Ugt2b15 UDP glucuronosyltransferase family 2 member B15 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ugt2b15provided by RGD
Official Full Name: UDP glucuronosyltransferase family 2 member B15provided by RGD
Primary source: RGD:628623
See related: Ensembl:ENSRNOG00000064466 AllianceGenome:RGD:628623
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Udpgt; Rlug38; Ugt2b3; Ugt2b5; Ugt2b17; Udpgtr-3; UDPGT 2B5
Summary: Enables glucuronosyltransferase activity. Involved in several processes, including cellular response to ethanol; cellular response to hormone stimulus; and cellular response to testosterone stimulus. Predicted to be located in endoplasmic reticulum membrane. Predicted to be integral component of membrane. Predicted to be active in intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in osteoporosis. Orthologous to human UGT2B15 (UDP glucuronosyltransferase family 2 member B15) and UGT2B17 (UDP glucuronosyltransferase family 2 member B17). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 1090.9) See more
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Genomic context

Location:: 14p21

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (21122866..21138450)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (20768015..20783599)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (22375428..22486291)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables glucuronosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glucuronosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables glucuronosyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular glucuronidation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular glucuronidation	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to glucocorticoid stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to growth hormone stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to testosterone stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in estrogen metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in estrogen metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: UDP-glucuronosyltransferase 2B17

Names: 17-beta-hydroxysteroid specific; 17-beta-hydroxysteroid-specific UDPGT; UDP glucuronosyltransferase 2 family, polypeptide B15; UDP glucuronosyltransferase 2 family, polypeptide B17; UDP glucuronosyltransferase 2 family, polypeptide B5; UDP glycosyltransferase 2 family, member 3; UDP-glucuronosyltransferase 2A3-like; UDP-glucuronosyltransferase 2B17-like; UDP-glucuronosyltransferase 2B3 precursor, microsomal; UDP-glucuronosyltransferase 2B5; UDPGT 2B17; UDPGT 2B3; liver 17 beta-hydroxysteroid UDP-glucuronosyltransferase; testosterone, dihydrotestosterone, and beta-estradiol specific; testosterone, dihydrotestosterone, and beta-estradiol-specific UDPGT

NP_695226.3

EC 2.4.1.17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_153314.3 → NP_695226.3 UDP-glucuronosyltransferase 2B17 precursor

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000014

UniProtKB/Swiss-Prot

P08542, P16915

UniProtKB/TrEMBL

D3ZLR6

Related

ENSRNOP00000034723.7, ENSRNOT00000034784.7

Conserved Domains (1) summary

pfam00201
Location:24 → 527

UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase