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    SPTBN2 spectrin beta, non-erythrocytic 2 [ Felis catus (domestic cat) ]

    Gene ID: 101089045, updated on 8-Mar-2024

    Summary

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    Official Symbol
    SPTBN2
    Official Full Name
    spectrin beta, non-erythrocytic 2
    Primary source
    VGNC:VGNC:65660
    See related
    EnsemblRapid:ENSFCTG00005034067
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Felis catus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: D1
    Exon count:
    44
    Annotation release Status Assembly Chr Location
    105 current F.catus_Fca126_mat1.0 (GCF_018350175.1) D1 NC_058377.1 (109434813..109487901, complement)
    104 previous assembly Felis_catus_9.0 (GCF_000181335.3) D1 NC_018732.3 (111669800..111709609, complement)

    Chromosome D1 - NC_058377.1Genomic Context describing neighboring genes Neighboring gene RNA-binding protein 4 Neighboring gene RNA binding motif protein 14 Neighboring gene RNA binding motif protein 4B Neighboring gene chromosome D1 C11orf80 homolog Neighboring gene elongation factor 1-alpha 1-like Neighboring gene Ras converting CAAX endopeptidase 1 Neighboring gene pyruvate carboxylase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables phospholipid binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables structural constituent of cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cortical actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of spectrin IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    spectrin beta chain, non-erythrocytic 2; spectrin beta, non-erythrocytic 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Felis catus Annotation Release 105 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference F.catus_Fca126_mat1.0 Primary Assembly

    Genomic

    1. NC_058377.1 Reference F.catus_Fca126_mat1.0 Primary Assembly

      Range
      109434813..109487901 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_045039583.1 → XP_044895518.1  spectrin beta chain, non-erythrocytic 2 isoform X3

      UniProtKB/TrEMBL
      M3W7N6
      Related
      ENSFCTP00005062131.1, ENSFCTT00005093644.1
      Conserved Domains (6) summary
      smart00150
      Location:2018 → 2075
      SPEC; Spectrin repeats
      cd00176
      Location:1384 → 1588
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd10571
      Location:2221 → 2324
      PH_beta_spectrin; Beta-spectrin pleckstrin homology (PH) domain
      pfam00435
      Location:429 → 522
      Spectrin; Spectrin repeat
      cd21246
      Location:43 → 159
      CH_SPTB-like_rpt1; first calponin homology (CH) domain found in the beta-I spectrin-like subfamily
      cd21321
      Location:173 → 291
      CH_SPTBN2_rpt2; second calponin homology (CH) domain found in spectrin beta chain, non-erythrocytic 2 (SPTBN2) and similar proteins

    2. XM_011287044.4 → XP_011285346.2  spectrin beta chain, non-erythrocytic 2 isoform X3

      UniProtKB/TrEMBL
      M3W7N6
      Conserved Domains (6) summary
      smart00150
      Location:2018 → 2075
      SPEC; Spectrin repeats
      cd00176
      Location:1384 → 1588
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd10571
      Location:2221 → 2324
      PH_beta_spectrin; Beta-spectrin pleckstrin homology (PH) domain
      pfam00435
      Location:429 → 522
      Spectrin; Spectrin repeat
      cd21246
      Location:43 → 159
      CH_SPTB-like_rpt1; first calponin homology (CH) domain found in the beta-I spectrin-like subfamily
      cd21321
      Location:173 → 291
      CH_SPTBN2_rpt2; second calponin homology (CH) domain found in spectrin beta chain, non-erythrocytic 2 (SPTBN2) and similar proteins

    3. XM_023240087.2 → XP_023095855.2  spectrin beta chain, non-erythrocytic 2 isoform X3

      UniProtKB/TrEMBL
      M3W7N6
      Related
      ENSFCTP00005062126.1, ENSFCTT00005093639.1
      Conserved Domains (6) summary
      smart00150
      Location:2018 → 2075
      SPEC; Spectrin repeats
      cd00176
      Location:1384 → 1588
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd10571
      Location:2221 → 2324
      PH_beta_spectrin; Beta-spectrin pleckstrin homology (PH) domain
      pfam00435
      Location:429 → 522
      Spectrin; Spectrin repeat
      cd21246
      Location:43 → 159
      CH_SPTB-like_rpt1; first calponin homology (CH) domain found in the beta-I spectrin-like subfamily
      cd21321
      Location:173 → 291
      CH_SPTBN2_rpt2; second calponin homology (CH) domain found in spectrin beta chain, non-erythrocytic 2 (SPTBN2) and similar proteins

    4. XM_019812716.3 → XP_019668275.2  spectrin beta chain, non-erythrocytic 2 isoform X1

      UniProtKB/TrEMBL
      M3W7N6
      Conserved Domains (4) summary
      smart00150
      Location:442 → 535
      SPEC; Spectrin repeats
      COG5069
      Location:64 → 454
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cd00176
      Location:1397 → 1601
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd10571
      Location:2234 → 2337
      PH_beta_spectrin; Beta-spectrin pleckstrin homology (PH) domain

    5. XM_011287043.4 → XP_011285345.2  spectrin beta chain, non-erythrocytic 2 isoform X2

      UniProtKB/TrEMBL
      A0A2I2U9P4
      Related
      ENSFCTP00005062119.1, ENSFCTT00005093631.1
      Conserved Domains (6) summary
      smart00150
      Location:2025 → 2082
      SPEC; Spectrin repeats
      cd00176
      Location:1391 → 1595
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd10571
      Location:2228 → 2331
      PH_beta_spectrin; Beta-spectrin pleckstrin homology (PH) domain
      pfam00435
      Location:436 → 529
      Spectrin; Spectrin repeat
      cd21246
      Location:52 → 166
      CH_SPTB-like_rpt1; first calponin homology (CH) domain found in the beta-I spectrin-like subfamily
      cd21321
      Location:180 → 298
      CH_SPTBN2_rpt2; second calponin homology (CH) domain found in spectrin beta chain, non-erythrocytic 2 (SPTBN2) and similar proteins
    Nucleotide Protein
    Heading Accession and Version

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