Prlr prolactin receptor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Prlrprovided by RGD
Official Full Name: prolactin receptorprovided by RGD
Primary source: RGD:3407
See related: Ensembl:ENSRNOG00000057557 AllianceGenome:RGD:3407
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RATPRLR
Summary: Enables prolactin receptor activity and protein kinase binding activity. Predicted to be involved in several processes, including activation of protein kinase activity; cytokine-mediated signaling pathway; and positive regulation of cold-induced thermogenesis. Predicted to act upstream of or within several processes, including gland development; receptor signaling pathway via JAK-STAT; and response to bacterium. Predicted to be located in cell surface. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Human ortholog(s) of this gene implicated in hyperprolactinemia. Orthologous to human PRLR (prolactin receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Adrenal (RPKM 788.9), Liver (RPKM 174.3) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q16

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (60861391..61051883)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (59134147..59324719)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (60131410..60325686)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study indicates that chronic prolactin administration before kainic acid induced damage induces hippocampal neuroprotection associated with prolactin receptor and VGLUT1 overexpression.
Title: Prolactin prevents the kainic acid-induced neuronal loss in the rat hippocampus by inducing prolactin receptor and putatively increasing the VGLUT1 overexpression.
This study demonstrated that the Cultured neurons expressed mRNA for both PRL and its receptor (PRLR), and both PRL and PRLR expression levels changed after the excitotoxic insult.
Title: Prolactin mediates neuroprotection against excitotoxicity in primary cell cultures of hippocampal neurons via its receptor.
Results showed that an active sexual life, with constant execution of sexual behavior, produces a sustained increase in serum PRL, prostate PRL receptors, and the pStat3 signaling pathway
Title: Correlation of prolactin levels and PRL-receptor expression with Stat and Mapk cell signaling in the prostate of long-term sexually active rats.
PRLR signaling is required for DNA synthesis and survival of rat insulinoma cells
Title: Knockdown of prolactin receptors in a pancreatic beta cell line: effects on DNA synthesis, apoptosis, and gene expression.
The cholestasis-induced changes in the intensity of prolactin receptor expression were opposite in kidney and liver cells.
Title: Prolactine receptor expression in kidney tissue of female rats with cholestasis: the effect of hyperprolactinemia.
The results demonstrate that the prolactin receptor system is altered in nonneural tissues as a result of the female's reproductive history.
Title: Reproductive experience alters prolactin receptor expression in mammary and hepatic tissues in female rats.
PRLR mRNA was highly expressed throughout the rostral preoptic area, particularly in periventricular regions surrounding the third ventricle, and there was a high degree of colocalization of PRLR mRNA in both Gad1/Gad2 and Kiss1 mRNA-containing cells.
Title: Identification of prolactin-sensitive GABA and kisspeptin neurons in regions of the rat hypothalamus involved in the control of fertility.
Report cross talk between prolactin and dopamine 1-like receptors in renal proximal tubular cells.
Title: Prolactin and dopamine 1-like receptor interaction in renal proximal tubular cells.
Expression of Prlr increases at night in the rat pineal gland ~10-fold.
Title: Night/day changes in pineal expression of >600 genes: central role of adrenergic/cAMP signaling.
Data support the concept that a maternal aggressive experience, while acutely altering PRL secretion, fails to affect medial preoptic area PRL-R(L) mRNA expression.
Title: Circulating prolactin, MPOA prolactin receptor expression and maternal aggression in lactating rats.

