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    Tlr4 toll like receptor 4 [ Heterocephalus glaber (naked mole-rat) ]

    Gene ID: 101715916, updated on 8-Mar-2024

    Summary

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    Gene symbol
    Tlr4
    Gene description
    toll like receptor 4
    Locus tag
    GW7_19895
    See related
    Ensembl:ENSHGLG00000014838
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Heterocephalus glaber
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae; Heterocephalus
    Orthologs
    human mouse all
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    Genomic context

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    See Tlr4 in Genome Data Viewer
    Location:
    chromosome: Un
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    102 current HetGla_female_1.0 (GCF_000247695.1) Unplaced Scaffold NW_004624760.1 (17596516..17608955, complement)

    NW_004624760.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein 345-like Neighboring gene dnaJ homolog subfamily B member 6-like Neighboring gene sal-like protein 4 pseudogene Neighboring gene uncharacterized LOC110350124 Neighboring gene uncharacterized LOC110350120

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NW_004624760 Unplaced Scaffold Reference HetGla_female_1.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome sequencing reveals insights into physiology and longevity of the naked mole rat. Kim EB, et al. Nature, 2011 Oct 12. PMID 21993625, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables lipopolysaccharide binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables lipopolysaccharide immune receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in defense response to Gram-negative bacterium IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in toll-like receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    LOW QUALITY PROTEIN: toll-like receptor 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Heterocephalus glaber Annotation Release 102 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference HetGla_female_1.0 Primary Assembly

    Genomic

    1. NW_004624760.1 Reference HetGla_female_1.0 Primary Assembly

      Range
      17596516..17608955 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_004849478.3 → XP_004849535.1  LOW QUALITY PROTEIN: toll-like receptor 4

      UniProtKB/TrEMBL
      A0A0P6K6F8
      Related
      ENSHGLP00000020740.1, ENSHGLT00000020943.1
      Conserved Domains (5) summary
      smart00082
      Location:577 → 620
      LRRCT; Leucine rich repeat C-terminal domain
      smart00255
      Location:672 → 814
      TIR; Toll - interleukin 1 - resistance
      cd00116
      Location:58 → 234
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:57 → 79
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:54 → 114
      LRR_8; Leucine rich repeat
    Nucleotide Protein
    Heading Accession and Version

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