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    Man2b2 mannosidase 2, alpha B2 [ Mus musculus (house mouse) ]

    Gene ID: 17160, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Man2b2provided by MGI
    Official Full Name
    mannosidase 2, alpha B2provided by MGI
    Primary source
    MGI:MGI:1195262
    See related
    Ensembl:ENSMUSG00000029119 AllianceGenome:MGI:1195262
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA0935
    Summary
    Predicted to enable alpha-mannosidase activity. Predicted to be involved in mannose metabolic process. Predicted to be located in extracellular region. Predicted to be active in lysosome. Is expressed in nervous system. Orthologous to human MAN2B2 (mannosidase alpha class 2B member 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 75.3), ovary adult (RPKM 58.0) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    5 B3; 5 19.26 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (36963913..36987973, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (36806813..36830649, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene S100 calcium binding protein P pseudogene Neighboring gene Morf4 family associated protein 1 Neighboring gene STARR-positive B cell enhancer mm9_chr5:37221807-37222107 Neighboring gene predicted gene, 52812 Neighboring gene protein phosphatase 2, regulatory subunit B, gamma Neighboring gene protein phosphatase 2, regulatory subunit B, gamma, opposite strand

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Refinement of the expression pattern of a mouse homologue of the porcine 135-kDa alpha-d-mannosidase (MAN2B2). Tascou S, et al. Biochem Biophys Res Commun, 2000 Jun 16. PMID 10860856
    2. Characterization of a human core-specific lysosomal {alpha}1,6-mannosidase involved in N-glycan catabolism. Park C, et al. J Biol Chem, 2005 Nov 4. PMID 16115860, Free PMC Article
    3. Stage-specific expression of a mouse homologue of the porcine 135kDa alpha-D-mannosidase (MAN2B2) in type A spermatogonia. Hiramoto S, et al. Biochem Biophys Res Commun, 1997 Dec 18. PMID 9425289
    4. Lysosomal Proteome and Secretome Analysis Identifies Missorted Enzymes and Their Nondegraded Substrates in Mucolipidosis III Mouse Cells. Di Lorenzo G, et al. Mol Cell Proteomics, 2018 Aug. PMID 29773673, Free PMC Article
    5. LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow. Tseng HY, et al. J Cell Sci, 2018 Nov 21. PMID 30333137, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3) 
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables alpha-mannosidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-mannosidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on glycosyl bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mannan endo-1,6-alpha-mannosidase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mannose metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in oligosaccharide catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in oligosaccharide catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in lysosomal lumen ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    epididymis-specific alpha-mannosidase
    Names
    135 kD alpha-D-mannosidase
    135 kDa alpha-D-mannosidase
    mannosidase alpha class 2B member 2
    NP_001407765.1
    NP_001407766.1
    NP_032576.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001420836.1 → NP_001407765.1  epididymis-specific alpha-mannosidase isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC169036

    2. NM_001420837.1 → NP_001407766.1  epididymis-specific alpha-mannosidase isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AC169036

    3. NM_008550.3 → NP_032576.2  epididymis-specific alpha-mannosidase isoform 1 precursor

      See identical proteins and their annotated locations for NP_032576.2

      Status: VALIDATED

      Source sequence(s)
      AC169036
      Consensus CDS
      CCDS19243.1
      UniProtKB/Swiss-Prot
      O54782, Q69ZV1, Q8BH85, Q9DBK2
      UniProtKB/TrEMBL
      Q3TND6
      Related
      ENSMUSP00000031002.4, ENSMUST00000031002.10
      Conserved Domains (3) summary
      cd10811
      Location:27 → 352
      GH38N_AMII_Epman_like; N-terminal catalytic domain of mammalian core-specific lysosomal alpha 1,6-mannosidase and similar proteins; glycoside hydrolase family 38 (GH38)
      smart00872
      Location:358 → 439
      Alpha-mann_mid; Alpha mannosidase, middle domain
      pfam07748
      Location:491 → 1012
      Glyco_hydro_38C; Glycosyl hydrolases family 38 C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      36963913..36987973 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O54782.2 GenPept UniProtKB/Swiss-Prot:O54782

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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