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Scn5a sodium voltage-gated channel alpha subunit 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25665, updated on 11-Apr-2024

Summary

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Official Symbol: Scn5aprovided by RGD
Official Full Name: sodium voltage-gated channel alpha subunit 5provided by RGD
Primary source: RGD:3637
See related: Ensembl:ENSRNOG00000015049 AllianceGenome:RGD:3637
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: SCAL; Scn2x; rSkM2; Nav1.5; RSKM2X; RATRSKM2X
Summary: Enables ankyrin binding activity; fibroblast growth factor binding activity; and voltage-gated sodium channel activity involved in cardiac muscle cell action potential. Involved in several processes, including animal organ development; response to denervation involved in regulation of muscle adaptation; and sodium ion import across plasma membrane. Located in T-tubule and intercalated disc. Biomarker of brain ischemia and congestive heart failure. Human ortholog(s) of this gene implicated in heart conduction disease (multiple); intrinsic cardiomyopathy (multiple); and sudden infant death syndrome. Orthologous to human SCN5A (sodium voltage-gated channel alpha subunit 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 231.9) See more
Orthologs: human mouse all
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Genomic context

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Location:: 8q32

Exon count:: 29

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (128098613..128196515, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (119220905..119318816, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (128169191..128266681, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Melatonin treatment improves ventricular conduction via upregulation of Nav1.5 channel proteins and sodium current in the normal rat heart.
Title: Melatonin treatment improves ventricular conduction via upregulation of Nav1.5 channel proteins and sodium current in the normal rat heart.
Open-state structure and pore gating mechanism of the cardiac sodium channel.
Title: Open-state structure and pore gating mechanism of the cardiac sodium channel.
Small G-protein RhoA is a potential inhibitor of cardiac fast sodium current.
Title: Small G-protein RhoA is a potential inhibitor of cardiac fast sodium current.
Epigenetic Changes Governing Scn5a Expression in Denervated Skeletal Muscle.
Title: Epigenetic Changes Governing Scn5a Expression in Denervated Skeletal Muscle.
Structural basis for voltage-sensor trapping of the cardiac sodium channel by a deathstalker scorpion toxin.
Title: Structural basis for voltage-sensor trapping of the cardiac sodium channel by a deathstalker scorpion toxin.
Direct and Indirect Suppression of Scn5a Gene Expression Mediates Cardiac Na(+) Channel Inhibition by Wnt Signalling.
Title: Direct and Indirect Suppression of Scn5a Gene Expression Mediates Cardiac Na(+) Channel Inhibition by Wnt Signalling.
UBC9 regulates Nav1.5 expression levels in a SUMOylation-independent manner.
Title: UBC9 regulates cardiac sodium channel Na(v)1.5 ubiquitination, degradation and sodium current density.
The analysis for the protein production demonstrated Nup107-facilitated transport of Scn5a mRNA. Using RIP-PCR and luciferase assay, we found that the 5'-UTR of Scn5a mRNA was not involved in the interaction, whereas the spatial interaction between Nup107 protein and Scn5a mRNA was formed when Scn5a mRNA passing through the nuclear pore.
Title: Nucleoporin 107 facilitates the nuclear export of Scn5a mRNA to regulate cardiac bioelectricity.
The NaV1.5-Kir2.1 macromolecular complex pre-assembles early in the forward trafficking pathway. Therefore, disruption of Kir2.1 trafficking in cardiomyocytes affects trafficking of NaV1.5, which may have important implications in the mechanisms of arrhythmias in inheritable cardiac diseases.
Title: Cardiac Kir2.1 and Na(V)1.5 Channels Traffic Together to the Sarcolemma to Control Excitability.
Nav1.5 might be involved in the pathogenesis of temporal lobe epilepsy.
Title: Expression of Nav1.5 in the pathogenesis of temporal lobe epilepsy.

