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    ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase [ Ovis aries (sheep) ]

    Gene ID: 101121110, updated on 3-Apr-2024

    Summary

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    Gene symbol
    ABL2
    Gene description
    ABL proto-oncogene 2, non-receptor tyrosine kinase
    See related
    EnsemblRapid:ENSOARG00020021128
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Ovis aries
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Caprinae; Ovis
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 12
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2023_10 current ARS-UI_Ramb_v3.0 (GCF_016772045.2) 12 NC_056065.1 (59865232..59967030, complement)

    Chromosome 12 - NC_056065.1Genomic Context describing neighboring genes Neighboring gene FAM20B glycosaminoglycan xylosylkinase Neighboring gene torsin family 3 member A Neighboring gene sterol O-acyltransferase 1 Neighboring gene axonemal dynein light chain domain containing 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_056065.1 Chromosome 12 Reference ARS-UI_Ramb_v3.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables non-membrane spanning protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tyrosine-protein kinase ABL2
    Names
    v-abl Abelson murine leukemia viral oncogene homolog 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_016772045.2-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UI_Ramb_v3.0 Primary Assembly

    Genomic

    1. NC_056065.1 Reference ARS-UI_Ramb_v3.0 Primary Assembly

      Range
      59865232..59967030 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_027975916.3 → XP_027831717.1  tyrosine-protein kinase ABL2 isoform X6

      UniProtKB/TrEMBL
      W5Q539
      Related
      ENSOARP00020028350.1, ENSOART00020034348.2

    2. XM_027975915.3 → XP_027831716.1  tyrosine-protein kinase ABL2 isoform X2

      UniProtKB/TrEMBL
      A0A6P7EP07, W5Q539
      Related
      ENSOARP00020028222.1, ENSOART00020034191.2
      Conserved Domains (4) summary
      smart00808
      Location:1063 → 1182
      FABD; F-actin binding domain (FABD)
      cd09935
      Location:169 → 262
      SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
      cd11850
      Location:111 → 164
      SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
      cd05052
      Location:281 → 543
      PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase

    3. XM_060396639.1 → XP_060252622.1  tyrosine-protein kinase ABL2 isoform X5

    4. XM_060396638.1 → XP_060252621.1  tyrosine-protein kinase ABL2 isoform X1

    5. XM_012187627.5 → XP_012043017.1  tyrosine-protein kinase ABL2 isoform X8

      See identical proteins and their annotated locations for XP_012043017.1

      UniProtKB/TrEMBL
      W5Q539
      Related
      ENSOARP00020028424.2, ENSOART00020034436.2
      Conserved Domains (5) summary
      smart00808
      Location:924 → 1043
      FABD; F-actin binding domain (FABD)
      cd09935
      Location:133 → 226
      SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
      cd11850
      Location:75 → 128
      SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
      cd05052
      Location:245 → 507
      PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
      pfam07714
      Location:252 → 503
      Pkinase_Tyr; Protein tyrosine kinase

    6. XM_012187624.5 → XP_012043014.1  tyrosine-protein kinase ABL2 isoform X4

      See identical proteins and their annotated locations for XP_012043014.1

      UniProtKB/TrEMBL
      W5Q539
      Conserved Domains (5) summary
      smart00808
      Location:1027 → 1146
      FABD; F-actin binding domain (FABD)
      cd09935
      Location:133 → 226
      SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
      cd11850
      Location:75 → 128
      SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
      cd05052
      Location:245 → 507
      PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
      pfam07714
      Location:252 → 503
      Pkinase_Tyr; Protein tyrosine kinase

    7. XM_012187626.5 → XP_012043016.1  tyrosine-protein kinase ABL2 isoform X7

      See identical proteins and their annotated locations for XP_012043016.1

      UniProtKB/TrEMBL
      W5Q539
      Conserved Domains (5) summary
      smart00808
      Location:945 → 1064
      FABD; F-actin binding domain (FABD)
      cd09935
      Location:154 → 247
      SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
      cd11850
      Location:96 → 149
      SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
      cd05052
      Location:266 → 528
      PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
      pfam07714
      Location:273 → 524
      Pkinase_Tyr; Protein tyrosine kinase

    8. XM_004013834.6 → XP_004013883.1  tyrosine-protein kinase ABL2 isoform X3

      See identical proteins and their annotated locations for XP_004013883.1

      UniProtKB/TrEMBL
      W5Q539
      Related
      ENSOARP00020028397.1, ENSOART00020034404.2
      Conserved Domains (5) summary
      smart00808
      Location:1048 → 1167
      FABD; F-actin binding domain (FABD)
      cd09935
      Location:154 → 247
      SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
      cd11850
      Location:96 → 149
      SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
      cd05052
      Location:266 → 528
      PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
      pfam07714
      Location:273 → 524
      Pkinase_Tyr; Protein tyrosine kinase
    Nucleotide Protein Strain
    Heading Accession and Version

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