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    PAPLN papilin, proteoglycan like sulfated glycoprotein [ Felis catus (domestic cat) ]

    Gene ID: 101091790, updated on 8-Mar-2024

    Summary

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    Official Symbol
    PAPLN
    Official Full Name
    papilin, proteoglycan like sulfated glycoprotein
    Primary source
    VGNC:VGNC:64034
    See related
    EnsemblRapid:ENSFCTG00005022438
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Felis catus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: B3
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    105 current F.catus_Fca126_mat1.0 (GCF_018350175.1) B3 NC_058373.1 (118267258..118304814)
    104 previous assembly Felis_catus_9.0 (GCF_000181335.3) B3 NC_018728.3 (120717071..120755799)

    Chromosome B3 - NC_058373.1Genomic Context describing neighboring genes Neighboring gene RNA binding motif protein 25 Neighboring gene presenilin 1 Neighboring gene uncharacterized LOC109500914 Neighboring gene uncharacterized LOC102902309 Neighboring gene NUMB endocytic adaptor protein Neighboring gene HEAT repeat containing 4 Neighboring gene ribosomal oxygenase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in extracellular matrix organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    papilin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Felis catus Annotation Release 105 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference F.catus_Fca126_mat1.0 Primary Assembly

    Genomic

    1. NC_058373.1 Reference F.catus_Fca126_mat1.0 Primary Assembly

      Range
      118267258..118304814
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_045060183.1 → XP_044916118.1  papilin isoform X6

      UniProtKB/TrEMBL
      A0A2I2UHQ6
      Conserved Domains (8) summary
      smart00408
      Location:1082 → 1141
      IGc2; Immunoglobulin C-2 Type
      smart00209
      Location:33 → 84
      TSP1; Thrombospondin type 1 repeats
      smart00409
      Location:1164 → 1244
      IG; Immunoglobulin
      smart00410
      Location:936 → 1014
      IG_like; Immunoglobulin like
      cd00109
      Location:773 → 825
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      pfam05986
      Location:187 → 302
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam16626
      Location:834 → 925
      Papilin_u7; Linking region between Kunitz_BPTI and I-set on papilin
      cd00096
      Location:1086 → 1090
      Ig; Ig strand B [structural motif]

    2. XM_045060185.1 → XP_044916120.1  papilin isoform X6

      UniProtKB/TrEMBL
      A0A2I2UHQ6
      Conserved Domains (8) summary
      smart00408
      Location:1082 → 1141
      IGc2; Immunoglobulin C-2 Type
      smart00209
      Location:33 → 84
      TSP1; Thrombospondin type 1 repeats
      smart00409
      Location:1164 → 1244
      IG; Immunoglobulin
      smart00410
      Location:936 → 1014
      IG_like; Immunoglobulin like
      cd00109
      Location:773 → 825
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      pfam05986
      Location:187 → 302
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam16626
      Location:834 → 925
      Papilin_u7; Linking region between Kunitz_BPTI and I-set on papilin
      cd00096
      Location:1086 → 1090
      Ig; Ig strand B [structural motif]

    3. XM_045060180.1 → XP_044916115.1  papilin isoform X1

      UniProtKB/TrEMBL
      A0A5F5XQL5
      Conserved Domains (8) summary
      smart00408
      Location:1131 → 1190
      IGc2; Immunoglobulin C-2 Type
      smart00209
      Location:82 → 133
      TSP1; Thrombospondin type 1 repeats
      smart00409
      Location:1213 → 1293
      IG; Immunoglobulin
      smart00410
      Location:985 → 1063
      IG_like; Immunoglobulin like
      cd00109
      Location:822 → 874
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      pfam05986
      Location:236 → 351
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam16626
      Location:883 → 974
      Papilin_u7; Linking region between Kunitz_BPTI and I-set on papilin
      cd00096
      Location:1135 → 1139
      Ig; Ig strand B [structural motif]

    4. XM_045060182.1 → XP_044916117.1  papilin isoform X5

      UniProtKB/TrEMBL
      A0A5F5XQL5
      Conserved Domains (8) summary
      smart00408
      Location:1131 → 1190
      IGc2; Immunoglobulin C-2 Type
      smart00209
      Location:82 → 133
      TSP1; Thrombospondin type 1 repeats
      smart00409
      Location:985 → 1063
      IG; Immunoglobulin
      smart00410
      Location:1213 → 1292
      IG_like; Immunoglobulin like
      cd00109
      Location:822 → 874
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      pfam05986
      Location:236 → 351
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam16626
      Location:883 → 974
      Papilin_u7; Linking region between Kunitz_BPTI and I-set on papilin
      cd00096
      Location:1135 → 1139
      Ig; Ig strand B [structural motif]

    5. XM_045060187.1 → XP_044916122.1  papilin isoform X8

      UniProtKB/TrEMBL
      A0A5F5XQL5
      Conserved Domains (7) summary
      smart00408
      Location:1131 → 1190
      IGc2; Immunoglobulin C-2 Type
      smart00209
      Location:82 → 133
      TSP1; Thrombospondin type 1 repeats
      smart00409
      Location:985 → 1063
      IG; Immunoglobulin
      cd00109
      Location:822 → 874
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      pfam05986
      Location:236 → 351
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam16626
      Location:883 → 974
      Papilin_u7; Linking region between Kunitz_BPTI and I-set on papilin
      cd00096
      Location:1135 → 1139
      Ig; Ig strand B [structural motif]