Submit: New GeneRIF Correction See all GeneRIFs (33)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Scn3a (e-PCR), detects polymorphism
- UniSTS:516640

BI294104 (e-PCR)
- UniSTS:246049

Scn4a (e-PCR), detects polymorphism
- UniSTS:516642

Scn5a (e-PCR), detects polymorphism
- UniSTS:516644

Scn5a (e-PCR), detects polymorphism
- UniSTS:516645

D8Wox12 (e-PCR)
- UniSTS:517787

RH94513 (e-PCR)
- UniSTS:119761

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ankyrin binding	IDA Inferred from Direct Assay more info	PubMed
enables ankyrin binding	IEA Inferred from Electronic Annotation more info
enables ankyrin binding	IPI Inferred from Physical Interaction more info	PubMed
enables ankyrin binding	ISO Inferred from Sequence Orthology more info
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables calmodulin binding	ISO Inferred from Sequence Orthology more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables fibroblast growth factor binding	IEA Inferred from Electronic Annotation more info
enables fibroblast growth factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables fibroblast growth factor binding	ISO Inferred from Sequence Orthology more info
enables nitric-oxide synthase binding	IEA Inferred from Electronic Annotation more info
enables nitric-oxide synthase binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IEA Inferred from Electronic Annotation more info
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables scaffold protein binding	IEA Inferred from Electronic Annotation more info
enables scaffold protein binding	ISO Inferred from Sequence Orthology more info
enables transmembrane transporter binding	IEA Inferred from Electronic Annotation more info
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info
enables voltage-gated sodium channel activity	ISO Inferred from Sequence Orthology more info
enables voltage-gated sodium channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables voltage-gated sodium channel activity involved in AV node cell action potential	IEA Inferred from Electronic Annotation more info
enables voltage-gated sodium channel activity involved in AV node cell action potential	ISO Inferred from Sequence Orthology more info
enables voltage-gated sodium channel activity involved in AV node cell action potential	ISS Inferred from Sequence or Structural Similarity more info
enables voltage-gated sodium channel activity involved in Purkinje myocyte action potential	IEA Inferred from Electronic Annotation more info
enables voltage-gated sodium channel activity involved in Purkinje myocyte action potential	ISO Inferred from Sequence Orthology more info
enables voltage-gated sodium channel activity involved in Purkinje myocyte action potential	ISS Inferred from Sequence or Structural Similarity more info
enables voltage-gated sodium channel activity involved in SA node cell action potential	IEA Inferred from Electronic Annotation more info
enables voltage-gated sodium channel activity involved in SA node cell action potential	ISO Inferred from Sequence Orthology more info
enables voltage-gated sodium channel activity involved in SA node cell action potential	ISS Inferred from Sequence or Structural Similarity more info
enables voltage-gated sodium channel activity involved in bundle of His cell action potential	IEA Inferred from Electronic Annotation more info
enables voltage-gated sodium channel activity involved in bundle of His cell action potential	ISO Inferred from Sequence Orthology more info
enables voltage-gated sodium channel activity involved in bundle of His cell action potential	ISS Inferred from Sequence or Structural Similarity more info
enables voltage-gated sodium channel activity involved in cardiac muscle cell action potential	IBA Inferred from Biological aspect of Ancestor more info
enables voltage-gated sodium channel activity involved in cardiac muscle cell action potential	IMP Inferred from Mutant Phenotype more info	PubMed
enables voltage-gated sodium channel activity involved in cardiac muscle cell action potential	ISO Inferred from Sequence Orthology more info
enables voltage-gated sodium channel activity involved in cardiac muscle cell action potential	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in AV node cell action potential	ISO Inferred from Sequence Orthology more info
involved_in AV node cell action potential	ISS Inferred from Sequence or Structural Similarity more info
involved_in AV node cell to bundle of His cell communication	ISO Inferred from Sequence Orthology more info
involved_in AV node cell to bundle of His cell communication	ISS Inferred from Sequence or Structural Similarity more info
involved_in SA node cell action potential	ISO Inferred from Sequence Orthology more info
involved_in SA node cell action potential	ISS Inferred from Sequence or Structural Similarity more info
involved_in atrial cardiac muscle cell action potential	ISO Inferred from Sequence Orthology more info
involved_in atrial cardiac muscle cell action potential	ISS Inferred from Sequence or Structural Similarity more info
involved_in brainstem development	IEP Inferred from Expression Pattern more info	PubMed
