Scnn1b sodium channel epithelial 1 subunit beta [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Scnn1bprovided by RGD
Official Full Name: sodium channel epithelial 1 subunit betaprovided by RGD
Primary source: RGD:3640
See related: Ensembl:ENSRNOG00000030981 AllianceGenome:RGD:3640
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RNENACB
Summary: Enables WW domain binding activity and ligand-gated sodium channel activity. Contributes to sodium ion transmembrane transporter activity. Involved in several processes, including response to hypoxia; sodium ion transport; and wound healing, spreading of epidermal cells. Located in apical plasma membrane and cell surface. Used to study nephrotic syndrome. Human ortholog(s) of this gene implicated in Liddle syndrome; autosomal recessive pseudohypoaldosteronism type 1; bronchiectasis 1; and pseudohypoaldosteronism. Orthologous to human SCNN1B (sodium channel epithelial 1 subunit beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 115.1), Lung (RPKM 56.7) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q36

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (185861326..185915717)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (176430063..176484451)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (191829547..191883991)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

deltabetagamma-ENaC is inhibited by CFTR but activated by cyclic AMP.
Title: δβγ-ENaC is inhibited by CFTR but stimulated by cAMP in Xenopus laevis oocytes.
Decreased expression of Scnn1b/g and activation of ENaC could be involved in attenuation of the aortic baroreceptor sensitivity in congestive heart failure.
Title: Altered ENaC is Associated With Aortic Baroreceptor Dysfunction in Chronic Heart Failure.
The discovered changes in the expression level of catechol-o-methyltransferase , mineralocorticoid receptor , and b-subunit of epithelial sodium channel confirm their involvement in increased sympathetic stimulation of the of hypertensive rats
Title: [Expression of Catechol-O-Methyltransferase (Comt), Mineralocorticoid Receptor (Mlr), and Epithelial Sodium Channel (ENaC) Genes in Kidneys of Hypertensive ISIAH Rats at Rest and during Response to Stress].
Suggest that beta-ENaC mediates cytotrophoblast migration and increasing beta-ENaC expression by HO-1 induction enhances migration.
Title: Heme oxygenase-1 promotes migration and β-epithelial Na+ channel expression in cytotrophoblasts and ischemic placentas.
Nedd4-2-mediated ubiquitination of beta-ENaC leading to endocytosis and degradation of apical Na(+) channels is a key feature of hypoxia-induced inhibition of transepithelial alveolar Na(+) transport.
Title: Hypoxia-induced inhibition of epithelial Na(+) channels in the lung. Role of Nedd4-2 and the ubiquitin-proteasome pathway.
level of ENaC-alpha expression decreased 0.50-fold and 0.55-fold at 6 and 12 h after an injection of LPS into the middle ear cavity
Title: Expression of ENaC in LPS-induced inflammation of middle ear mucosa.
ENaC-gamma and -beta play an important role as mechanosensitive ion channels initiating pressure-induced myogenic responses in rat posterior cerebral arteries.
Title: Epithelial Na+ channel proteins are mechanotransducers of myogenic constriction in rat posterior cerebral arteries.
Data indicate that functional ENaC (subunits Scnn1a, Scnn1b, and Scnn1g) may affect firing patterns of magnocellular cells (i.e., large neurons) in supraoptic nucleus and paraventricular nucleus and thus control secretion of vasopressin and oxytocin.
Title: Epithelial Na⁺ sodium channels in magnocellular cells of the rat supraoptic and paraventricular nuclei.
Persistent high expression of alphaENaC and increase in apical localization of beta and gammaENaC may contribute to greater retention of sodium in salt-resistant rats on a high-salt diet.
Title: Enhanced expression of epithelial sodium channels in the renal medulla of Dahl S rats.
Each of the beta-subunit isoforms (beta1-beta4) of sodium channel was expressed in neonatal cardiac cells.
Title: Functional protein expression of multiple sodium channel alpha- and beta-subunit isoforms in neonatal cardiomyocytes.

