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    CDH3 cadherin 3 [ Bos taurus (cattle) ]

    Gene ID: 281063, updated on 13-Apr-2024

    Summary

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    Official Symbol
    CDH3provided by VGNC
    Official Full Name
    cadherin 3provided by VGNC
    Primary source
    VGNC:VGNC:27103
    See related
    BGD:BT10164; Ensembl:ENSBTAG00000033248
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 18
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 18 NC_037345.1 (35898256..36015506)

    Chromosome 18 - NC_037345.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101907242 Neighboring gene sphingomyelin phosphodiesterase 3 Neighboring gene HIG1 domain family member 1A, mitochondrial-like Neighboring gene ZFP90 zinc finger protein Neighboring gene transfer RNA glycine (anticodon UCC) Neighboring gene transfer RNA glycine (anticodon UCC) Neighboring gene cadherin 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037345.1 Chromosome 18 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification and cloning of two species of cadherins in bovine endothelial cells. Liaw CW, et al. EMBO J, 1990 Sep. PMID 2390969, Free PMC Article
    2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables cadherin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in adherens junction organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell-cell junction assembly IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in adherens junction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of catenin complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cadherin-3
    Names
    P-cadherin
    cadherin 15, M-cadherin (myotubule)
    cadherin 3, P-cadherin (placental)
    cadherin 3, type 1, P-cadherin (placental)
    placental cadherin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001244605.1 → NP_001231534.1  cadherin-3 precursor

      Status: VALIDATED

      Source sequence(s)
      DY159370, EE961798, EV691605, X53614
      UniProtKB/TrEMBL
      E1BGT1
      Related
      ENSBTAP00000042970.4, ENSBTAT00000045591.5
      Conserved Domains (4) summary
      cd11304
      Location:219 → 324
      Cadherin_repeat; Cadherin tandem repeat domain
      pfam01049
      Location:687 → 824
      Cadherin_C; Cadherin cytoplasmic region
      cl07391
      Location:34 → 96
      Cadherin_pro; Cadherin prodomain like
      cl09101
      Location:111 → 211
      E_set; Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037345.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      35898256..36015506
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_010814403.4 → XP_010812705.1  cadherin-3 isoform X1

      Conserved Domains (4) summary
      cd11304
      Location:287 → 392
      Cadherin_repeat; Cadherin tandem repeat domain
      pfam01049
      Location:755 → 892
      Cadherin_C; Cadherin cytoplasmic region
      cl07391
      Location:102 → 164
      Cadherin_pro; Cadherin prodomain like
      cl09101
      Location:179 → 279
      E_set; Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus

    2. XM_010814404.4 → XP_010812706.1  cadherin-3 isoform X2

      Related
      ENSBTAP00000093667.1, ENSBTAT00000132052.1
      Conserved Domains (4) summary
      cd11304
      Location:269 → 374
      Cadherin_repeat; Cadherin tandem repeat domain
      pfam01049
      Location:737 → 874
      Cadherin_C; Cadherin cytoplasmic region
      cl07391
      Location:84 → 146
      Cadherin_pro; Cadherin prodomain like
      cl09101
      Location:161 → 261
      E_set; Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus

    3. XM_024977933.2 → XP_024833701.1  cadherin-3 isoform X5

      Conserved Domains (2) summary
      cd11304
      Location:21 → 126
      Cadherin_repeat; Cadherin tandem repeat domain
      pfam01049
      Location:480 → 628
      Cadherin_C; Cadherin cytoplasmic region

    4. XM_059876502.1 → XP_059732485.1  cadherin-3 isoform X5

    5. XM_010814406.4 → XP_010812708.1  cadherin-3 isoform X4

      Conserved Domains (4) summary
      cd11304
      Location:200 → 305
      Cadherin_repeat; Cadherin tandem repeat domain
      pfam01049
      Location:668 → 805
      Cadherin_C; Cadherin cytoplasmic region
      cl07391
      Location:15 → 77
      Cadherin_pro; Cadherin prodomain like
      cl09101
      Location:92 → 192
      E_set; Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus

    6. XM_010814405.4 → XP_010812707.1  cadherin-3 isoform X3

      See identical proteins and their annotated locations for XP_010812707.1

      Related
      ENSBTAP00000101566.1, ENSBTAT00000113287.1
      Conserved Domains (4) summary
      cd11304
      Location:238 → 343
      Cadherin_repeat; Cadherin tandem repeat domain
      pfam01049
      Location:706 → 843
      Cadherin_C; Cadherin cytoplasmic region
      cl07391
      Location:53 → 115
      Cadherin_pro; Cadherin prodomain like
      cl09101
      Location:130 → 230
      E_set; Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P19535.1 GenPept UniProtKB/Swiss-Prot:P19535

    Gene LinkOut

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