involved_in bundle of His cell action potential	ISO Inferred from Sequence Orthology more info
involved_in bundle of His cell action potential	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within calcium ion homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cardiac muscle cell action potential involved in contraction	ISO Inferred from Sequence Orthology more info
involved_in cardiac muscle cell action potential involved in contraction	ISO Inferred from Sequence Orthology more info
involved_in cardiac muscle cell action potential involved in contraction	ISS Inferred from Sequence or Structural Similarity more info
involved_in cardiac muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in cardiac muscle contraction	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cardiac ventricle development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell communication involved in cardiac conduction	ISO Inferred from Sequence Orthology more info
involved_in cellular response to calcium ion	IEA Inferred from Electronic Annotation more info
involved_in cellular response to calcium ion	ISO Inferred from Sequence Orthology more info
involved_in cellular response to calcium ion	ISS Inferred from Sequence or Structural Similarity more info
involved_in cerebellum development	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within establishment of localization in cell	ISO Inferred from Sequence Orthology more info
involved_in membrane depolarization	ISO Inferred from Sequence Orthology more info
involved_in membrane depolarization	ISS Inferred from Sequence or Structural Similarity more info
involved_in membrane depolarization during AV node cell action potential	IEA Inferred from Electronic Annotation more info
involved_in membrane depolarization during AV node cell action potential	ISO Inferred from Sequence Orthology more info
involved_in membrane depolarization during AV node cell action potential	ISS Inferred from Sequence or Structural Similarity more info
involved_in membrane depolarization during Purkinje myocyte cell action potential	IEA Inferred from Electronic Annotation more info
involved_in membrane depolarization during Purkinje myocyte cell action potential	ISO Inferred from Sequence Orthology more info
involved_in membrane depolarization during Purkinje myocyte cell action potential	ISS Inferred from Sequence or Structural Similarity more info
involved_in membrane depolarization during SA node cell action potential	IEA Inferred from Electronic Annotation more info
involved_in membrane depolarization during SA node cell action potential	ISO Inferred from Sequence Orthology more info
involved_in membrane depolarization during SA node cell action potential	ISS Inferred from Sequence or Structural Similarity more info
involved_in membrane depolarization during action potential	IBA Inferred from Biological aspect of Ancestor more info
involved_in membrane depolarization during action potential	ISO Inferred from Sequence Orthology more info
involved_in membrane depolarization during action potential	ISS Inferred from Sequence or Structural Similarity more info
involved_in membrane depolarization during atrial cardiac muscle cell action potential	IEA Inferred from Electronic Annotation more info
involved_in membrane depolarization during atrial cardiac muscle cell action potential	ISO Inferred from Sequence Orthology more info
involved_in membrane depolarization during bundle of His cell action potential	IEA Inferred from Electronic Annotation more info
involved_in membrane depolarization during bundle of His cell action potential	ISO Inferred from Sequence Orthology more info
involved_in membrane depolarization during bundle of His cell action potential	ISS Inferred from Sequence or Structural Similarity more info
involved_in membrane depolarization during cardiac muscle cell action potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in membrane depolarization during cardiac muscle cell action potential	ISO Inferred from Sequence Orthology more info
involved_in membrane depolarization during cardiac muscle cell action potential	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within muscle cell cellular homeostasis	ISO Inferred from Sequence Orthology more info
involved_in neuronal action potential	IBA Inferred from Biological aspect of Ancestor more info
involved_in odontogenesis of dentin-containing tooth	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of action potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of epithelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of heart rate	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of sodium ion transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of sodium ion transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of sodium ion transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of atrial cardiac muscle cell membrane depolarization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of atrial cardiac muscle cell membrane depolarization	IEA Inferred from Electronic Annotation more info
involved_in regulation of atrial cardiac muscle cell membrane depolarization	ISO Inferred from Sequence Orthology more info
