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    Mtbp Mdm2, transformed 3T3 cell double minute p53 binding protein [ Mus musculus (house mouse) ]

    Gene ID: 105837, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Mtbpprovided by MGI
    Official Full Name
    Mdm2, transformed 3T3 cell double minute p53 binding proteinprovided by MGI
    Primary source
    MGI:MGI:2146005
    See related
    Ensembl:ENSMUSG00000022369 AllianceGenome:MGI:2146005
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MDM2BP
    Summary
    Acts upstream of or within negative regulation of cell population proliferation; negative regulation of mitotic nuclear division; and traversing start control point of mitotic cell cycle. Located in kinetochore. Is expressed in cerebellum; midbrain ventricular layer; olfactory cortex ventricular layer; and telencephalon ventricular layer. Orthologous to human MTBP (MDM2 binding protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E11.5 (RPKM 5.1), limb E14.5 (RPKM 4.4) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mtbp in Genome Data Viewer
    Location:
    15 D1; 15 22.05 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (55420800..55489819)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (55557404..55626423)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene collagen, type XIV, alpha 1 Neighboring gene STARR-seq mESC enhancer starr_38711 Neighboring gene STARR-seq mESC enhancer starr_38712 Neighboring gene predicted gene, 18787 Neighboring gene mitochondrial ribosomal protein L13 Neighboring gene STARR-seq mESC enhancer starr_38714 Neighboring gene STARR-seq mESC enhancer starr_38715 Neighboring gene syntrophin, basic 1 Neighboring gene STARR-seq mESC enhancer starr_38716 Neighboring gene STARR-seq mESC enhancer starr_38717 Neighboring gene STARR-positive B cell enhancer ABC_E5477 Neighboring gene STARR-seq mESC enhancer starr_38718 Neighboring gene STARR-seq mESC enhancer starr_38720 Neighboring gene predicted gene, 46516

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Haploinsufficiency of the Myc regulator Mtbp extends survival and delays tumor development in aging mice. Grieb BC, et al. Aging (Albany NY), 2016 Oct 30. PMID 27803394, Free PMC Article
    2. Mtbp haploinsufficiency in mice increases tumor metastasis. Iwakuma T, et al. Oncogene, 2008 Mar 20. PMID 17906694
    3. p53-independent activation of the hdm2-P2 promoter through multiple transcription factor response elements results in elevated hdm2 expression in estrogen receptor alpha-positive breast cancer cells. Phelps M, et al. Cancer Res, 2003 May 15. PMID 12750288
    4. A deficiency in Mdm2 binding protein inhibits Myc-induced B-cell proliferation and lymphomagenesis. Odvody J, et al. Oncogene, 2010 Jun 3. PMID 20305689, Free PMC Article
    5. MTBP plays a crucial role in mitotic progression and chromosome segregation. Agarwal N, et al. Cell Death Differ, 2011 Jul. PMID 21274008, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mtbp haploinsufficiency significantly increased longevity and maximal survival in mice. Reduced levels of Mtbp did not alter locomotor activity, litter size, or body size, but Mtbp heterozygous mice did exhibit elevated markers of metabolism, particularly in the liver. Mtbp(+/-) mice also had a significant delay in spontaneous cancer development
      Title: Haploinsufficiency of the Myc regulator Mtbp extends survival and delays tumor development in aging mice.
    2. Mtbp functioned independent of Mdm2 and was a limiting factor for the proliferative and transforming functions of Myc. Thus, Mtbp is a previously unrecognized regulator of Myc-induced tumorigenesis.
      Title: A deficiency in Mdm2 binding protein inhibits Myc-induced B-cell proliferation and lymphomagenesis.
    3. Mtbp haploinsufficiency in mice increases tumor metastasis
      Title: Mtbp haploinsufficiency in mice increases tumor metastasis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within mitotic spindle checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of mitotic nuclear division IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein localization to kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein localization to kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in traversing start control point of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within traversing start control point of mitotic cell cycle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mdm2-binding protein
    Names
    mMTBP

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001168250.1 → NP_001161722.1  mdm2-binding protein isoform 2

      See identical proteins and their annotated locations for NP_001161722.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) includes an alternate exon in the coding region, which results in a frameshift and an early stop codon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC123682, AK133855, BB615361
      Consensus CDS
      CCDS49609.1
      UniProtKB/Swiss-Prot
      Q8BJS8
      Related
      ENSMUSP00000129396.2, ENSMUST00000170046.8
      Conserved Domains (2) summary
      pfam14918
      Location:1 → 270
      MTBP_N; MDM2-binding
      pfam14919
      Location:287 → 622
      MTBP_mid; MDM2-binding

    2. NM_001416109.1 → NP_001403038.1  mdm2-binding protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC123682

    3. NM_001416110.1 → NP_001403039.1  mdm2-binding protein isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC123682

    4. NM_001416111.1 → NP_001403040.1  mdm2-binding protein isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC123682

    5. NM_001416112.1 → NP_001403041.1  mdm2-binding protein isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC123682

    6. NM_001416113.1 → NP_001403042.1  mdm2-binding protein isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC123682

    7. NM_134092.4 → NP_598853.3  mdm2-binding protein isoform 1

      See identical proteins and their annotated locations for NP_598853.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC123682
      Consensus CDS
      CCDS27478.1
      UniProtKB/Swiss-Prot
      Q80VU3, Q8BJS8, Q8BTU9, Q8BTW0, Q99K25, Q9ER61
      Related
      ENSMUSP00000022998.8, ENSMUST00000022998.14
      Conserved Domains (3) summary
      pfam14918
      Location:1 → 270
      MTBP_N; MDM2-binding
      pfam14919
      Location:287 → 626
      MTBP_mid; MDM2-binding
      pfam14920
      Location:630 → 884
      MTBP_C; MDM2-binding

    RNA

    1. NR_183253.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC123682

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      55420800..55489819
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011245394.2 → XP_011243696.1  mdm2-binding protein isoform X1

      Conserved Domains (2) summary
      pfam14918
      Location:1 → 270
      MTBP_N; MDM2-binding
      pfam14919
      Location:287 → 622
      MTBP_mid; MDM2-binding

    2. XM_017316360.3 → XP_017171849.1  mdm2-binding protein isoform X2

      Conserved Domains (2) summary
      pfam14919
      Location:1 → 296
      MTBP_mid; MDM2-binding
      pfam14920
      Location:300 → 554
      MTBP_C; MDM2-binding

    3. XM_017316361.3 → XP_017171850.1  mdm2-binding protein isoform X3

      Related
      ENSMUSP00000128615.2, ENSMUST00000169667.2
      Conserved Domains (2) summary
      pfam14919
      Location:2 → 225
      MTBP_mid; MDM2-binding
      pfam14920
      Location:229 → 483
      MTBP_C; MDM2-binding

    RNA

    1. XR_383964.2 RNA Sequence

    2. XR_875211.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BJS8.1 GenPept UniProtKB/Swiss-Prot:Q8BJS8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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