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    TOPBP1 DNA topoisomerase II binding protein 1 [ Felis catus (domestic cat) ]

    Gene ID: 101085568, updated on 8-Mar-2024

    Summary

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    Official Symbol
    TOPBP1
    Official Full Name
    DNA topoisomerase II binding protein 1
    Primary source
    VGNC:VGNC:66452
    See related
    EnsemblRapid:ENSFCTG00005014028
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Felis catus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: C2
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    105 current F.catus_Fca126_mat1.0 (GCF_018350175.1) C2 NC_058376.1 (128865326..128927023)
    104 previous assembly Felis_catus_9.0 (GCF_000181335.3) C2 NC_018731.3 (131427884..131489584)

    Chromosome C2 - NC_058376.1Genomic Context describing neighboring genes Neighboring gene serotransferrin Neighboring gene inhibitor of carbonic anhydrase Neighboring gene CDV3 homolog Neighboring gene uncharacterized LOC109491498 Neighboring gene uncharacterized LOC123380131

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Process Evidence Code Pubs
    involved_in DNA replication initiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in mitotic DNA replication checkpoint signaling IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in mitotic G2 DNA damage checkpoint signaling IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA topoisomerase 2-binding protein 1
    Names
    topoisomerase (DNA) II binding protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Felis catus Annotation Release 105 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference F.catus_Fca126_mat1.0 Primary Assembly

    Genomic

    1. NC_058376.1 Reference F.catus_Fca126_mat1.0 Primary Assembly

      Range
      128865326..128927023
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006936405.5 → XP_006936467.1  DNA topoisomerase 2-binding protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A5F5Y4G4, M3W3K2
      Related
      ENSFCTP00005028651.1, ENSFCTT00005040547.1
      Conserved Domains (2) summary
      pfam00533
      Location:105 → 176
      BRCT; BRCA1 C Terminus (BRCT) domain
      pfam12738
      Location:203 → 266
      PTCB-BRCT; twin BRCT domain

    2. XM_006936406.4 → XP_006936468.1  DNA topoisomerase 2-binding protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A5F5Y4G4
      Conserved Domains (2) summary
      pfam00533
      Location:56 → 127
      BRCT; BRCA1 C Terminus (BRCT) domain
      pfam12738
      Location:154 → 217
      PTCB-BRCT; twin BRCT domain

    3. XM_006936407.3 → XP_006936469.1  DNA topoisomerase 2-binding protein 1 isoform X3

      UniProtKB/TrEMBL
      A0A2I2USB3, A0A5F5Y4G4
      Related
      ENSFCTP00005028455.1, ENSFCTT00005040309.1
      Conserved Domains (2) summary
      pfam00533
      Location:41 → 112
      BRCT; BRCA1 C Terminus (BRCT) domain
      pfam12738
      Location:139 → 202
      PTCB-BRCT; twin BRCT domain

    4. XM_019810684.2 → XP_019666243.1  DNA topoisomerase 2-binding protein 1 isoform X4

      UniProtKB/TrEMBL
      A0A5F5Y4G4
      Related
      ENSFCTP00005028244.1, ENSFCTT00005040052.1
      Conserved Domains (3) summary
      pfam00533
      Location:269 → 345
      BRCT; BRCA1 C Terminus (BRCT) domain
      pfam12738
      Location:116 → 179
      PTCB-BRCT; twin BRCT domain
      cl00038
      Location:552 → 623
      BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
    Nucleotide Protein
    Heading Accession and Version

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