involved_in regulation of atrial cardiac muscle cell membrane depolarization	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of atrial cardiac muscle cell membrane repolarization	IEA Inferred from Electronic Annotation more info
involved_in regulation of atrial cardiac muscle cell membrane repolarization	ISO Inferred from Sequence Orthology more info
involved_in regulation of atrial cardiac muscle cell membrane repolarization	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cardiac muscle cell contraction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of cardiac muscle cell contraction	ISO Inferred from Sequence Orthology more info
involved_in regulation of cardiac muscle cell contraction	ISO Inferred from Sequence Orthology more info
involved_in regulation of cardiac muscle cell contraction	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of heart rate	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of heart rate	ISO Inferred from Sequence Orthology more info
involved_in regulation of heart rate	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of heart rate by cardiac conduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of heart rate by cardiac conduction	ISO Inferred from Sequence Orthology more info
involved_in regulation of heart rate by cardiac conduction	ISO Inferred from Sequence Orthology more info
involved_in regulation of heart rate by cardiac conduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of sodium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of sodium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of sodium ion transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of ventricular cardiac muscle cell membrane depolarization	IEA Inferred from Electronic Annotation more info
involved_in regulation of ventricular cardiac muscle cell membrane depolarization	ISO Inferred from Sequence Orthology more info
involved_in regulation of ventricular cardiac muscle cell membrane depolarization	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of ventricular cardiac muscle cell membrane repolarization	IEA Inferred from Electronic Annotation more info
involved_in regulation of ventricular cardiac muscle cell membrane repolarization	ISO Inferred from Sequence Orthology more info
involved_in regulation of ventricular cardiac muscle cell membrane repolarization	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to denervation involved in regulation of muscle adaptation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to organic cyclic compound	ISO Inferred from Sequence Orthology more info
involved_in sodium ion import across plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sodium ion import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in sodium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in sodium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in sodium ion transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sodium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in sodium ion transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within sodium ion transport	ISO Inferred from Sequence Orthology more info
involved_in sodium ion transport	ISO Inferred from Sequence Orthology more info
involved_in sodium ion transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in telencephalon development	IEP Inferred from Expression Pattern more info	PubMed
involved_in ventricular cardiac muscle cell action potential	IEA Inferred from Electronic Annotation more info
involved_in ventricular cardiac muscle cell action potential	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in T-tubule	IDA Inferred from Direct Assay more info	PubMed
located_in T-tubule	IEA Inferred from Electronic Annotation more info
located_in T-tubule	ISO Inferred from Sequence Orthology more info
located_in Z disc	IEA Inferred from Electronic Annotation more info
located_in Z disc	ISO Inferred from Sequence Orthology more info
located_in Z disc	ISS Inferred from Sequence or Structural Similarity more info
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
located_in caveola	IEA Inferred from Electronic Annotation more info
located_in caveola	ISO Inferred from Sequence Orthology more info
located_in caveola	ISS Inferred from Sequence or Structural Similarity more info
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
located_in intercalated disc	IDA Inferred from Direct Assay more info	PubMed
located_in intercalated disc	IEA Inferred from Electronic Annotation more info
located_in intercalated disc	ISO Inferred from Sequence Orthology more info
located_in intercalated disc	ISS Inferred from Sequence or Structural Similarity more info
located_in lateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in sarcolemma	ISO Inferred from Sequence Orthology more info
part_of sodium channel complex	ISO Inferred from Sequence Orthology more info
part_of voltage-gated sodium channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated sodium channel complex	IEA Inferred from Electronic Annotation more info
part_of voltage-gated sodium channel complex	ISO Inferred from Sequence Orthology more info
part_of voltage-gated sodium channel complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: sodium channel protein type 5 subunit alpha

