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    Adam8 ADAM metallopeptidase domain 8 [ Heterocephalus glaber (naked mole-rat) ]

    Gene ID: 101701563, updated on 8-Mar-2024

    Summary

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    Gene symbol
    Adam8
    Gene description
    ADAM metallopeptidase domain 8
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Heterocephalus glaber
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae; Heterocephalus
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: Un
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    102 current HetGla_female_1.0 (GCF_000247695.1) Unplaced Scaffold NW_004624737.1 (13459274..13474686)

    NW_004624737.1Genomic Context describing neighboring genes Neighboring gene 40S ribosomal protein S25 pseudogene Neighboring gene zinc finger protein 511 Neighboring gene tubulin gamma complex component 2 Neighboring gene sperm flagellar protein 1-like Neighboring gene uncharacterized LOC110347850

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NW_004624737 Unplaced Scaffold Reference HetGla_female_1.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables cell adhesion molecule binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of cellular extravasation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of membrane protein ectodomain proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    disintegrin and metalloproteinase domain-containing protein 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Heterocephalus glaber Annotation Release 102 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference HetGla_female_1.0 Primary Assembly

    Genomic

    1. NW_004624737.1 Reference HetGla_female_1.0 Primary Assembly

      Range
      13459274..13474686
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_004838691.2 → XP_004838748.1  disintegrin and metalloproteinase domain-containing protein 8 isoform X1

      See identical proteins and their annotated locations for XP_004838748.1

      UniProtKB/TrEMBL
      G5AVB3
      Conserved Domains (5) summary
      smart00050
      Location:416 → 490
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:493 → 613
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:201 → 397
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam01421
      Location:200 → 399
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:43 → 152
      Pep_M12B_propep; Reprolysin family propeptide

    2. XM_004838692.3 → XP_004838749.1  disintegrin and metalloproteinase domain-containing protein 8 isoform X1

      See identical proteins and their annotated locations for XP_004838749.1

      UniProtKB/TrEMBL
      G5AVB3
      Conserved Domains (5) summary
      smart00050
      Location:416 → 490
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:493 → 613
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:201 → 397
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam01421
      Location:200 → 399
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:43 → 152
      Pep_M12B_propep; Reprolysin family propeptide

    3. XM_021253211.1 → XP_021108870.1  disintegrin and metalloproteinase domain-containing protein 8 isoform X3

      UniProtKB/TrEMBL
      G5AVB3
      Conserved Domains (4) summary
      smart00050
      Location:416 → 490
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:493 → 613
      ACR; ADAM Cysteine-Rich Domain
      pfam01421
      Location:200 → 399
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:30 → 155
      Pep_M12B_propep; Reprolysin family propeptide

    4. XM_021253210.1 → XP_021108869.1  disintegrin and metalloproteinase domain-containing protein 8 isoform X2

      UniProtKB/TrEMBL
      G5AVB3
      Conserved Domains (4) summary
      smart00050
      Location:416 → 490
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:493 → 613
      ACR; ADAM Cysteine-Rich Domain
      pfam01421
      Location:200 → 399
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:30 → 155
      Pep_M12B_propep; Reprolysin family propeptide

    RNA

    1. XR_002392627.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version

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