Exoc4 exocyst complex component 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Exoc4provided by RGD
Official Full Name: exocyst complex component 4provided by RGD
Primary source: RGD:621791
See related: Ensembl:ENSRNOG00000046023 AllianceGenome:RGD:621791
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: ALR; Sec8; Sec8l1
Summary: Enables PDZ domain binding activity. Involved in several processes, including Golgi to transport vesicle transport; oligodendrocyte differentiation; and positive regulation of calcium-mediated signaling. Located in several cellular components, including dendritic shaft; growth cone; and postsynaptic density. Part of protein-containing complex. Is active in synaptic vesicle. Colocalizes with Golgi apparatus and endosome. Orthologous to human EXOC4 (exocyst complex component 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Muscle (RPKM 138.9), Thymus (RPKM 113.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q22

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (62774896..63551541)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (61807706..62584316)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (60549128..61358305)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

cytosolic PSD-95 interactor may function to regulate the ability of sec8 to bind to PSD-95
Title: Exocyst complex subunit sec8 binds to postsynaptic density protein-95 (PSD-95): a novel interaction regulated by cypin (cytosolic PSD-95 interactor).

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AU047597 (e-PCR)
- UniSTS:110351

D4Rat22 (e-PCR)
- UniSTS:118823

RH131294 (e-PCR)
- UniSTS:214577

RH143015 (e-PCR)
- UniSTS:232262

BF396724 (e-PCR)
- UniSTS:245854

WI-14795 (e-PCR)
- UniSTS:64416

RH131455 (e-PCR)
- UniSTS:214738

BE110230 (e-PCR)
- UniSTS:245210

RH136778 (e-PCR)
- UniSTS:218867

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables PDZ domain binding	IDA Inferred from Direct Assay more info	PubMed
enables PDZ domain binding	IEA Inferred from Electronic Annotation more info
enables PDZ domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables PDZ domain binding	ISO Inferred from Sequence Orthology more info
enables ionotropic glutamate receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in Golgi to plasma membrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in Golgi to plasma membrane transport	IEA Inferred from Electronic Annotation more info
involved_in Golgi to transport vesicle transport	IDA Inferred from Direct Assay more info	PubMed
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of cell polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in membrane biogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oligodendrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in paraxial mesoderm formation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within paraxial mesoderm formation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of calcium-mediated signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein targeting to membrane	IEA Inferred from Electronic Annotation more info
involved_in protein targeting to membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of protein transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vesicle docking involved in exocytosis	IEA Inferred from Electronic Annotation more info
involved_in vesicle targeting	TAS Traceable Author Statement more info	PubMed
involved_in vesicle tethering involved in exocytosis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Flemming body	IEA Inferred from Electronic Annotation more info
is_active_in Schaffer collateral - CA1 synapse	IDA Inferred from Direct Assay more info	PubMed
located_in cell leading edge	IDA Inferred from Direct Assay more info	PubMed
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dendritic shaft	IDA Inferred from Direct Assay more info	PubMed
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
part_of exocyst	IBA Inferred from Biological aspect of Ancestor more info
part_of exocyst	IEA Inferred from Electronic Annotation more info
part_of exocyst	TAS Traceable Author Statement more info	PubMed
located_in growth cone	IDA Inferred from Direct Assay more info	PubMed
is_active_in growth cone membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in growth cone membrane	IEA Inferred from Electronic Annotation more info
located_in growth cone membrane	ISO Inferred from Sequence Orthology more info
located_in microvillus	IEA Inferred from Electronic Annotation more info
located_in microvillus	ISO Inferred from Sequence Orthology more info
located_in myelin sheath abaxonal region	IEA Inferred from Electronic Annotation more info
located_in myelin sheath abaxonal region	ISO Inferred from Sequence Orthology more info
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
located_in neuron projection	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density, intracellular component	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info
located_in synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in synaptic vesicle	EXP Inferred from Experiment more info	PubMed
is_active_in synaptic vesicle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: exocyst complex component 4

Names: SEC8-like 1; augmenter of liver regeneration (ALR) pseudogene; exocyst complex component Sec8; rSec8; secretory protein SEC8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053875.1 → NP_446327.1 exocyst complex component 4

See identical proteins and their annotated locations for NP_446327.1

Status: VALIDATED

Source sequence(s)

FM107548, U32498

UniProtKB/Swiss-Prot

Q62824

UniProtKB/TrEMBL

M0RBF8

Related

ENSRNOP00000066892.3, ENSRNOT00000075621.3

Conserved Domains (1) summary

pfam04048
Location:57 → 143

Sec8_exocyst; Sec8 exocyst complex component specific domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

62774896..63551541

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039106944.2 → XP_038962872.1 exocyst complex component 4 isoform X2

UniProtKB/TrEMBL

M0R649

Related

ENSRNOP00000064888.3

Conserved Domains (1) summary

pfam04048
Location:57 → 143

Sec8_exocyst; Sec8 exocyst complex component specific domain
XM_039106942.2 → XP_038962870.1 exocyst complex component 4 isoform X1

UniProtKB/TrEMBL

M0R649

Conserved Domains (1) summary

pfam04048
Location:57 → 143

Sec8_exocyst; Sec8 exocyst complex component specific domain