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    Tank TRAF family member-associated NFKB activator [ Rattus norvegicus (Norway rat) ]

    Gene ID: 252961, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Tankprovided by RGD
    Official Full Name
    TRAF family member-associated NFKB activatorprovided by RGD
    Primary source
    RGD:628859
    See related
    Ensembl:ENSRNOG00000008859 AllianceGenome:RGD:628859
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable deubiquitinase activator activity and ubiquitin protein ligase binding activity. Predicted to contribute to thiol-dependent deubiquitinase. Predicted to be involved in several processes, including cellular response to cytokine stimulus; negative regulation of I-kappaB kinase/NF-kappaB signaling; and positive regulation of proteolysis. Predicted to be located in cytosol. Predicted to be part of protein-containing complex. Orthologous to human TANK (TRAF family member associated NFKB activator). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 170.5), Thymus (RPKM 154.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tank in Genome Data Viewer
    Location:
    3q21
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (66522834..66598864)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (46114230..46190270)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (47439007..47515706)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC120101552 Neighboring gene cation-dependent mannose-6-phosphate receptor pseudogene Neighboring gene proteasome 26S subunit, non-ATPase 14 Neighboring gene T-box brain transcription factor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Modulation of peripheral inflammation in sensory ganglia by nuclear factor (kappa)B decoy oligodeoxynucleotide: involvement of SRC kinase pathway. Igwe OJ. Neurosci Lett, 2005 Jun 10-17. PMID 15882800
    2. Association of the adaptor TANK with the I kappa B kinase (IKK) regulator NEMO connects IKK complexes with IKK epsilon and TBK1 kinases. Chariot A, et al. J Biol Chem, 2002 Oct 4. PMID 12133833
    3. I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction. Rothe M, et al. Proc Natl Acad Sci U S A, 1996 Aug 6. PMID 8710854, Free PMC Article
    4. TRAF Family Member-associated NF-κB Activator (TANK) Inhibits Genotoxic Nuclear Factor κB Activation by Facilitating Deubiquitinase USP10-dependent Deubiquitination of TRAF6 Ligase. Wang W, et al. J Biol Chem, 2015 May 22. PMID 25861989, Free PMC Article
    5. A diverse family of proteins containing tumor necrosis factor receptor-associated factor domains. Zapata JM, et al. J Biol Chem, 2001 Jun 29. PMID 11279055

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The present results indicate that the wild-type ODN decoy may act as a competitor for NF(kappa)B binding to its cognate recognition sequence as well as a modulator of c-Src activity in the DRG.
      Title: Modulation of peripheral inflammation in sensory ganglia by nuclear factor (kappa)B decoy oligodeoxynucleotide: involvement of SRC kinase pathway.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    contributes_to cysteine-type deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables deubiquitinase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables molecular function inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in canonical NF-kappaB signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to interleukin-1 ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to ionizing radiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to tumor necrosis factor ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of tumor necrosis factor-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein deubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of type I interferon production ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    TRAF family member-associated NF-kappa-B activator
    Names
    TRAF family member-associated Nf-kappa B activator
    TRAF interacting protein TANK

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164073.2 → NP_001157545.1  TRAF family member-associated NF-kappa-B activator isoform 2

      See identical proteins and their annotated locations for NP_001157545.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents use of an alternate promoter and 5' UTR, and uses an alternate in-frame splice site in the central coding region, compared to variant 1. The resulting isoform (2) lacks one internal residue, compared to isoform 1.
      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8J8YHZ3, Q8VDA2
      Related
      ENSRNOP00000092979.1, ENSRNOT00000116799.1
      Conserved Domains (1) summary
      pfam12845
      Location:133 → 184
      TBD; TBD domain

    2. NM_145788.3 → NP_665731.2  TRAF family member-associated NF-kappa-B activator isoform 1

      See identical proteins and their annotated locations for NP_665731.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A0G2K130, A6HLU4, Q8VDA2
      Related
      ENSRNOP00000071679.2, ENSRNOT00000081682.2
      Conserved Domains (1) summary
      pfam12845
      Location:132 → 184
      TBD; TBD domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      66522834..66598864
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006234273.5 → XP_006234335.1  TRAF family member-associated NF-kappa-B activator isoform X1

      See identical proteins and their annotated locations for XP_006234335.1

      UniProtKB/TrEMBL
      A0A0G2K130, A6HLU4, Q8VDA2
      Conserved Domains (1) summary
      pfam12845
      Location:132 → 184
      TBD; TBD domain

    2. XM_039104353.2 → XP_038960281.1  TRAF family member-associated NF-kappa-B activator isoform X5

      Conserved Domains (1) summary
      pfam12845
      Location:132 → 184
      TBD; TBD domain

    3. XM_039104355.2 → XP_038960283.1  TRAF family member-associated NF-kappa-B activator isoform X6

      Conserved Domains (1) summary
      pfam12845
      Location:132 → 168
      TBD; TBD domain

    4. XM_039104356.2 → XP_038960284.1  TRAF family member-associated NF-kappa-B activator isoform X7

      Conserved Domains (1) summary
      pfam12845
      Location:131 → 167
      TBD; TBD domain

    5. XM_039104358.2 → XP_038960286.1  TRAF family member-associated NF-kappa-B activator isoform X8

      UniProtKB/TrEMBL
      A6HLU5

    6. XM_006234274.4 → XP_006234336.1  TRAF family member-associated NF-kappa-B activator isoform X2

      See identical proteins and their annotated locations for XP_006234336.1

      UniProtKB/TrEMBL
      A0A8J8YHZ3, Q8VDA2
      Conserved Domains (1) summary
      pfam12845
      Location:133 → 184
      TBD; TBD domain

    7. XM_039104354.2 → XP_038960282.1  TRAF family member-associated NF-kappa-B activator isoform X9

      Conserved Domains (1) summary
      pfam12845
      Location:131 → 183
      TBD; TBD domain

    8. XM_063283148.1 → XP_063139218.1  TRAF family member-associated NF-kappa-B activator isoform X4

    9. XM_039104349.2 → XP_038960277.1  TRAF family member-associated NF-kappa-B activator isoform X3

      Conserved Domains (1) summary
      pfam12845
      Location:39 → 91
      TBD; TBD domain

    RNA

    1. XR_010064568.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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