
      NEMO; NF-kappa-B essential modulator NEMO
      pfam16516
      Location:259 → 344
      CC2-LZ; Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
      cl00459
      Location:182 → 287
      MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily

    4. XM_005227726.5 → XP_005227783.1  NF-kappa-B essential modulator isoform X1

      Related
      ENSBTAP00000099147.1, ENSBTAT00000099112.1
      Conserved Domains (3) summary
      pfam11577
      Location:79 → 146
      NEMO; NF-kappa-B essential modulator NEMO
      pfam16516
      Location:294 → 379
      CC2-LZ; Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
      cl00459
      Location:217 → 322
      MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily

    5. XM_010821547.4 → XP_010819849.1  NF-kappa-B essential modulator isoform X5

      Conserved Domains (3) summary
      pfam11577
      Location:79 → 146
      NEMO; NF-kappa-B essential modulator NEMO
      pfam16516
      Location:294 → 379
      CC2-LZ; Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
      cl00459
      Location:217 → 322
      MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily

    6. XM_010821545.4 → XP_010819847.1  NF-kappa-B essential modulator isoform X3

      Conserved Domains (4) summary
      COG1340
      Location:90 → 363
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      pfam11577
      Location:79 → 146
      NEMO; NF-kappa-B essential modulator NEMO
      pfam16516
      Location:287 → 372
      CC2-LZ; Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
      cl00459
      Location:217 → 315
      MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily

    7. XM_010821544.4 → XP_010819846.1  NF-kappa-B essential modulator isoform X2

      Conserved Domains (3) summary
      pfam11577
      Location:79 → 146
      NEMO; NF-kappa-B essential modulator NEMO
      pfam16516
      Location:293 → 378
      CC2-LZ; Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
      cl00459
      Location:216 → 321
      MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily

    8. XM_010821546.4 → XP_010819848.1  NF-kappa-B essential modulator isoform X4

      Conserved Domains (3) summary
      pfam11577
      Location:79 → 146
      NEMO; NF-kappa-B essential modulator NEMO
      pfam16516
      Location:286 → 371
      CC2-LZ; Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
      cl00459
      Location:216 → 314
      MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily

    9. XM_005227727.5 → XP_005227784.1  NF-kappa-B essential modulator isoform X6

      See identical proteins and their annotated locations for XP_005227784.1

      UniProtKB/Swiss-Prot
      A2VDM3, Q5E9T0, Q5EA16, Q95KU9
      Conserved Domains (3) summary
      pfam11577
      Location:44 → 111
      NEMO; NF-kappa-B essential modulator NEMO
      pfam16516
      Location:259 → 344
      CC2-LZ; Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
      cl00459
      Location:182 → 287
      MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily

    RNA

    1. XR_009493446.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95KU9.1 GenPept UniProtKB/Swiss-Prot:Q95KU9

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