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    STAT4 signal transducer and activator of transcription 4 [ Felis catus (domestic cat) ]

    Gene ID: 101080650, updated on 11-Apr-2024

    Summary

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    Official Symbol
    STAT4
    Official Full Name
    signal transducer and activator of transcription 4
    Primary source
    VGNC:VGNC:80367
    See related
    EnsemblRapid:ENSFCTG00005023226
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Felis catus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: C1
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    105 current F.catus_Fca126_mat1.0 (GCF_018350175.1) C1 NC_058375.1 (177791197..177907230, complement)
    104 previous assembly Felis_catus_9.0 (GCF_000181335.3) C1 NC_018730.3 (180490786..180606510, complement)

    Chromosome C1 - NC_058375.1Genomic Context describing neighboring genes Neighboring gene glutaminase Neighboring gene signal transducer and activator of transcription 1 Neighboring gene uncharacterized LOC109496892 Neighboring gene myosin IB Neighboring gene uncharacterized LOC111561888

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell surface receptor signaling pathway via JAK-STAT IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cytokine-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in defense response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in response to peptide hormone IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    signal transducer and activator of transcription 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Felis catus Annotation Release 105 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference F.catus_Fca126_mat1.0 Primary Assembly

    Genomic

    1. NC_058375.1 Reference F.catus_Fca126_mat1.0 Primary Assembly

      Range
      177791197..177907230 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_023259573.2 → XP_023115341.1  signal transducer and activator of transcription 4 isoform X3

      UniProtKB/TrEMBL
      A0A337SS44
      Conserved Domains (4) summary
      cd10375
      Location:553 → 700
      SH2_STAT4; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 4proteins
      smart00964
      Location:2 → 121
      STAT_int; STAT protein, protein interaction domain
      cd16854
      Location:140 → 312
      STAT4_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 4 (STAT4)
      cd16848
      Location:316 → 473
      STAT4_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 4 (STAT4)

    2. XM_023259572.2 → XP_023115340.1  signal transducer and activator of transcription 4 isoform X2

      UniProtKB/TrEMBL
      A0A337SS44
      Conserved Domains (4) summary
      cd10375
      Location:563 → 709
      SH2_STAT4; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 4proteins
      smart00964
      Location:12 → 131
      STAT_int; STAT protein, protein interaction domain
      pfam01017
      Location:150 → 324
      STAT_alpha; STAT protein, all-alpha domain
      pfam02864
      Location:326 → 572
      STAT_bind; STAT protein, DNA binding domain

    3. XM_023259571.2 → XP_023115339.1  signal transducer and activator of transcription 4 isoform X1

      UniProtKB/TrEMBL
      A0A337SS44
      Conserved Domains (4) summary
      cd10375
      Location:563 → 710
      SH2_STAT4; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 4proteins
      smart00964
      Location:12 → 131
      STAT_int; STAT protein, protein interaction domain
      pfam01017
      Location:150 → 324
      STAT_alpha; STAT protein, all-alpha domain
      pfam02864
      Location:326 → 572
      STAT_bind; STAT protein, DNA binding domain

    4. XM_023259578.2 → XP_023115346.1  signal transducer and activator of transcription 4 isoform X5

      UniProtKB/TrEMBL
      A0A337SS44
      Related
      ENSFCTP00005048053.1, ENSFCTT00005066665.1
      Conserved Domains (4) summary
      cd10375
      Location:563 → 710
      SH2_STAT4; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 4proteins
      smart00964
      Location:12 → 131
      STAT_int; STAT protein, protein interaction domain
      pfam01017
      Location:150 → 324
      STAT_alpha; STAT protein, all-alpha domain
      pfam02864
      Location:326 → 572
      STAT_bind; STAT protein, DNA binding domain

    5. XM_023259577.2 → XP_023115345.1  signal transducer and activator of transcription 4 isoform X4

      UniProtKB/TrEMBL
      A0A337SS44, M3WNM1
      Related
      ENSFCTP00005048515.1, ENSFCTT00005067478.1
      Conserved Domains (4) summary
      cd10375
      Location:563 → 710
      SH2_STAT4; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 4proteins
      smart00964
      Location:12 → 131
      STAT_int; STAT protein, protein interaction domain
      pfam01017
      Location:150 → 324
      STAT_alpha; STAT protein, all-alpha domain
      pfam02864
      Location:326 → 572
      STAT_bind; STAT protein, DNA binding domain

    6. XM_023259574.2 → XP_023115342.1  signal transducer and activator of transcription 4 isoform X3

      UniProtKB/TrEMBL
      A0A337SS44
      Related
      ENSFCTP00005048358.1, ENSFCTT00005067212.1
      Conserved Domains (4) summary
      cd10375
      Location:553 → 700
      SH2_STAT4; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 4proteins
      smart00964
      Location:2 → 121
      STAT_int; STAT protein, protein interaction domain
      cd16854
      Location:140 → 312
      STAT4_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 4 (STAT4)
      cd16848
      Location:316 → 473
      STAT4_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 4 (STAT4)

    7. XM_023259575.2 → XP_023115343.1  signal transducer and activator of transcription 4 isoform X3

      UniProtKB/TrEMBL
      A0A337SS44
      Related
      ENSFCTP00005047926.1, ENSFCTT00005066426.1
      Conserved Domains (4) summary
      cd10375
      Location:553 → 700
      SH2_STAT4; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 4proteins
      smart00964
      Location:2 → 121
      STAT_int; STAT protein, protein interaction domain
      cd16854
      Location:140 → 312
      STAT4_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 4 (STAT4)
      cd16848
      Location:316 → 473
      STAT4_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 4 (STAT4)

    8. XM_023259576.2 → XP_023115344.1  signal transducer and activator of transcription 4 isoform X3

      UniProtKB/TrEMBL
      A0A337SS44
      Conserved Domains (4) summary
      cd10375
      Location:553 → 700
      SH2_STAT4; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 4proteins
      smart00964
      Location:2 → 121
      STAT_int; STAT protein, protein interaction domain
      cd16854
      Location:140 → 312
      STAT4_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 4 (STAT4)
      cd16848
      Location:316 → 473
      STAT4_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 4 (STAT4)
    Nucleotide Protein
    Heading Accession and Version

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