Submit: New GeneRIF Correction See all GeneRIFs (33)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D2Chm280 (e-PCR)
- UniSTS:518400

D12Uia2 (e-PCR)
- UniSTS:239477

Prlr (e-PCR), detects polymorphism
- UniSTS:144264

Prlr (e-PCR), detects polymorphism
- UniSTS:265612

D2Wox14 (e-PCR)
- UniSTS:240030

Prlr (e-PCR), detects polymorphism
- UniSTS:531375

PRLR (e-PCR)
- UniSTS:505783

Prlr (e-PCR), detects polymorphism
- UniSTS:505783

D2Mit24 (e-PCR), detects polymorphism
- UniSTS:240589

D2Arb6 (e-PCR), detects polymorphism
- UniSTS:227317

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cytokine binding	IBA Inferred from Biological aspect of Ancestor more info
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables lipid binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables peptide hormone binding	IBA Inferred from Biological aspect of Ancestor more info
enables peptide hormone binding	IEA Inferred from Electronic Annotation more info
enables peptide hormone binding	ISO Inferred from Sequence Orthology more info
enables prolactin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables prolactin receptor activity	IEA Inferred from Electronic Annotation more info
enables prolactin receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables prolactin receptor activity	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell surface receptor signaling pathway via JAK-STAT	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell surface receptor signaling pathway via JAK-STAT	ISO Inferred from Sequence Orthology more info
involved_in cellular response to granulocyte macrophage colony-stimulating factor stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to hormone stimulus	IEA Inferred from Electronic Annotation more info
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytokine-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in lactation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lactation	ISO Inferred from Sequence Orthology more info
involved_in mammary gland alveolus development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mammary gland alveolus development	ISO Inferred from Sequence Orthology more info
involved_in mammary gland epithelial cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mammary gland epithelial cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mammary gland epithelium development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of B cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cold-induced thermogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cold-induced thermogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of protein autophosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in prolactin signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in prostate gland growth	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within prostate gland growth	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell adhesion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in regulation of epithelial cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of epithelial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in response to bacterium	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to bacterium	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	TAS Traceable Author Statement more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: prolactin receptor

Names: PRL-R; lactogen receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001034111.1 → NP_001029283.1 prolactin receptor isoform a precursor

See identical proteins and their annotated locations for NP_001029283.1

Status: PROVISIONAL

Source sequence(s)

M57668

UniProtKB/Swiss-Prot

P05710, Q62832, Q63451, Q63479, Q63723, Q64274

UniProtKB/TrEMBL

A6KJU2

Related

ENSRNOP00000072948.2, ENSRNOT00000080786.2

Conserved Domains (2) summary

cd00063
Location:122 → 219

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cl21522
Location:19 → 115

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
NM_012630.2 → NP_036762.1 prolactin receptor isoform b precursor

See identical proteins and their annotated locations for NP_036762.1

Status: PROVISIONAL

Source sequence(s)

M19304

UniProtKB/TrEMBL

A0A0G2K813, Q58DZ7

Related

ENSRNOP00000073622.2, ENSRNOT00000084624.2

Conserved Domains (2) summary

cd00063
Location:122 → 219

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cl21522
Location:19 → 115

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

60861391..61051883

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039101746.2 → XP_038957674.2 prolactin receptor isoform X1
XM_063281314.1 → XP_063137384.1 prolactin receptor isoform X2

UniProtKB/TrEMBL

Q58DZ7
XM_063281310.1 → XP_063137380.1 prolactin receptor isoform X1
XM_063281311.1 → XP_063137381.1 prolactin receptor isoform X1
XM_039101753.2 → XP_038957681.1 prolactin receptor isoform X2

UniProtKB/TrEMBL

A0A0G2K813, Q58DZ7

Conserved Domains (2) summary

cd00063
Location:122 → 219

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cl21522
Location:19 → 115

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_039101749.2 → XP_038957677.2 prolactin receptor isoform X1
XM_063281309.1 → XP_063137379.1 prolactin receptor isoform X1
XM_039101752.2 → XP_038957680.1 prolactin receptor isoform X2

UniProtKB/TrEMBL

A0A0G2K813, Q58DZ7

Related

ENSRNOP00000074428.2

Conserved Domains (2) summary

cd00063
Location:122 → 219

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cl21522
Location:19 → 115

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_063281315.1 → XP_063137385.1 prolactin receptor isoform X2

UniProtKB/TrEMBL

Q58DZ7
XM_063281313.1 → XP_063137383.1 prolactin receptor isoform X1