    6. XM_023255811.2 → XP_023111579.2  papilin isoform X2

      UniProtKB/TrEMBL
      A0A5F5XQL5
      Related
      ENSFCTP00005046788.1, ENSFCTT00005064444.1
      Conserved Domains (8) summary
      smart00408
      Location:1125 → 1184
      IGc2; Immunoglobulin C-2 Type
      smart00209
      Location:82 → 133
      TSP1; Thrombospondin type 1 repeats
      smart00409
      Location:1207 → 1287
      IG; Immunoglobulin
      smart00410
      Location:979 → 1057
      IG_like; Immunoglobulin like
      cd00109
      Location:816 → 868
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      pfam05986
      Location:236 → 351
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam16626
      Location:877 → 968
      Papilin_u7; Linking region between Kunitz_BPTI and I-set on papilin
      cd00096
      Location:1129 → 1133
      Ig; Ig strand B [structural motif]

    7. XM_045060181.1 → XP_044916116.1  papilin isoform X3

      UniProtKB/TrEMBL
      M3WFM0
      Conserved Domains (8) summary
      smart00408
      Location:1109 → 1168
      IGc2; Immunoglobulin C-2 Type
      smart00209
      Location:82 → 133
      TSP1; Thrombospondin type 1 repeats
      smart00409
      Location:1191 → 1271
      IG; Immunoglobulin
      smart00410
      Location:963 → 1041
      IG_like; Immunoglobulin like
      cd00109
      Location:800 → 852
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      pfam05986
      Location:236 → 351
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam16626
      Location:861 → 952
      Papilin_u7; Linking region between Kunitz_BPTI and I-set on papilin
      cd00096
      Location:1113 → 1117
      Ig; Ig strand B [structural motif]

    8. XM_023255812.2 → XP_023111580.2  papilin isoform X4

      UniProtKB/TrEMBL
      M3WFM0
      Related
      ENSFCTP00005047115.1, ENSFCTT00005065014.1
      Conserved Domains (8) summary
      smart00408
      Location:1103 → 1162
      IGc2; Immunoglobulin C-2 Type
      smart00209
      Location:82 → 133
      TSP1; Thrombospondin type 1 repeats
      smart00409
      Location:1185 → 1265
      IG; Immunoglobulin
      smart00410
      Location:957 → 1035
      IG_like; Immunoglobulin like
      cd00109
      Location:794 → 846
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      pfam05986
      Location:236 → 351
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam16626
      Location:855 → 946
      Papilin_u7; Linking region between Kunitz_BPTI and I-set on papilin
      cd00096
      Location:1107 → 1111
      Ig; Ig strand B [structural motif]

    9. XM_045060184.1 → XP_044916119.1  papilin isoform X6

      UniProtKB/TrEMBL
      A0A2I2UHQ6
      Conserved Domains (8) summary
      smart00408
      Location:1082 → 1141
      IGc2; Immunoglobulin C-2 Type
      smart00209
      Location:33 → 84
      TSP1; Thrombospondin type 1 repeats
      smart00409
      Location:1164 → 1244
      IG; Immunoglobulin
      smart00410
      Location:936 → 1014
      IG_like; Immunoglobulin like
      cd00109
      Location:773 → 825
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      pfam05986
      Location:187 → 302
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam16626
      Location:834 → 925
      Papilin_u7; Linking region between Kunitz_BPTI and I-set on papilin
      cd00096
      Location:1086 → 1090
      Ig; Ig strand B [structural motif]

    10. XM_045060186.1 → XP_044916121.1  papilin isoform X7

      UniProtKB/TrEMBL
      A0A2I2UHQ6
      Related
      ENSFCTP00005046637.1, ENSFCTT00005064170.1
      Conserved Domains (8) summary
      smart00408
      Location:1078 → 1137
      IGc2; Immunoglobulin C-2 Type
      smart00209
      Location:29 → 80
      TSP1; Thrombospondin type 1 repeats
      smart00409
      Location:1160 → 1240
      IG; Immunoglobulin
      smart00410
      Location:932 → 1010
      IG_like; Immunoglobulin like
      cd00109
      Location:769 → 821
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      pfam05986
      Location:183 → 298
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam16626
      Location:830 → 921
      Papilin_u7; Linking region between Kunitz_BPTI and I-set on papilin
      cd00096
      Location:1082 → 1086
      Ig; Ig strand B [structural motif]

    11. XM_045060188.1 → XP_044916123.1  papilin isoform X9

      UniProtKB/TrEMBL
      A0A2I2UHQ6
      Conserved Domains (7) summary
      smart00408
      Location:974 → 1033
      IGc2; Immunoglobulin C-2 Type
      smart00209
      Location:284 → 342
      TSP1; Thrombospondin type 1 repeats
      smart00409
      Location:1056 → 1136
      IG; Immunoglobulin
      cd00109
      Location:665 → 717
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      pfam05986
      Location:79 → 194
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam16626
      Location:726 → 817
      Papilin_u7; Linking region between Kunitz_BPTI and I-set on papilin
      cd00096
      Location:978 → 982
      Ig; Ig strand B [structural motif]

    RNA

    1. XR_006599773.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version

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