Submit: New GeneRIF Correction See all GeneRIFs (42)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D1Smu7 (e-PCR)
- UniSTS:517788

D1Smu8 (e-PCR)
- UniSTS:517845

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables WW domain binding	IDA Inferred from Direct Assay more info	PubMed
enables WW domain binding	IEA Inferred from Electronic Annotation more info
enables WW domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables WW domain binding	ISO Inferred from Sequence Orthology more info
enables ligand-gated sodium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables ligand-gated sodium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables ligand-gated sodium channel activity	IEA Inferred from Electronic Annotation more info
contributes_to ligand-gated sodium channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables ligand-gated sodium channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
contributes_to ligand-gated sodium channel activity	ISO Inferred from Sequence Orthology more info
enables ligand-gated sodium channel activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
contributes_to sodium channel activity	ISO Inferred from Sequence Orthology more info
contributes_to sodium ion transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in aldosterone metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within aldosterone metabolic process	ISO Inferred from Sequence Orthology more info
involved_in artery smooth muscle contraction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within artery smooth muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in cellular response to acidic pH	IEA Inferred from Electronic Annotation more info
involved_in cellular response to acidic pH	ISO Inferred from Sequence Orthology more info
involved_in cellular response to aldosterone	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to aldosterone	ISO Inferred from Sequence Orthology more info
involved_in cellular response to aldosterone	NAS Non-traceable Author Statement more info	PubMed
involved_in cellular response to vasopressin	NAS Non-traceable Author Statement more info	PubMed
involved_in epithelial fluid transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within epithelial fluid transport	ISO Inferred from Sequence Orthology more info
involved_in erythrocyte homeostasis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within erythrocyte homeostasis	ISO Inferred from Sequence Orthology more info
involved_in gene expression	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within gene expression	ISO Inferred from Sequence Orthology more info
involved_in intracellular sodium ion homeostasis	IDA Inferred from Direct Assay more info	PubMed
involved_in intracellular sodium ion homeostasis	IEA Inferred from Electronic Annotation more info
involved_in intracellular sodium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in leukocyte activation involved in inflammatory response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within leukocyte activation involved in inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in mucus secretion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mucus secretion	ISO Inferred from Sequence Orthology more info
involved_in multicellular organism growth	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within multicellular organism growth	ISO Inferred from Sequence Orthology more info
involved_in multicellular organismal-level water homeostasis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within multicellular organismal-level water homeostasis	ISO Inferred from Sequence Orthology more info
involved_in multicellular organismal-level water homeostasis	ISO Inferred from Sequence Orthology more info
involved_in multicellular organismal-level water homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in neutrophil activation involved in immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neutrophil activation involved in immune response	ISO Inferred from Sequence Orthology more info
involved_in neutrophil-mediated killing of bacterium	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neutrophil-mediated killing of bacterium	ISO Inferred from Sequence Orthology more info
involved_in potassium ion homeostasis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within potassium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in regulation of blood pressure	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of sodium ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in renal system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within renal system process	ISO Inferred from Sequence Orthology more info
involved_in response to food	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to food	ISO Inferred from Sequence Orthology more info
involved_in response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
involved_in sensory perception of salty taste	NAS Non-traceable Author Statement more info	PubMed
involved_in sensory perception of sour taste	NAS Non-traceable Author Statement more info	PubMed
involved_in sensory perception of taste	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sodium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in sodium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in sodium ion homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in sodium ion import across plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in sodium ion import across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in sodium ion import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in sodium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in sodium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in sodium ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in sodium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sodium ion transport	ISO Inferred from Sequence Orthology more info
involved_in wound healing, spreading of epidermal cells	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in external side of plasma membrane	IEA Inferred from Electronic Annotation more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in extracellular exosome	IEA Inferred from Electronic Annotation more info
located_in extracellular exosome	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	NAS Non-traceable Author Statement more info	PubMed
part_of sodium channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of sodium channel complex	IEA Inferred from Electronic Annotation more info
part_of sodium channel complex	ISO Inferred from Sequence Orthology more info
part_of sodium channel complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: amiloride-sensitive sodium channel subunit beta

Names: SCNEB; beta-ENaC; beta-NaCH; epithelial Na(+) channel subunit beta; nonvoltage-gated sodium channel 1 subunit beta; sodium channel epithelial 1 beta subunit; sodium channel, non-voltage-gated 1, beta subunit; sodium channel, nonvoltage-gated, type I, beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.