Names: skeletal muscle voltage-sensitive sodium channel subtype 2; sodium channel protein cardiac muscle subunit alpha; sodium channel protein type V subunit alpha; sodium channel, voltage-gated, type 5, alpha subunit; sodium channel, voltage-gated, type V, alpha polypeptide; sodium channel, voltage-gated, type V, alpha subunit; voltage-gated sodium channel Nav1.5c; voltage-gated sodium channel subunit alpha Nav1.5

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001160162.3 → NP_001153634.2 sodium channel protein type 5 subunit alpha isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.

Source sequence(s)

JAXUCZ010000008

UniProtKB/TrEMBL

A6I3X4, F1LNF5

Related

ENSRNOP00000060586.2, ENSRNOT00000066932.5

Conserved Domains (5) summary

cd13433
Location:1420 → 1472

Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits

pfam00520
Location:1153 → 1428

Ion_trans; Ion transport protein

pfam06512
Location:956 → 1149

Na_trans_assoc; Sodium ion transport-associated

pfam11933
Location:484 → 668

Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel

pfam16905
Location:1743 → 1790

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
NM_013125.4 → NP_037257.2 sodium channel protein type 5 subunit alpha isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

JAXUCZ010000008

UniProtKB/Swiss-Prot

P15389, Q925G6

Conserved Domains (4) summary

cd13433
Location:1473 → 1525

Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits

pfam00520
Location:1206 → 1481

Ion_trans; Ion transport protein

pfam06512
Location:956 → 1202

Na_trans_assoc; Sodium ion transport-associated

pfam11933
Location:510 → 668

Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

128098613..128196515 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039080899.2 → XP_038936827.1 sodium channel protein type 5 subunit alpha isoform X1

UniProtKB/Swiss-Prot

P15389, Q925G6

UniProtKB/TrEMBL

F1LPK3

Related

ENSRNOP00000060180.3

Conserved Domains (5) summary

cd13433
Location:1474 → 1526

Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits

pfam00520
Location:1207 → 1482

Ion_trans; Ion transport protein

pfam06512
Location:956 → 1203

Na_trans_assoc; Sodium ion transport-associated

pfam11933
Location:484 → 668

Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel

pfam16905
Location:1797 → 1844

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_039080901.2 → XP_038936829.1 sodium channel protein type 5 subunit alpha isoform X4

UniProtKB/TrEMBL

A6I3X4

Conserved Domains (5) summary

cd13433
Location:1420 → 1472

Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits

pfam00520
Location:1153 → 1428

Ion_trans; Ion transport protein

pfam06512
Location:956 → 1149

Na_trans_assoc; Sodium ion transport-associated

pfam11933
Location:484 → 668

Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel

pfam16905
Location:1743 → 1790

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_017595481.3 → XP_017450970.1 sodium channel protein type 5 subunit alpha isoform X3

UniProtKB/Swiss-Prot

P15389, Q925G6
XM_039080900.2 → XP_038936828.1 sodium channel protein type 5 subunit alpha isoform X2

UniProtKB/Swiss-Prot

P15389, Q925G6

UniProtKB/TrEMBL

A0A0G2JWG8

Related

ENSRNOP00000069875.2

Conserved Domains (5) summary

cd13433
Location:1474 → 1526

Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits

pfam00520
Location:1207 → 1482

Ion_trans; Ion transport protein

pfam06512
Location:956 → 1203

Na_trans_assoc; Sodium ion transport-associated

pfam11933
Location:484 → 668

Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel

pfam16905
Location:1797 → 1844

GPHH; Voltage-dependent L-type calcium channel, IQ-associated