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    Gpr75 G protein-coupled receptor 75 [ Mus musculus (house mouse) ]

    Gene ID: 237716, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Gpr75provided by MGI
    Official Full Name
    G protein-coupled receptor 75provided by MGI
    Primary source
    MGI:MGI:2441843
    See related
    Ensembl:ENSMUSG00000043999 AllianceGenome:MGI:2441843
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables C-C chemokine receptor activity. Involved in G protein-coupled receptor signaling pathway; chemokine-mediated signaling pathway; and regulation of neuron death. Predicted to be integral component of plasma membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including brain; heart; liver; metanephros; and skeletal muscle. Orthologous to human GPR75 (G protein-coupled receptor 75). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in cerebellum adult (RPKM 2.1), frontal lobe adult (RPKM 1.6) and 8 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    11 A4; 11 18.16 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (30834636..30846090)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (30884633..30896090)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_29068 Neighboring gene predicted gene 12100 Neighboring gene STARR-seq mESC enhancer starr_29070 Neighboring gene proteasome (prosome, macropain) activator subunit 4 Neighboring gene spindle and kinetochore-associated protein 2 pseudogene Neighboring gene endoplasmic reticulum lectin 1 Neighboring gene PDZ and LIM domain protein 1 pseudogene Neighboring gene ankyrin repeat and SOCS box-containing 3 Neighboring gene ChaC, cation transport regulator 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mice deficient for G-protein-coupled receptor 75 display altered presynaptic structural protein expression and disrupted fear conditioning recall. Speidell A, et al. J Neurochem, 2023 Jun. PMID 36978267,
    2. Gpr75-deficient mice are protected from high-fat diet-induced obesity. Hossain S, et al. Obesity (Silver Spring), 2023 Apr. PMID 36854900, Free PMC Article
    3. Sequencing of 640,000 exomes identifies GPR75 variants associated with protection from obesity. Akbari P, et al. Science, 2021 Jul 2. PMID 34210852, Free PMC Article
    4. The novel chemokine receptor, G-protein-coupled receptor 75, is expressed by islets and is coupled to stimulation of insulin secretion and improved glucose homeostasis. Liu B, et al. Diabetologia, 2013 Nov. PMID 23979485
    5. RANTES stimulates Ca2+ mobilization and inositol trisphosphate (IP3) formation in cells transfected with G protein-coupled receptor 75. Ignatov A, et al. Br J Pharmacol, 2006 Nov. PMID 17001303, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Gpr75 knockout mice display age-dependent cone photoreceptor cell loss.
      Title: Gpr75 knockout mice display age-dependent cone photoreceptor cell loss.
    2. Mice deficient for G-protein-coupled receptor 75 display altered presynaptic structural protein expression and disrupted fear conditioning recall.
      Title: Mice deficient for G-protein-coupled receptor 75 display altered presynaptic structural protein expression and disrupted fear conditioning recall.
    3. Gpr75-deficient mice are protected from high-fat diet-induced obesity.
      Title: Gpr75-deficient mice are protected from high-fat diet-induced obesity.
    4. Although CCL5 is implicated in the pathogenesis of diabetes through activation of CCRs, it has beneficial effects on beta cells through GPR75 activation.
      Title: The novel chemokine receptor, G-protein-coupled receptor 75, is expressed by islets and is coupled to stimulation of insulin secretion and improved glucose homeostasis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 
    • Endonuclease-mediated (7) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables C-C chemokine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables C-C chemokine receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables G protein-coupled receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in G protein-coupled receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chemokine-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IC
    Inferred by Curator
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    probable G-protein coupled receptor 75

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175490.4 → NP_780699.2  probable G-protein coupled receptor 75

      See identical proteins and their annotated locations for NP_780699.2

      Status: VALIDATED

      Source sequence(s)
      AK141614, BQ175263
      Consensus CDS
      CCDS24508.1
      UniProtKB/Swiss-Prot
      Q3URC1, Q6X632, Q8BXP3
      UniProtKB/TrEMBL
      Q059L0
      Related
      ENSMUSP00000105057.2, ENSMUST00000109430.2
      Conserved Domains (1) summary
      cd15007
      Location:44 → 387
      7tmA_GPR75; G protein-coupled receptor 75, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      30834636..30846090
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006514696.5 → XP_006514759.1  probable G-protein coupled receptor 75 isoform X1

      See identical proteins and their annotated locations for XP_006514759.1

      UniProtKB/Swiss-Prot
      Q3URC1, Q6X632, Q8BXP3
      UniProtKB/TrEMBL
      Q059L0
      Conserved Domains (1) summary
      cd15007
      Location:44 → 387
      7tmA_GPR75; G protein-coupled receptor 75, member of the class A family of seven-transmembrane G protein-coupled receptors
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6X632.1 GenPept UniProtKB/Swiss-Prot:Q6X632

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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