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    Olfm2 olfactomedin 2 [ Mus musculus (house mouse) ]

    Gene ID: 244723, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Olfm2provided by MGI
    Official Full Name
    olfactomedin 2provided by MGI
    Primary source
    MGI:MGI:3045350
    See related
    Ensembl:ENSMUSG00000032172 AllianceGenome:MGI:3045350
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A030009A06Rik
    Summary
    Acts upstream of or within locomotory behavior and visual perception. Located in glutamatergic synapse and synaptic membrane. Part of AMPA glutamate receptor complex. Is extrinsic component of synaptic membrane. Is expressed in several structures, including central nervous system; eye; and orbito-sphenoid. Orthologous to human OLFM2 (olfactomedin 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in CNS E18 (RPKM 44.2), cortex adult (RPKM 37.9) and 9 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    9 A3; 9 7.6 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (20578986..20657660, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (20667690..20746333, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E458 Neighboring gene F-box and leucine-rich repeat protein 12 Neighboring gene ubiquitin-like 5 Neighboring gene peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1 Neighboring gene predicted gene, 39299 Neighboring gene predicted gene, 35860 Neighboring gene collagen, type V, alpha 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Olfactomedin 2 deficiency protects against diet-induced obesity. González-García I, et al. Metabolism, 2022 Apr. PMID 35026233, Free PMC Article
    2. Olfactomedin 2 Regulates Smooth Muscle Phenotypic Modulation and Vascular Remodeling Through Mediating Runt-Related Transcription Factor 2 Binding to Serum Response Factor. Shi N, et al. Arterioscler Thromb Vasc Biol, 2017 Mar. PMID 28062493, Free PMC Article
    3. Olfactomedin 2: expression in the eye and interaction with other olfactomedin domain-containing proteins. Sultana A, et al. Invest Ophthalmol Vis Sci, 2011 Apr. PMID 21228389, Free PMC Article
    4. Deletion of olfactomedin 2 induces changes in the AMPA receptor complex and impairs visual, olfactory, and motor functions in mice. Sultana A, et al. Exp Neurol, 2014 Nov. PMID 25218043, Free PMC Article
    5. High-resolution proteomics unravel architecture and molecular diversity of native AMPA receptor complexes. Schwenk J, et al. Neuron, 2012 May 24. PMID 22632720

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results suggest that heterodimers of Olfm1 and Olfm2 interact with AMPAR more efficiently than Olfm2 homodimers and that Olfm2 plays a role in the organization of the AMPA receptor complexes.
      Title: Deletion of olfactomedin 2 induces changes in the AMPA receptor complex and impairs visual, olfactory, and motor functions in mice.
    2. Highly conserved OLFM2 protein may play an important role in the course of retinal and eye development.
      Title: Olfactomedin 2: expression in the eye and interaction with other olfactomedin domain-containing proteins.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neurotransmitter receptor localization to postsynaptic specialization membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in neurotransmitter receptor localization to postsynaptic specialization membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of smooth muscle cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of vascular associated smooth muscle cell dedifferentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within visual perception IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of AMPA glutamate receptor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extrinsic component of postsynaptic density membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in extrinsic component of postsynaptic density membrane IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synaptic membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    noelin-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357635.1 → NP_001344564.1  noelin-2 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC164565, AC166365
      Consensus CDS
      CCDS90507.1
      UniProtKB/TrEMBL
      A0A1L1SV46
      Related
      ENSMUSP00000151018.2, ENSMUST00000217198.2
      Conserved Domains (2) summary
      pfam02191
      Location:222 → 466
      OLF; Olfactomedin-like domain
      pfam12308
      Location:49 → 144
      Noelin-1; Neurogenesis glycoprotein

    2. NM_001357639.1 → NP_001344568.1  noelin-2 isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC164565, AC166365
      Consensus CDS
      CCDS90508.1
      UniProtKB/TrEMBL
      A0A1L1SQX6
      Related
      ENSMUSP00000149231.2, ENSMUST00000215999.2
      Conserved Domains (2) summary
      pfam02191
      Location:200 → 444
      OLF; Olfactomedin-like domain
      pfam12308
      Location:27 → 122
      Noelin-1; Neurogenesis glycoprotein

    3. NM_173777.4 → NP_776138.2  noelin-2 isoform 3 precursor

      See identical proteins and their annotated locations for NP_776138.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC164565, AK037199, BE948965
      Consensus CDS
      CCDS40546.1
      UniProtKB/Swiss-Prot
      Q0VFZ0, Q0VG58, Q8BM13
      Related
      ENSMUSP00000034692.8, ENSMUST00000034692.9
      Conserved Domains (2) summary
      pfam02191
      Location:192 → 436
      OLF; Olfactomedin-like domain
      pfam12308
      Location:19 → 114
      Noelin-1; Neurogenesis glycoprotein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      20578986..20657660 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030244363.2 → XP_030100223.1  noelin-2 isoform X1

      Conserved Domains (2) summary
      pfam02191
      Location:187 → 431
      OLF; Olfactomedin-like domain
      pfam12308
      Location:14 → 109
      Noelin-1; Neurogenesis glycoprotein

    2. XM_030244364.2 → XP_030100224.1  noelin-2 isoform X1

      Conserved Domains (2) summary
      pfam02191
      Location:187 → 431
      OLF; Olfactomedin-like domain
      pfam12308
      Location:14 → 109
      Noelin-1; Neurogenesis glycoprotein

    3. XM_030244365.2 → XP_030100225.1  noelin-2 isoform X2

      Conserved Domains (2) summary
      pfam02191
      Location:120 → 364
      OLF; Olfactomedin-like domain
      pfam12308
      Location:1 → 42
      Noelin-1; Neurogenesis glycoprotein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BM13.2 GenPept UniProtKB/Swiss-Prot:Q8BM13

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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