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    EP300 E1A binding protein p300 [ Ovis aries (sheep) ]

    Gene ID: 101110136, updated on 8-Mar-2024

    Summary

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    Gene symbol
    EP300
    Gene description
    E1A binding protein p300
    See related
    EnsemblRapid:ENSOARG00020024211
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Ovis aries
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Caprinae; Ovis
    Orthologs
    human mouse all
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    Genomic context

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    See EP300 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2023_10 current ARS-UI_Ramb_v3.0 (GCF_016772045.2) 3 NC_056056.1 (218106869..218172882)

    Chromosome 3 - NC_056056.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC132659503 Neighboring gene ring-box 1 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC121819233 Neighboring gene L3MBTL histone methyl-lysine binding protein 2 Neighboring gene chondroadherin like Neighboring gene Ran GTPase activating protein 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_056056.1 Chromosome 3 Reference ARS-UI_Ramb_v3.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables chromatin DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables histone acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables transcription coactivator activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of histone acetyltransferase complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of transcription regulator complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    histone acetyltransferase p300

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_016772045.2-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UI_Ramb_v3.0 Primary Assembly

    Genomic

    1. NC_056056.1 Reference ARS-UI_Ramb_v3.0 Primary Assembly

      Range
      218106869..218172882
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_004007010.5 → XP_004007059.3  histone acetyltransferase p300 isoform X1

      UniProtKB/TrEMBL
      W5Q976
      Related
      ENSOARP00020031392.2, ENSOART00020037910.2
      Conserved Domains (8) summary
      cd05495
      Location:1052 → 1159
      Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...
      smart00551
      Location:1730 → 1808
      ZnF_TAZ; TAZ zinc finger, present in p300 and CBP
      PHA03247
      Location:661 → 1078
      PHA03247; large tegument protein UL36; Provisional
      cd02337
      Location:1669 → 1709
      ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...
      cd15802
      Location:1171 → 1243
      RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases
      cd15646
      Location:1244 → 1278
      PHD_p300; PHD finger found in histone acetyltransferase p300
      pfam09606
      Location:1987 → 2406
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam02172
      Location:567 → 647
      KIX; KIX domain

    2. XM_042247785.1 → XP_042103719.1  histone acetyltransferase p300 isoform X2

      UniProtKB/TrEMBL
      W5Q976
      Conserved Domains (9) summary
      cd05495
      Location:993 → 1100
      Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...
      smart00551
      Location:1671 → 1749
      ZnF_TAZ; TAZ zinc finger, present in p300 and CBP
      PHA03247
      Location:602 → 1019
      PHA03247; large tegument protein UL36; Provisional
      cd02337
      Location:1610 → 1650
      ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...
      cd15802
      Location:1112 → 1184
      RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases
      cd15646
      Location:1185 → 1219
      PHD_p300; PHD finger found in histone acetyltransferase p300
      pfam09606
      Location:1928 → 2347
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam02172
      Location:508 → 588
      KIX; KIX domain
      pfam08430
      Location:120 → 217
      Forkhead_N; Forkhead N-terminal region
    Nucleotide Protein Strain
    Heading Accession and Version

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